Estimating Kidney Function in the Critically Ill Patients
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.16/1654 |
Resumo: | Glomerular filtration rate (GFR) is an accepted measure for assessment of kidney function. For the critically ill patient, creatinine clearance is the method of reference for the estimation of the GFR, although this is often not measured but estimated by equations (i.e., Cockroft-Gault or MDRD) not well suited for the critically ill patient. Functional evaluation of the kidney rests in serum creatinine (Crs) that is subjected to multiple external factors, especially relevant overhydration and loss of muscle mass. The laboratory method used introduces variations in Crs, an important fact considering that small increases in Crs have serious repercussion on the prognosis of patients. Efforts directed to stratify the risk of acute kidney injury (AKI) have crystallized in the RIFLE or AKIN systems, based in sequential changes in Crs or urine flow. These systems have provided a common definition of AKI and, due to their sensitivity, have meant a considerable advantage for the clinical practice but, on the other side, have introduced an uncertainty in clinical research because of potentially overestimating AKI incidence. Another significant drawback is the unavoidable period of time needed before a patient is classified, and this is perhaps the problem to be overcome in the near future. |
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Estimating Kidney Function in the Critically Ill PatientsGlomerular filtration rate (GFR) is an accepted measure for assessment of kidney function. For the critically ill patient, creatinine clearance is the method of reference for the estimation of the GFR, although this is often not measured but estimated by equations (i.e., Cockroft-Gault or MDRD) not well suited for the critically ill patient. Functional evaluation of the kidney rests in serum creatinine (Crs) that is subjected to multiple external factors, especially relevant overhydration and loss of muscle mass. The laboratory method used introduces variations in Crs, an important fact considering that small increases in Crs have serious repercussion on the prognosis of patients. Efforts directed to stratify the risk of acute kidney injury (AKI) have crystallized in the RIFLE or AKIN systems, based in sequential changes in Crs or urine flow. These systems have provided a common definition of AKI and, due to their sensitivity, have meant a considerable advantage for the clinical practice but, on the other side, have introduced an uncertainty in clinical research because of potentially overestimating AKI incidence. Another significant drawback is the unavoidable period of time needed before a patient is classified, and this is perhaps the problem to be overcome in the near future.Hindawi Publishing CorporationRepositório Científico do Centro Hospitalar Universitário de Santo AntónioSeller-Pérez, G.Herrera-Gutiérrez, M.Maynar-Moliner, J.Sánchez-Izquierdo-Riera, J.Marinho, A.do Pico, J.2014-09-02T08:25:45Z20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/1654engGemma Seller-Pérez, Manuel E. Herrera-Gutiérrez, Javier Maynar-Moliner, José A. Sánchez-Izquierdo-Riera, Anibal Marinho, and José Luis do Pico, “Estimating Kidney Function in the Critically Ill Patients,” Critical Care Research and Practice, vol. 2013, Article ID 721810, 6 pages, 2013. doi:10.1155/2013/72181010.1155/2013/721810info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-20T10:56:55Zoai:repositorio.chporto.pt:10400.16/1654Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:38:01.970927Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Estimating Kidney Function in the Critically Ill Patients |
title |
Estimating Kidney Function in the Critically Ill Patients |
spellingShingle |
Estimating Kidney Function in the Critically Ill Patients Seller-Pérez, G. |
title_short |
Estimating Kidney Function in the Critically Ill Patients |
title_full |
Estimating Kidney Function in the Critically Ill Patients |
title_fullStr |
Estimating Kidney Function in the Critically Ill Patients |
title_full_unstemmed |
Estimating Kidney Function in the Critically Ill Patients |
title_sort |
Estimating Kidney Function in the Critically Ill Patients |
author |
Seller-Pérez, G. |
author_facet |
Seller-Pérez, G. Herrera-Gutiérrez, M. Maynar-Moliner, J. Sánchez-Izquierdo-Riera, J. Marinho, A. do Pico, J. |
author_role |
author |
author2 |
Herrera-Gutiérrez, M. Maynar-Moliner, J. Sánchez-Izquierdo-Riera, J. Marinho, A. do Pico, J. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Centro Hospitalar Universitário de Santo António |
dc.contributor.author.fl_str_mv |
Seller-Pérez, G. Herrera-Gutiérrez, M. Maynar-Moliner, J. Sánchez-Izquierdo-Riera, J. Marinho, A. do Pico, J. |
description |
Glomerular filtration rate (GFR) is an accepted measure for assessment of kidney function. For the critically ill patient, creatinine clearance is the method of reference for the estimation of the GFR, although this is often not measured but estimated by equations (i.e., Cockroft-Gault or MDRD) not well suited for the critically ill patient. Functional evaluation of the kidney rests in serum creatinine (Crs) that is subjected to multiple external factors, especially relevant overhydration and loss of muscle mass. The laboratory method used introduces variations in Crs, an important fact considering that small increases in Crs have serious repercussion on the prognosis of patients. Efforts directed to stratify the risk of acute kidney injury (AKI) have crystallized in the RIFLE or AKIN systems, based in sequential changes in Crs or urine flow. These systems have provided a common definition of AKI and, due to their sensitivity, have meant a considerable advantage for the clinical practice but, on the other side, have introduced an uncertainty in clinical research because of potentially overestimating AKI incidence. Another significant drawback is the unavoidable period of time needed before a patient is classified, and this is perhaps the problem to be overcome in the near future. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013 2013-01-01T00:00:00Z 2014-09-02T08:25:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.16/1654 |
url |
http://hdl.handle.net/10400.16/1654 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Gemma Seller-Pérez, Manuel E. Herrera-Gutiérrez, Javier Maynar-Moliner, José A. Sánchez-Izquierdo-Riera, Anibal Marinho, and José Luis do Pico, “Estimating Kidney Function in the Critically Ill Patients,” Critical Care Research and Practice, vol. 2013, Article ID 721810, 6 pages, 2013. doi:10.1155/2013/721810 10.1155/2013/721810 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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