Remarkable diversity of intron-1 of the para voltage-gated sodium channel gene in an Anopheles gambiae/Anopheles coluzzii hybrid zone
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | https://doi.org/10.1186/s12936-014-0522-1 |
Resumo: | PMID: 25604888 WOS:000348875400001 |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Remarkable diversity of intron-1 of the para voltage-gated sodium channel gene in an Anopheles gambiae/Anopheles coluzzii hybrid zoneHybridizationMalariaMosquitoGeneticsEcology, Evolution, Behavior and SystematicsInfectious DiseasesInsect ScienceSDG 3 - Good Health and Well-beingSDG 15 - Life on LandPMID: 25604888 WOS:000348875400001Background: Genomic differentiation between Anopheles gambiae and Anopheles coluzzii - the major malaria vectors in sub-Saharan Africa - is localized into large "islands" toward the centromeres of chromosome-X and the two autosomes. Linkage disequilibrium between these genomic islands was first detected between species-specific polymorphisms within ribosomal DNA genes (IGS-rDNA) on the X-chromosome and a single variant at position 702 of intron 1 (Int-1702) of the para Voltage-Gated Sodium Channel (VGSC) gene on chromosome arm 2 L. Intron-1 sequence data from West and Central Africa revealed two clearly distinct and species-specific haplogroups, each characterized by very low polymorphism, which has been attributed to a selective sweep. The aim of this study was to analyse Int-1 sequence diversity in A. gambiae and A. coluzzii populations from the Far-West of their range, in order to assess whether this selective-sweep signature could persist in a zone of high interspecific hybridization. Methods: A 531 bp region of VGSC Int-1 was sequenced in 21 A. coluzzii, 31 A. gambiae, and 12 hybrids from The Gambia and Guinea Bissau, located within the Far-West geographical region, and in 53 A. gambiae s.l. samples from the rest of the range. Results: Far-West samples exhibit dramatic Int-1 polymorphism, far higher within each country than observed throughout the rest of the species range. Moreover, patterning of haplotypes within A. coluzzii confirms previous evidence of a macro-geographic subdivision into a West and a Central African genetic cluster, and reveals a possible genetic distinction of A. coluzzii populations from the Far-West. Conclusions: The results suggest a relaxation of selective pressures acting across the VGSC gene region in the hybrid zone. Genetic differentiation in the Far-West could be attributable to a founder effect within A. coluzzii, with subsequent extensive gene flow with secondarily-colonizing A. gambiae, potentially yielding a novel insight on the dynamic processes impacting genetic divergence of these key malaria vectors.Instituto de Higiene e Medicina Tropical (IHMT)Centro de Malária e outras Doenças Tropicais (CMDT)RUNSantolamazza, FedericaCaputo, BeniaminoNwakanma, Davis C.Fanello, CaterinaPetrarca, VincenzoConway, David J.Weetman, DavidPinto, JoaoMancini, EmilianoDella Torre, Alessandra2018-05-14T22:02:30Z2015-01-212015-01-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10application/pdfhttps://doi.org/10.1186/s12936-014-0522-1engPURE: 1732492http://www.scopus.com/inward/record.url?scp=84934889859&partnerID=8YFLogxKhttps://doi.org/10.1186/s12936-014-0522-1info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:20:30Zoai:run.unl.pt:10362/36947Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:30:43.431661Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Remarkable diversity of intron-1 of the para voltage-gated sodium channel gene in an Anopheles gambiae/Anopheles coluzzii hybrid zone |
| title |
Remarkable diversity of intron-1 of the para voltage-gated sodium channel gene in an Anopheles gambiae/Anopheles coluzzii hybrid zone |
| spellingShingle |
Remarkable diversity of intron-1 of the para voltage-gated sodium channel gene in an Anopheles gambiae/Anopheles coluzzii hybrid zone Santolamazza, Federica Hybridization Malaria Mosquito Genetics Ecology, Evolution, Behavior and Systematics Infectious Diseases Insect Science SDG 3 - Good Health and Well-being SDG 15 - Life on Land |
| title_short |
Remarkable diversity of intron-1 of the para voltage-gated sodium channel gene in an Anopheles gambiae/Anopheles coluzzii hybrid zone |
| title_full |
Remarkable diversity of intron-1 of the para voltage-gated sodium channel gene in an Anopheles gambiae/Anopheles coluzzii hybrid zone |
| title_fullStr |
Remarkable diversity of intron-1 of the para voltage-gated sodium channel gene in an Anopheles gambiae/Anopheles coluzzii hybrid zone |
| title_full_unstemmed |
Remarkable diversity of intron-1 of the para voltage-gated sodium channel gene in an Anopheles gambiae/Anopheles coluzzii hybrid zone |
| title_sort |
Remarkable diversity of intron-1 of the para voltage-gated sodium channel gene in an Anopheles gambiae/Anopheles coluzzii hybrid zone |
| author |
Santolamazza, Federica |
| author_facet |
Santolamazza, Federica Caputo, Beniamino Nwakanma, Davis C. Fanello, Caterina Petrarca, Vincenzo Conway, David J. Weetman, David Pinto, Joao Mancini, Emiliano Della Torre, Alessandra |
| author_role |
author |
| author2 |
Caputo, Beniamino Nwakanma, Davis C. Fanello, Caterina Petrarca, Vincenzo Conway, David J. Weetman, David Pinto, Joao Mancini, Emiliano Della Torre, Alessandra |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Higiene e Medicina Tropical (IHMT) Centro de Malária e outras Doenças Tropicais (CMDT) RUN |
| dc.contributor.author.fl_str_mv |
Santolamazza, Federica Caputo, Beniamino Nwakanma, Davis C. Fanello, Caterina Petrarca, Vincenzo Conway, David J. Weetman, David Pinto, Joao Mancini, Emiliano Della Torre, Alessandra |
| dc.subject.por.fl_str_mv |
Hybridization Malaria Mosquito Genetics Ecology, Evolution, Behavior and Systematics Infectious Diseases Insect Science SDG 3 - Good Health and Well-being SDG 15 - Life on Land |
| topic |
Hybridization Malaria Mosquito Genetics Ecology, Evolution, Behavior and Systematics Infectious Diseases Insect Science SDG 3 - Good Health and Well-being SDG 15 - Life on Land |
| description |
PMID: 25604888 WOS:000348875400001 |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015-01-21 2015-01-21T00:00:00Z 2018-05-14T22:02:30Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://doi.org/10.1186/s12936-014-0522-1 |
| url |
https://doi.org/10.1186/s12936-014-0522-1 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
PURE: 1732492 http://www.scopus.com/inward/record.url?scp=84934889859&partnerID=8YFLogxK https://doi.org/10.1186/s12936-014-0522-1 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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10 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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