Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and Its Implications for Precision Medicine
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/134771 |
Resumo: | Funding Information: This research was supported by Fundação para a Ciência e Tecnologia (PTDC/MED-TOX/30418/2017) and iNOVA4Health (UID/Multi/04462/2013). M.J.C., D.G.F.F. and J.M. were supported by FCT (PhD grant SFRH/BD/131331/2017, PhD grant PD/BD/135484/2018 and postdoctoral contract PTDC/MED-TOX/30418/2017, respectively). |
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Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and Its Implications for Precision MedicineBioenergeticsCysteine transportersCysteine-related thiolomeFerroptosisGlutathioneH SHypertensionHypoxiaKidney metabolismLysosomesAnalytical ChemistryChemistry (miscellaneous)Molecular MedicinePharmaceutical ScienceDrug DiscoveryPhysical and Theoretical ChemistryOrganic ChemistryFunding Information: This research was supported by Fundação para a Ciência e Tecnologia (PTDC/MED-TOX/30418/2017) and iNOVA4Health (UID/Multi/04462/2013). M.J.C., D.G.F.F. and J.M. were supported by FCT (PhD grant SFRH/BD/131331/2017, PhD grant PD/BD/135484/2018 and postdoctoral contract PTDC/MED-TOX/30418/2017, respectively).In this review encouraged by original data, we first provided in vivo evidence that the kidney, comparative to the liver or brain, is an organ particularly rich in cysteine. In the kidney, the total availability of cysteine was higher in cortex tissue than in the medulla and distributed in free reduced, free oxidized and protein-bound fractions (in descending order). Next, we provided a comprehensive integrated review on the evidence that supports the reliance on cysteine of the kidney beyond cysteine antioxidant properties, highlighting the relevance of cysteine and its renal metabolism in the control of cysteine excess in the body as a pivotal source of metabolites to kidney biomass and bioenergetics and a promoter of adaptive responses to stressors. This view might translate into novel perspectives on the mechanisms of kidney function and blood pressure regulation and on clinical implications of the cysteine-related thiolome as a tool in precision medicine.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)Centre for Toxicogenomics and Human Health (ToxOmics)Instituto de Tecnologia Química e Biológica António Xavier (ITQB)RUNCorreia, Maria JoãoPimpão, António B.Fernandes, Dalila G.F.Morello, JuditSequeira, Catarina O.Calado, JoaquimAntunes, Alexandra M.M.Almeida, Manuel S.Branco, PatríciaMonteiro, Emília C.Vicente, João B.Serpa, JacintaPereira, Sofia A.2022-03-17T23:23:29Z2022-02-012022-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/134771eng1420-3049PURE: 42426585https://doi.org/10.3390/molecules27041416info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:13:14Zoai:run.unl.pt:10362/134771Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:48:14.038941Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and Its Implications for Precision Medicine |
| title |
Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and Its Implications for Precision Medicine |
| spellingShingle |
Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and Its Implications for Precision Medicine Correia, Maria João Bioenergetics Cysteine transporters Cysteine-related thiolome Ferroptosis Glutathione H S Hypertension Hypoxia Kidney metabolism Lysosomes Analytical Chemistry Chemistry (miscellaneous) Molecular Medicine Pharmaceutical Science Drug Discovery Physical and Theoretical Chemistry Organic Chemistry |
| title_short |
Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and Its Implications for Precision Medicine |
| title_full |
Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and Its Implications for Precision Medicine |
| title_fullStr |
Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and Its Implications for Precision Medicine |
| title_full_unstemmed |
Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and Its Implications for Precision Medicine |
| title_sort |
Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and Its Implications for Precision Medicine |
| author |
Correia, Maria João |
| author_facet |
Correia, Maria João Pimpão, António B. Fernandes, Dalila G.F. Morello, Judit Sequeira, Catarina O. Calado, Joaquim Antunes, Alexandra M.M. Almeida, Manuel S. Branco, Patrícia Monteiro, Emília C. Vicente, João B. Serpa, Jacinta Pereira, Sofia A. |
| author_role |
author |
| author2 |
Pimpão, António B. Fernandes, Dalila G.F. Morello, Judit Sequeira, Catarina O. Calado, Joaquim Antunes, Alexandra M.M. Almeida, Manuel S. Branco, Patrícia Monteiro, Emília C. Vicente, João B. Serpa, Jacinta Pereira, Sofia A. |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Centro de Estudos de Doenças Crónicas (CEDOC) Centre for Toxicogenomics and Human Health (ToxOmics) Instituto de Tecnologia Química e Biológica António Xavier (ITQB) RUN |
| dc.contributor.author.fl_str_mv |
Correia, Maria João Pimpão, António B. Fernandes, Dalila G.F. Morello, Judit Sequeira, Catarina O. Calado, Joaquim Antunes, Alexandra M.M. Almeida, Manuel S. Branco, Patrícia Monteiro, Emília C. Vicente, João B. Serpa, Jacinta Pereira, Sofia A. |
| dc.subject.por.fl_str_mv |
Bioenergetics Cysteine transporters Cysteine-related thiolome Ferroptosis Glutathione H S Hypertension Hypoxia Kidney metabolism Lysosomes Analytical Chemistry Chemistry (miscellaneous) Molecular Medicine Pharmaceutical Science Drug Discovery Physical and Theoretical Chemistry Organic Chemistry |
| topic |
Bioenergetics Cysteine transporters Cysteine-related thiolome Ferroptosis Glutathione H S Hypertension Hypoxia Kidney metabolism Lysosomes Analytical Chemistry Chemistry (miscellaneous) Molecular Medicine Pharmaceutical Science Drug Discovery Physical and Theoretical Chemistry Organic Chemistry |
| description |
Funding Information: This research was supported by Fundação para a Ciência e Tecnologia (PTDC/MED-TOX/30418/2017) and iNOVA4Health (UID/Multi/04462/2013). M.J.C., D.G.F.F. and J.M. were supported by FCT (PhD grant SFRH/BD/131331/2017, PhD grant PD/BD/135484/2018 and postdoctoral contract PTDC/MED-TOX/30418/2017, respectively). |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-03-17T23:23:29Z 2022-02-01 2022-02-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/134771 |
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http://hdl.handle.net/10362/134771 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1420-3049 PURE: 42426585 https://doi.org/10.3390/molecules27041416 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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