Cystatin C: A Promising Marker of Renal Function in Patients with Systemic Lupus Erythematosus?
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5770 |
Resumo: | Purpose: Cystatin C has a higher correlation with glomerular filtration rate and a more significant clinical prognosis than creatinine. We sought to determine whether it is a marker of renal function different from creatinine (cystatin C potentially superior to creatinine), in patients with systemic lupus erythematosus.Material and Methods: 37 patients with systemic lupus erythematosus were evaluated. Serum cystatin C was determined by nephelometry and creatinine by modified Jaffe method. We compared five formulas: Chronic Kidney Disease – Epidemiology Collaboration cystiatin; Chronic Kidney Disease – Epidemiology Collaboration creatinine-cystatin; Cockcroft-Gault; Modification of Diet in Renal Disease and Chronic Kidney Disease – Epidemiology Collaboration creatinine, using the latter as a reference. We analyzed the influence of clinical and laboratory factors in cystatin C variation, using multivariate linear regression.Results: Cystatin C was singly elevated in ten participants, versus none isolated creatinine elevation, and this difference was significant (p = 0.002). There was a difference between the estimated glomerular filtration rate by Chronic Kidney Disease – Epidemiology Collaboration cystatin and by Chronic Kidney Disease – Epidemiology Collaboration creatinine (-6.0541 mL/min/1.73 m2, p = 0.07), more pronounced for lower glomerular filtration rate. Consequently, Chronic Kidney Disease – Epidemiology Collaboration cystatin reclassified 4 patients as having chronic kidney disease de novo and 1 patient as not having chronic kidney disease (p = 0.375).Cystatin C was only significantly influenced by age (p < 0.001).Discussion: Several reports showed cystatin C as a better marker to define chronic kidney disease, allowing more accurate classification and risk stratification, compared with creatinine. In this study, Cystatin C revealed as a promisor marker of renal function in patient with lupus, mainly in patients with lower glomerular filtration rates. The correlation between age and cystatin C seems to be a confoundingfactor, as glomerular filtration rate physiologically declines with ageing.Conclusion: Cystatin C was potentially superior to creatinine and in this study and cystatin C seems to detect changes in glomerular filtration rate earlier than creatinine and may be a better screening method for chronic kidney disease in systemic lupus erythematosus. |
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Cystatin C: A Promising Marker of Renal Function in Patients with Systemic Lupus Erythematosus?Cistatina C: Um Marcador de Função Renal Promissor em Doentes com Lúpus Eritematoso Sistémico?Biological MarkersCystatin CLupus ErythematosusRenal InsufficiencySystemic.Cistatina CInsuficiência RenalLúpus Eritematoso SistémicoMarcadores Biológicos.Purpose: Cystatin C has a higher correlation with glomerular filtration rate and a more significant clinical prognosis than creatinine. We sought to determine whether it is a marker of renal function different from creatinine (cystatin C potentially superior to creatinine), in patients with systemic lupus erythematosus.Material and Methods: 37 patients with systemic lupus erythematosus were evaluated. Serum cystatin C was determined by nephelometry and creatinine by modified Jaffe method. We compared five formulas: Chronic Kidney Disease – Epidemiology Collaboration cystiatin; Chronic Kidney Disease – Epidemiology Collaboration creatinine-cystatin; Cockcroft-Gault; Modification of Diet in Renal Disease and Chronic Kidney Disease – Epidemiology Collaboration creatinine, using the latter as a reference. We analyzed the influence of clinical and laboratory factors in cystatin C variation, using multivariate linear regression.Results: Cystatin C was singly elevated in ten participants, versus none isolated creatinine elevation, and this difference was significant (p = 0.002). There was a difference between the estimated glomerular filtration rate by Chronic Kidney Disease – Epidemiology Collaboration cystatin and by Chronic Kidney Disease – Epidemiology Collaboration creatinine (-6.0541 mL/min/1.73 m2, p = 0.07), more pronounced for lower glomerular filtration rate. Consequently, Chronic Kidney Disease – Epidemiology Collaboration cystatin reclassified 4 patients as having chronic kidney disease de novo and 1 patient as not having chronic kidney disease (p = 0.375).Cystatin C was only significantly influenced by age (p < 0.001).Discussion: Several reports showed cystatin C as a better marker to define chronic kidney disease, allowing more accurate classification and risk stratification, compared with creatinine. In this study, Cystatin C revealed as a promisor marker of renal function in patient with