Zoonotic Visceral Leishmaniasis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/145212 |
Resumo: | Funding Information: Funding: This study was supported by FCT-Foundation for Science and Technology, I.P., through research grant PTDC/CVT-CVT/28908/2017 and PTDC/CVT-CVT/0228/2020, and by national funds within the scope of Centro de Investigação Interdisciplinar em Sanidade Animal (CIISA, UIDB/00276/2020) and Global Health and Tropical Medicine (GHTM, UID/04413/2020). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. |
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Zoonotic Visceral LeishmaniasisNew Insights on Innate Immune Response by Blood Macrophages and Liver Kupffer Cells to Leishmania infantum ParasitesBlood macrophagesInnate immunityKupffer cellsLeishmania infantumZoonotic visceral leishmaniasisBiochemistry, Genetics and Molecular Biology(all)Immunology and Microbiology(all)Agricultural and Biological Sciences(all)SDG 3 - Good Health and Well-beingFunding Information: Funding: This study was supported by FCT-Foundation for Science and Technology, I.P., through research grant PTDC/CVT-CVT/28908/2017 and PTDC/CVT-CVT/0228/2020, and by national funds within the scope of Centro de Investigação Interdisciplinar em Sanidade Animal (CIISA, UIDB/00276/2020) and Global Health and Tropical Medicine (GHTM, UID/04413/2020). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.L. infantum is the aetiological agent of zoonotic visceral leishmaniasis (ZVL), a disease that affects humans and dogs. Leishmania parasites are well adapted to aggressive conditions inside the phagolysosome and can control the immune activation of macrophages (MØs). Although MØs are highly active phagocytic cells with the capacity to destroy pathogens, they additionally comprise the host cells for Leishmania infection, replication, and stable establishment in the mammal host. The present study compares, for the first time, the innate immune response to L. infantum infection of two different macrophage lineages: the blood macrophages and the liver macrophages (Kupffer cells, KC). Our findings showed that L. infantum takes advantage of the natural predisposition of blood-MØs to phagocyte pathogens. However, parasites rapidly subvert the mechanisms of MØs immune activation. On the other hand, KCs, which are primed for immune tolerance, are not extensively activated and can overcome the dormancy induced by the parasite, exhibiting a selection of immune mechanisms, such as extracellular trap formation. Altogether, KCs reveal a different pattern of response in contrast with blood-MØs when confronting L. infantum parasites. In addition, KCs response appears to be more efficient in managing parasite infection, thus contributing to the ability of the liver to naturally restrain Leishmania dissemination.Global Health and Tropical Medicine (GHTM)Instituto de Higiene e Medicina Tropical (IHMT)Vector borne diseases and pathogens (VBD)RUNRodrigues, Armanda VianaValério-Bolas, AnaAlexandre-Pires, GraçaPereira, Maria AiresNunes, TelmoLigeiro, Dárioda Fonseca, Isabel PereiraSantos-Gomes, Gabriela2022-11-03T22:13:10Z2022-012022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/145212engPURE: 46705282https://doi.org/10.3390/biology11010100info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:25:22Zoai:run.unl.pt:10362/145212Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:51:57.744267Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Zoonotic Visceral Leishmaniasis New Insights on Innate Immune Response by Blood Macrophages and Liver Kupffer Cells to Leishmania infantum Parasites |
| title |
Zoonotic Visceral Leishmaniasis |
| spellingShingle |
Zoonotic Visceral Leishmaniasis Rodrigues, Armanda Viana Blood macrophages Innate immunity Kupffer cells Leishmania infantum Zoonotic visceral leishmaniasis Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) Agricultural and Biological Sciences(all) SDG 3 - Good Health and Well-being |
| title_short |
Zoonotic Visceral Leishmaniasis |
| title_full |
Zoonotic Visceral Leishmaniasis |
| title_fullStr |
Zoonotic Visceral Leishmaniasis |
| title_full_unstemmed |
Zoonotic Visceral Leishmaniasis |
| title_sort |
Zoonotic Visceral Leishmaniasis |
| author |
Rodrigues, Armanda Viana |
| author_facet |
Rodrigues, Armanda Viana Valério-Bolas, Ana Alexandre-Pires, Graça Pereira, Maria Aires Nunes, Telmo Ligeiro, Dário da Fonseca, Isabel Pereira Santos-Gomes, Gabriela |
| author_role |
author |
| author2 |
Valério-Bolas, Ana Alexandre-Pires, Graça Pereira, Maria Aires Nunes, Telmo Ligeiro, Dário da Fonseca, Isabel Pereira Santos-Gomes, Gabriela |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Global Health and Tropical Medicine (GHTM) Instituto de Higiene e Medicina Tropical (IHMT) Vector borne diseases and pathogens (VBD) RUN |
| dc.contributor.author.fl_str_mv |
Rodrigues, Armanda Viana Valério-Bolas, Ana Alexandre-Pires, Graça Pereira, Maria Aires Nunes, Telmo Ligeiro, Dário da Fonseca, Isabel Pereira Santos-Gomes, Gabriela |
| dc.subject.por.fl_str_mv |
Blood macrophages Innate immunity Kupffer cells Leishmania infantum Zoonotic visceral leishmaniasis Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) Agricultural and Biological Sciences(all) SDG 3 - Good Health and Well-being |
| topic |
Blood macrophages Innate immunity Kupffer cells Leishmania infantum Zoonotic visceral leishmaniasis Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) Agricultural and Biological Sciences(all) SDG 3 - Good Health and Well-being |
| description |
Funding Information: Funding: This study was supported by FCT-Foundation for Science and Technology, I.P., through research grant PTDC/CVT-CVT/28908/2017 and PTDC/CVT-CVT/0228/2020, and by national funds within the scope of Centro de Investigação Interdisciplinar em Sanidade Animal (CIISA, UIDB/00276/2020) and Global Health and Tropical Medicine (GHTM, UID/04413/2020). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-11-03T22:13:10Z 2022-01 2022-01-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/145212 |
| url |
http://hdl.handle.net/10362/145212 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
PURE: 46705282 https://doi.org/10.3390/biology11010100 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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