HBV infection in untreated HIV-infected adults in Maputo, Mozambique

Detalhes bibliográficos
Autor(a) principal: Chambal, Lúcia Mabalane
Data de Publicação: 2017
Outros Autores: Gudo, Eduardo Samo, Carimo, Awa, Corte Real, Rita, Mabunda, Nédio, Maueia, Cremildo, Vubil, Adolfo, Zicai, Ana Flora, Bhatt, Nilesh, Antunes, Francisco
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/40141
Resumo: © 2017 Chambal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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spelling HBV infection in untreated HIV-infected adults in Maputo, Mozambique© 2017 Chambal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.BACKGROUND: HIV/ HBV coinfected patients are at high risk of developing chronic HBV infection, liver cirrhosis and hepatocellular carcinoma. In Mozambique, where HIV prevalence is one of the highest in the world, HIV-infected patients are scarcely characterized in terms of HBV coinfection and 3TC-resistance mutations profile. METHODS: To characterize ART-naïve HIV-infected adults, with and without HBV coinfection, a cross-sectional study was conducted between May and November 2012 in two health centers from Maputo city, Mozambique. Subjects were consecutively enrolled in the study and, then, tested for hepatitis B surface antigen (HBsAg). Moreover, CD4+ T cells count, HBV DNA in plasma, HBV genotyping and 3TC-resistance mutations profile of HBV were assessed in HIV/HBV coinfected patients. RESULTS: In total, 518 patients were enrolled in the study. The median age was 33 years old and 66.8% were women. The median CD4+ T cells count was 361 cells/mm3 and 47 (9.1%) were coinfected with HBV. Out of 46 coinfected patients, 24 (55.2%) had HBV DNA ≥ 20 - < 20 000 and 12 (26.1%) had HBV-DNA ≥20 000. APRI > 2.0 was reported in 4.3% of coinfected and 1.7% of monoinfected patients (p = 0.228), while FIB-4 > 3.25 was reported in 4.4% of coinfected and 1.3% of monoinfected patients (p = 0.112). Genotype A was the most frequent, identified in 25/27 (92.6%) patients, whereas genotype E was present in 2/27 (7.4%) patients. No patient had 3TC-resistance mutations. CONCLUSIONS: This study showed that HBV coinfection was prevalent among ART-naïve HIV-infected adults in Mozambique. Overall, these data highlight the importance of screening HBV coinfection as an integrated measure of HIV routine care to improve health conditions and treatment of HIV/HBV coinfected patients.This work was funded by Ministry of Health of Mozambique and by ViiV Healthcare Portugal.PLOSRepositório da Universidade de LisboaChambal, Lúcia MabalaneGudo, Eduardo SamoCarimo, AwaCorte Real, RitaMabunda, NédioMaueia, CremildoVubil, AdolfoZicai, Ana FloraBhatt, NileshAntunes, Francisco2019-11-14T14:35:45Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/40141engPLoS ONE 12(7): e018183610.1371/journal. pone.01818361932-6203info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:39:16Zoai:repositorio.ul.pt:10451/40141Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:53:52.002009Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv HBV infection in untreated HIV-infected adults in Maputo, Mozambique
title HBV infection in untreated HIV-infected adults in Maputo, Mozambique
spellingShingle HBV infection in untreated HIV-infected adults in Maputo, Mozambique
Chambal, Lúcia Mabalane
title_short HBV infection in untreated HIV-infected adults in Maputo, Mozambique
title_full HBV infection in untreated HIV-infected adults in Maputo, Mozambique
title_fullStr HBV infection in untreated HIV-infected adults in Maputo, Mozambique
title_full_unstemmed HBV infection in untreated HIV-infected adults in Maputo, Mozambique
title_sort HBV infection in untreated HIV-infected adults in Maputo, Mozambique
author Chambal, Lúcia Mabalane
author_facet Chambal, Lúcia Mabalane
Gudo, Eduardo Samo
Carimo, Awa
Corte Real, Rita
Mabunda, Nédio
Maueia, Cremildo
Vubil, Adolfo
Zicai, Ana Flora
Bhatt, Nilesh
Antunes, Francisco
author_role author
author2 Gudo, Eduardo Samo
Carimo, Awa
Corte Real, Rita
Mabunda, Nédio
Maueia, Cremildo
Vubil, Adolfo
Zicai, Ana Flora
Bhatt, Nilesh
Antunes, Francisco
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Chambal, Lúcia Mabalane
Gudo, Eduardo Samo
Carimo, Awa
Corte Real, Rita
Mabunda, Nédio
Maueia, Cremildo
Vubil, Adolfo
Zicai, Ana Flora
Bhatt, Nilesh
Antunes, Francisco
description © 2017 Chambal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
2019-11-14T14:35:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/40141
url http://hdl.handle.net/10451/40141
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PLoS ONE 12(7): e0181836
10.1371/journal. pone.0181836
1932-6203
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv PLOS
publisher.none.fl_str_mv PLOS
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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