lupus, mainly in patients with lower glomerular filtration rates. The correlation between age and cystatin C seems to be a confoundingfactor, as glomerular filtration rate physiologically declines with ageing.Conclusion: Cystatin C was potentially superior to creatinine and in this study and cystatin C seems to detect changes in glomerular filtration rate earlier than creatinine and may be a better screening method for chronic kidney disease in systemic lupus erythematosus.Introdução: A cistatina C possui uma correlação superior com a taxa de filtrado glomerular e um prognóstico clínico mais significativo do que a creatinina. Procurou-se averiguar se constitui um marcador de função renal diferente da creatinina (cistatina C potencialmente superior à creatinina), em doentes com lúpus eritematoso sistémico.Material e Métodos: Foram avaliados 37 doentes com lúpus eritematoso sistémico, sem evidência de nefrite lúpica activa. Determinouse a cistatina C sérica por nefelometria e a creatinina pelo método de Jaffe modificado. Compararam-se cinco fórmulas: Chronic Kidney Disease – Epidemiology Collaboration cystatin; Chronic Kidney Disease – Epidemiology Collaboration creatinine-cystatin; Cockcroft-Gault, Modification of Diet in Renal Disease e Chronic Kidney Disease – Epidemiology creatinine, utilizando-se esta última como referência. Analisou-se a influência de factores clínicos e laboratoriais na variação da cistatina C, por regressão linear multivariada.Resultados: A cistatina C encontrava-se isoladamente elevada em dez participantes, ao invés de nenhuma elevação isolada dacreatinina, sendo esta diferença significativa (p = 0,002). Verificou-se uma diferença entre a taxa de filtrado glomerular estimada pela Chronic Kidney Disease – Epidemiology Collaboration cystatin e pela Chronic Kidney Disease – Epidemiology Collaboration creatinine (-6,0541 mL/min/1,73 m2, p = 0,07), mais acentuada para taxas de filtração glomerular mais baixas. Assim, a fórmula Chronic KidneyDisease – Epidemiology Collaboration cystatin reclassificou 4 doentes como tendo doença renal crónica de novo e um doente como não tendo doença renal crónica (p = 0,375). A cistatina C foi influenciada significativamente apenas pela idade (p < 0,001).Discussão: Vários estudos demonstraram que a cistatina C melhora a definição de doença renal crónica, permitindo uma classificação e uma estratificação do risco mais exactas, comparativamente à creatinina. A cistatina C revelou-se, neste estudo, um marcador de função renal promissor nos doentes com lupus, principalmente para taxas de filtrado glomerular mais baixas. A correlação da cistatina C com a idade para ser um factor confundente, na medida em que existe um declínio fisiológico da taxa de filtração glomerular com o envelhecimento.Conclusão: A cistatina C foi potencialmente superior à creatinina e nesta amostra a cistatina C pareceu detectar mais precocemente do que a creatinina alterações na taxa de filtrado glomerular, podendo ser um melhor método de rastreio de doença renal crónica no lúpus eritematoso sistémico.Ordem dos Médicos2015-06-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfapplication/mswordapplication/mswordapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5770oai:ojs.www.actamedicaportuguesa.com:article/5770Acta Médica Portuguesa; Vol. 28 No. 3 (2015): May-June; 333-341Acta Médica Portuguesa; Vol. 28 N.º 3 (2015): Maio-Junho; 333-3411646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5770https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5770/4360https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5770/4451https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5770/7568https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5770/7602https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5770/7731Peixoto, LígiaAguiar, PatrícioBragança, Raquel deMartins, Joana RosaAcabado, Alba JaneiroDucla-Sores, José Luísinfo:eu-repo/semantics/openAccess2022-12-20T11:04:29Zoai:ojs.www.actamedicaportuguesa.com:article/5770Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:09.914148Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Cystatin C: A Promising Marker of Renal Function in Patients with Systemic Lupus Erythematosus? Cistatina C: Um Marcador de Função Renal Promissor em Doentes com Lúpus Eritematoso Sistémico? |
title |
Cystatin C: A Promising Marker of Renal Function in Patients with Systemic Lupus Erythematosus? |
spellingShingle |
Cystatin C: A Promising Marker of Renal Function in Patients with Systemic Lupus Erythematosus? Peixoto, Lígia Biological Markers Cystatin C Lupus Erythematosus Renal Insufficiency Systemic. Cistatina C Insuficiência Renal Lúpus Eritematoso Sistémico Marcadores Biológicos. |
title_short |
Cystatin C: A Promising Marker of Renal Function in Patients with Systemic Lupus Erythematosus? |
title_full |
