D-α-tocopheryl polyethylene glycol 1000 succinate functionalized nanographene oxide for cancer therapy

Detalhes bibliográficos
Autor(a) principal: Diogo, Duarte Miguel de Melo
Data de Publicação: 2017
Outros Autores: Silva, Cleide Isabel Pais, Costa, Elisabete C., Louro, Ricardo, Correia, Ilídio Joaquim Sobreira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/4694
Resumo: Aim: To evaluate the therapeutic capacity of D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)-functionalized nanographene oxide (nGO) in breast cancer cells. Methods: TPGS-functionalized nGO-based materials were obtained through two different approaches: a simple sonication method and a one-pot hydrothermal treatment. Results: TPGS coating successfully improved the stability of the nGO-based materials. The nanomaterials that underwent the hydrothermal procedure generated a 1.4- to 1.6-fold higher temperature variation under near infrared laser irradiation than those prepared only by sonication. In vitro, the TPGS/nGO derivatives reduced breast cancer cells’ viability and had an insignificant effect on healthy cells. Furthermore, the combined application of TPGS/nGO derivatives and near infrared light generated an improved therapeutic effect. Conclusion: TPGS/nGO derivatives are promising materials for breast cancer phototherapy.
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spelling D-α-tocopheryl polyethylene glycol 1000 succinate functionalized nanographene oxide for cancer therapyBreast cancerNanographene oxidePEGylated Vitamin EPhototherapyTPGSAim: To evaluate the therapeutic capacity of D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)-functionalized nanographene oxide (nGO) in breast cancer cells. Methods: TPGS-functionalized nGO-based materials were obtained through two different approaches: a simple sonication method and a one-pot hydrothermal treatment. Results: TPGS coating successfully improved the stability of the nGO-based materials. The nanomaterials that underwent the hydrothermal procedure generated a 1.4- to 1.6-fold higher temperature variation under near infrared laser irradiation than those prepared only by sonication. In vitro, the TPGS/nGO derivatives reduced breast cancer cells’ viability and had an insignificant effect on healthy cells. Furthermore, the combined application of TPGS/nGO derivatives and near infrared light generated an improved therapeutic effect. Conclusion: TPGS/nGO derivatives are promising materials for breast cancer phototherapy.Future MedicineuBibliorumDiogo, Duarte Miguel de MeloSilva, Cleide Isabel PaisCosta, Elisabete C.Louro, RicardoCorreia, Ilídio Joaquim Sobreira2018-03-22T08:57:29Z2017-02-092017-02-09T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/4694engde Melo-Diogo, D., Pais-Silva, C., Costa, E. C. e Correia, I. J (2017) “D-alpha-tocopheryl polyethylene glycol 1000 succinate functionalized nanographene oxide for cancer therapy.” Nanomedicine, Vol.12 (5), pp. 443-45610.2217/nnm-2016-0384metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-15T09:41:58Zoai:ubibliorum.ubi.pt:10400.6/4694Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:45:44.812047Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv D-α-tocopheryl polyethylene glycol 1000 succinate functionalized nanographene oxide for cancer therapy
title D-α-tocopheryl polyethylene glycol 1000 succinate functionalized nanographene oxide for cancer therapy
spellingShingle D-α-tocopheryl polyethylene glycol 1000 succinate functionalized nanographene oxide for cancer therapy
Diogo, Duarte Miguel de Melo
Breast cancer
Nanographene oxide
PEGylated Vitamin E
Phototherapy
TPGS
title_short D-α-tocopheryl polyethylene glycol 1000 succinate functionalized nanographene oxide for cancer therapy
title_full D-α-tocopheryl polyethylene glycol 1000 succinate functionalized nanographene oxide for cancer therapy
title_fullStr D-α-tocopheryl polyethylene glycol 1000 succinate functionalized nanographene oxide for cancer therapy
title_full_unstemmed D-α-tocopheryl polyethylene glycol 1000 succinate functionalized nanographene oxide for cancer therapy
title_sort D-α-tocopheryl polyethylene glycol 1000 succinate functionalized nanographene oxide for cancer therapy
author Diogo, Duarte Miguel de Melo
author_facet Diogo, Duarte Miguel de Melo
Silva, Cleide Isabel Pais
Costa, Elisabete C.
Louro, Ricardo
Correia, Ilídio Joaquim Sobreira
author_role author
author2 Silva, Cleide Isabel Pais
Costa, Elisabete C.
Louro, Ricardo
Correia, Ilídio Joaquim Sobreira
author2_role author
author
author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Diogo, Duarte Miguel de Melo
Silva, Cleide Isabel Pais
Costa, Elisabete C.
Louro, Ricardo
Correia, Ilídio Joaquim Sobreira
dc.subject.por.fl_str_mv Breast cancer
Nanographene oxide
PEGylated Vitamin E
Phototherapy
TPGS
topic Breast cancer
Nanographene oxide
PEGylated Vitamin E
Phototherapy
TPGS
description Aim: To evaluate the therapeutic capacity of D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)-functionalized nanographene oxide (nGO) in breast cancer cells. Methods: TPGS-functionalized nGO-based materials were obtained through two different approaches: a simple sonication method and a one-pot hydrothermal treatment. Results: TPGS coating successfully improved the stability of the nGO-based materials. The nanomaterials that underwent the hydrothermal procedure generated a 1.4- to 1.6-fold higher temperature variation under near infrared laser irradiation than those prepared only by sonication. In vitro, the TPGS/nGO derivatives reduced breast cancer cells’ viability and had an insignificant effect on healthy cells. Furthermore, the combined application of TPGS/nGO derivatives and near infrared light generated an improved therapeutic effect. Conclusion: TPGS/nGO derivatives are promising materials for breast cancer phototherapy.
publishDate 2017
dc.date.none.fl_str_mv 2017-02-09
2017-02-09T00:00:00Z
2018-03-22T08:57:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/4694
url http://hdl.handle.net/10400.6/4694
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv de Melo-Diogo, D., Pais-Silva, C., Costa, E. C. e Correia, I. J (2017) “D-alpha-tocopheryl polyethylene glycol 1000 succinate functionalized nanographene oxide for cancer therapy.” Nanomedicine, Vol.12 (5), pp. 443-456
10.2217/nnm-2016-0384
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Future Medicine
publisher.none.fl_str_mv Future Medicine
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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