A 3D finite element model to predict the arcade-like collagen structure in a layered PCL scaffold for cartilage tissue engineering
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/23507 |
Resumo: | Recently, tissue engineering strategies have been increased in order to mimic as closely as possible the environment of the native tissue, improving the regeneration of its structure and function. Previous experiments of cartilage tissue engineering used scaffolds with a homogeneous structure. However, the zonal organization in constructs has been shown to develop functional tissues with better biomechanical and biochemical properties. McCullen et al. (2012) studied the scaffold with a trilaminar structure of fibres showed that the heterogeneous organization have superior features when compared with the homogeneous scaffolds. Similarly, Steele et al. 2014 demonstrate that bilayered cartilage scaffolds have zonal differences in cellular proliferation, biochemical composition and gene expression. The directional organization of collagen fibres in the scaffolds strongly influences the anisotropic mechanical behaviour of the tissue, since the collagen fibres are the major responsible for its mechanical strength. The main goal of this study is to present new results related with a new anisotropic finite element (FE) model to mimic the growth and the remodelling of collagen fibres in a zonal organized polycaprolactone (PCL) scaffold for cartilage tissue engineering. |
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spelling |
A 3D finite element model to predict the arcade-like collagen structure in a layered PCL scaffold for cartilage tissue engineeringCartilageCollagen fibresTissue engineeringAnisotropyFinite element modellingRecently, tissue engineering strategies have been increased in order to mimic as closely as possible the environment of the native tissue, improving the regeneration of its structure and function. Previous experiments of cartilage tissue engineering used scaffolds with a homogeneous structure. However, the zonal organization in constructs has been shown to develop functional tissues with better biomechanical and biochemical properties. McCullen et al. (2012) studied the scaffold with a trilaminar structure of fibres showed that the heterogeneous organization have superior features when compared with the homogeneous scaffolds. Similarly, Steele et al. 2014 demonstrate that bilayered cartilage scaffolds have zonal differences in cellular proliferation, biochemical composition and gene expression. The directional organization of collagen fibres in the scaffolds strongly influences the anisotropic mechanical behaviour of the tissue, since the collagen fibres are the major responsible for its mechanical strength. The main goal of this study is to present new results related with a new anisotropic finite element (FE) model to mimic the growth and the remodelling of collagen fibres in a zonal organized polycaprolactone (PCL) scaffold for cartilage tissue engineering.Taylor & Francis2018-06-15T10:05:39Z2017-01-01T00:00:00Z2017info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/23507eng1025-584210.1080/10255842.2017.1382854Cortez, SaraFreitas, FCompleto, AntónioAlves, Joséinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:45:35Zoai:ria.ua.pt:10773/23507Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:57:10.613988Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A 3D finite element model to predict the arcade-like collagen structure in a layered PCL scaffold for cartilage tissue engineering |
title |
A 3D finite element model to predict the arcade-like collagen structure in a layered PCL scaffold for cartilage tissue engineering |
spellingShingle |
A 3D finite element model to predict the arcade-like collagen structure in a layered PCL scaffold for cartilage tissue engineering Cortez, Sara Cartilage Collagen fibres Tissue engineering Anisotropy Finite element modelling |
title_short |
A 3D finite element model to predict the arcade-like collagen structure in a layered PCL scaffold for cartilage tissue engineering |
title_full |
A 3D finite element model to predict the arcade-like collagen structure in a layered PCL scaffold for cartilage tissue engineering |
title_fullStr |
A 3D finite element model to predict the arcade-like collagen structure in a layered PCL scaffold for cartilage tissue engineering |
title_full_unstemmed |
A 3D finite element model to predict the arcade-like collagen structure in a layered PCL scaffold for cartilage tissue engineering |
title_sort |
A 3D finite element model to predict the arcade-like collagen structure in a layered PCL scaffold for cartilage tissue engineering |
author |
Cortez, Sara |
author_facet |
Cortez, Sara Freitas, F Completo, António Alves, José |
author_role |
author |
author2 |
Freitas, F Completo, António Alves, José |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Cortez, Sara Freitas, F Completo, António Alves, José |
dc.subject.por.fl_str_mv |
Cartilage Collagen fibres Tissue engineering Anisotropy Finite element modelling |
topic |
Cartilage Collagen fibres Tissue engineering Anisotropy Finite element modelling |
description |
Recently, tissue engineering strategies have been increased in order to mimic as closely as possible the environment of the native tissue, improving the regeneration of its structure and function. Previous experiments of cartilage tissue engineering used scaffolds with a homogeneous structure. However, the zonal organization in constructs has been shown to develop functional tissues with better biomechanical and biochemical properties. McCullen et al. (2012) studied the scaffold with a trilaminar structure of fibres showed that the heterogeneous organization have superior features when compared with the homogeneous scaffolds. Similarly, Steele et al. 2014 demonstrate that bilayered cartilage scaffolds have zonal differences in cellular proliferation, biochemical composition and gene expression. The directional organization of collagen fibres in the scaffolds strongly influences the anisotropic mechanical behaviour of the tissue, since the collagen fibres are the major responsible for its mechanical strength. The main goal of this study is to present new results related with a new anisotropic finite element (FE) model to mimic the growth and the remodelling of collagen fibres in a zonal organized polycaprolactone (PCL) scaffold for cartilage tissue engineering. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-01T00:00:00Z 2017 2018-06-15T10:05:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/23507 |
url |
http://hdl.handle.net/10773/23507 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1025-5842 10.1080/10255842.2017.1382854 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Taylor & Francis |
publisher.none.fl_str_mv |
Taylor & Francis |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799137625533054976 |