Cystatin C: A Promising Marker of Renal Function in Patients with Systemic Lupus Erythematosus? |
title_fullStr |
Cystatin C: A Promising Marker of Renal Function in Patients with Systemic Lupus Erythematosus? |
title_full_unstemmed |
Cystatin C: A Promising Marker of Renal Function in Patients with Systemic Lupus Erythematosus? |
title_sort |
Cystatin C: A Promising Marker of Renal Function in Patients with Systemic Lupus Erythematosus? |
author |
Peixoto, Lígia |
author_facet |
Peixoto, Lígia Aguiar, Patrício Bragança, Raquel de Martins, Joana Rosa Acabado, Alba Janeiro Ducla-Sores, José Luís |
author_role |
author |
author2 |
Aguiar, Patrício Bragança, Raquel de Martins, Joana Rosa Acabado, Alba Janeiro Ducla-Sores, José Luís |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Peixoto, Lígia Aguiar, Patrício Bragança, Raquel de Martins, Joana Rosa Acabado, Alba Janeiro Ducla-Sores, José Luís |
dc.subject.por.fl_str_mv |
Biological Markers Cystatin C Lupus Erythematosus Renal Insufficiency Systemic. Cistatina C Insuficiência Renal Lúpus Eritematoso Sistémico Marcadores Biológicos. |
topic |
Biological Markers Cystatin C Lupus Erythematosus Renal Insufficiency Systemic. Cistatina C Insuficiência Renal Lúpus Eritematoso Sistémico Marcadores Biológicos. |
description |
Purpose: Cystatin C has a higher correlation with glomerular filtration rate and a more significant clinical prognosis than creatinine. We sought to determine whether it is a marker of renal function different from creatinine (cystatin C potentially superior to creatinine), in patients with systemic lupus erythematosus.Material and Methods: 37 patients with systemic lupus erythematosus were evaluated. Serum cystatin C was determined by nephelometry and creatinine by modified Jaffe method. We compared five formulas: Chronic Kidney Disease – Epidemiology Collaboration cystiatin; Chronic Kidney Disease – Epidemiology Collaboration creatinine-cystatin; Cockcroft-Gault; Modification of Diet in Renal Disease and Chronic Kidney Disease – Epidemiology Collaboration creatinine, using the latter as a reference. We analyzed the influence of clinical and laboratory factors in cystatin C variation, using multivariate linear regression.Results: Cystatin C was singly elevated in ten participants, versus none isolated creatinine elevation, and this difference was significant (p = 0.002). There was a difference between the estimated glomerular filtration rate by Chronic Kidney Disease – Epidemiology Collaboration cystatin and by Chronic Kidney Disease – Epidemiology Collaboration creatinine (-6.0541 mL/min/1.73 m2, p = 0.07), more pronounced for lower glomerular filtration rate. Consequently, Chronic Kidney Disease – Epidemiology Collaboration cystatin reclassified 4 patients as having chronic kidney disease de novo and 1 patient as not having chronic kidney disease (p = 0.375).Cystatin C was only significantly influenced by age (p < 0.001).Discussion: Several reports showed cystatin C as a better marker to define chronic kidney disease, allowing more accurate classification and risk stratification, compared with creatinine. In this study, Cystatin C revealed as a promisor marker of renal function in patient with lupus, mainly in patients with lower glomerular filtration rates. The correlation between age and cystatin C seems to be a confoundingfactor, as glomerular filtration rate physiologically declines with ageing.Conclusion: Cystatin C was potentially superior to creatinine and in this study and cystatin C seems to detect changes in glomerular filtration rate earlier than creatinine and may be a better screening method for chronic kidney disease in systemic lupus erythematosus. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-06-03 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5770 oai:ojs.www.actamedicaportuguesa.com:article/5770 |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5770 |
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oai:ojs.www.actamedicaportuguesa.com:article/5770 |
dc.language.iso.fl_str_mv |
por eng |
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por eng |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5770 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5770/4360 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5770/4451 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5770/7568 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5770/7602 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5770/7731 |
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Ordem dos Médicos |
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Ordem dos Médicos |
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Acta Médica Portuguesa; Vol. 28 No. 3 (2015): May-June; 333-341 Acta Médica Portuguesa; Vol. 28 N.º 3 (2015): Maio-Junho; 333-341 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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