Zoonotic visceral leishmaniasis : new insights on innate immune response by blood macrophages and liver kupffer cells to leishmania infantum parasites
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.5/24309 |
Resumo: | Research Areas: Life Sciences & Biomedicine |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Zoonotic visceral leishmaniasis : new insights on innate immune response by blood macrophages and liver kupffer cells to leishmania infantum parasitesBlood macrophagesKupffer cellsInnate immunityLeishmania infantumZoonotic visceral leishmaniasisResearch Areas: Life Sciences & BiomedicineL. infantum is the aetiological agent of zoonotic visceral leishmaniasis (ZVL), a disease that affects humans and dogs. Leishmania parasites are well adapted to aggressive conditions inside the phagolysosome and can control the immune activation of macrophages (MØs). Although MØs are highly active phagocytic cells with the capacity to destroy pathogens, they additionally comprise the host cells for Leishmania infection, replication, and stable establishment in the mammal host. The present study compares, for the first time, the innate immune response to L. infantum infection of two different macrophage lineages: the blood macrophages and the liver macrophages (Kupffer cells, KC). Our findings showed that L. infantum takes advantage of the natural predisposition of blood-MØs to phagocyte pathogens. However, parasites rapidly subvert the mechanisms of MØs immune activation. On the other hand, KCs, which are primed for immune tolerance, are not extensively activated and can overcome the dormancy induced by the parasite, exhibiting a selection of immune mechanisms, such as extracellular trap formation. Altogether, KCs reveal a different pattern of response in contrast with blood-MØs when confronting L. infantum parasites. In addition, KCs response appears to be more efficient in managing parasite infection, thus contributing to the ability of the liver to naturally restrain Leishmania disseminationMDPIRepositório da Universidade de LisboaRodrigues, Armanda VianaValerio-Bolas, AnaAlexandre-Pires, GraçaAires Pereira, MariaNunes, TelmoLigeiro, DarioPereira da Fonseca, IsabelSantos-Gomes, Gabriela2022-05-14T22:34:33Z2022-01-092022-01-09T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/24309engRodrigues AV, Valério-Bolas A, Alexandre-Pires G, Aires Pereira M, Nunes T, Ligeiro D, Pereira da Fonseca I, Santos-Gomes G. 2022. Zoonotic visceral leishmaniasis : new insights on innate immune response by blood macrophages and liver kupffer cells to leishmania infantum parasites. Biology, 11(1):100. DOI 10.3390/biology1101010010.3390/biology110101002079-7737info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T18:36:16Zoai:repositorio.ul.pt:10400.5/24309Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T18:36:16Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Zoonotic visceral leishmaniasis : new insights on innate immune response by blood macrophages and liver kupffer cells to leishmania infantum parasites |
title |
Zoonotic visceral leishmaniasis : new insights on innate immune response by blood macrophages and liver kupffer cells to leishmania infantum parasites |
spellingShingle |
Zoonotic visceral leishmaniasis : new insights on innate immune response by blood macrophages and liver kupffer cells to leishmania infantum parasites Rodrigues, Armanda Viana Blood macrophages Kupffer cells Innate immunity Leishmania infantum Zoonotic visceral leishmaniasis |
title_short |
Zoonotic visceral leishmaniasis : new insights on innate immune response by blood macrophages and liver kupffer cells to leishmania infantum parasites |
title_full |
Zoonotic visceral leishmaniasis : new insights on innate immune response by blood macrophages and liver kupffer cells to leishmania infantum parasites |
title_fullStr |
Zoonotic visceral leishmaniasis : new insights on innate immune response by blood macrophages and liver kupffer cells to leishmania infantum parasites |
title_full_unstemmed |
Zoonotic visceral leishmaniasis : new insights on innate immune response by blood macrophages and liver kupffer cells to leishmania infantum parasites |
title_sort |
Zoonotic visceral leishmaniasis : new insights on innate immune response by blood macrophages and liver kupffer cells to leishmania infantum parasites |
author |
Rodrigues, Armanda Viana |
author_facet |
Rodrigues, Armanda Viana Valerio-Bolas, Ana Alexandre-Pires, Graça Aires Pereira, Maria Nunes, Telmo Ligeiro, Dario Pereira da Fonseca, Isabel Santos-Gomes, Gabriela |
author_role |
author |
author2 |
Valerio-Bolas, Ana Alexandre-Pires, Graça Aires Pereira, Maria Nunes, Telmo Ligeiro, Dario Pereira da Fonseca, Isabel Santos-Gomes, Gabriela |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Rodrigues, Armanda Viana Valerio-Bolas, Ana Alexandre-Pires, Graça Aires Pereira, Maria Nunes, Telmo Ligeiro, Dario Pereira da Fonseca, Isabel Santos-Gomes, Gabriela |
dc.subject.por.fl_str_mv |
Blood macrophages Kupffer cells Innate immunity Leishmania infantum Zoonotic visceral leishmaniasis |
topic |
Blood macrophages Kupffer cells Innate immunity Leishmania infantum Zoonotic visceral leishmaniasis |
description |
Research Areas: Life Sciences & Biomedicine |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-14T22:34:33Z 2022-01-09 2022-01-09T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.5/24309 |
url |
http://hdl.handle.net/10400.5/24309 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Rodrigues AV, Valério-Bolas A, Alexandre-Pires G, Aires Pereira M, Nunes T, Ligeiro D, Pereira da Fonseca I, Santos-Gomes G. 2022. Zoonotic visceral leishmaniasis : new insights on innate immune response by blood macrophages and liver kupffer cells to leishmania infantum parasites. Biology, 11(1):100. DOI 10.3390/biology11010100 10.3390/biology11010100 2079-7737 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817549321405464576 |