Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy

Detalhes bibliográficos
Autor(a) principal: Silva, Susana L.
Data de Publicação: 2017
Outros Autores: Albuquerque, Adriana, Amaral, Andreia J., Li, Quan-Zhen, Mota, Catarina, Cheynier, Rémi, Victorino, Rui M. M., Santos, M. Conceição Pereira, Sousa, Ana E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/28769
Resumo: © 2017 Silva et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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spelling Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy© 2017 Silva et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.The contribution of the decline in thymic activity for the emergence of autoimmunity is still debatable. Immune-competent adults submitted to complete thymectomy early in life provide a unique model to address this question. We applied here strict criteria to identify adults lacking thymic activity based on sjTREC levels, to exclude thymic rebound and/or ectopic thymuses. In agreement, they featured severe naïve CD4 T-cell depletion and contraction of T-cell receptor diversity. Notwithstanding this, there was neither increased incidence of autoimmune disease in comparison with age-matched controls nor significant changes in their IgG/IgA/IgM/IgE autoreactivity profiles, as assessed through extensive arrays. We reasoned that the observed relative preservation of the regulatory T-cell compartment, including maintenance of naïve regulatory CD4 T-cells, may contribute to limit the emergence of autoimmunity upon thymectomy. Our findings have implications in other clinical settings with impaired thymic activity, and are particularly relevant to studies of autoimmunity in ageing.This work was supported by Fundação para a Ciência e Tecnologia (FCT; POCI2010/IC/83068/2007 to RMMV; PTDC/SAU-MIC/109786/2009 to AES), and Gulbenkian Foundation (P132532/2013 to AES). SLS, ASA and AJA received FCT scholarships. AJA was supported by an EMBO long-term fellowship (ALT-33-2010) and a Marie Curie European Integration Grant (PERGGA-2009-256595).Public Library of ScienceRepositório da Universidade de LisboaSilva, Susana L.Albuquerque, AdrianaAmaral, Andreia J.Li, Quan-ZhenMota, CatarinaCheynier, RémiVictorino, Rui M. M.Santos, M. Conceição PereiraSousa, Ana E.2017-08-24T13:25:43Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/28769engPLOS ONE | July 7, 20171932-620310.1371/journal.pone.0180385info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:20:49Zoai:repositorio.ul.pt:10451/28769Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:44:56.045157Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy
title Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy
spellingShingle Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy
Silva, Susana L.
title_short Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy
title_full Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy
title_fullStr Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy
title_full_unstemmed Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy
title_sort Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy
author Silva, Susana L.
author_facet Silva, Susana L.
Albuquerque, Adriana
Amaral, Andreia J.
Li, Quan-Zhen
Mota, Catarina
Cheynier, Rémi
Victorino, Rui M. M.
Santos, M. Conceição Pereira
Sousa, Ana E.
author_role author
author2 Albuquerque, Adriana
Amaral, Andreia J.
Li, Quan-Zhen
Mota, Catarina
Cheynier, Rémi
Victorino, Rui M. M.
Santos, M. Conceição Pereira
Sousa, Ana E.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Silva, Susana L.
Albuquerque, Adriana
Amaral, Andreia J.
Li, Quan-Zhen
Mota, Catarina
Cheynier, Rémi
Victorino, Rui M. M.
Santos, M. Conceição Pereira
Sousa, Ana E.
description © 2017 Silva et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
publishDate 2017
dc.date.none.fl_str_mv 2017-08-24T13:25:43Z
2017
2017-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/28769
url http://hdl.handle.net/10451/28769
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PLOS ONE | July 7, 2017
1932-6203
10.1371/journal.pone.0180385
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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