Staphylococcus aureus causing skin and soft tissue infections in companion animals : antimicrobial resistance profiles and clonal lineages

Detalhes bibliográficos
Autor(a) principal: Costa, Sofia Santos
Data de Publicação: 2022
Outros Autores: Rute, Ribeiro, Serrano, Maria, Oliveira, Ketlyn, Ferreira, Carolina, Leal, Marta, Pomba, C., Couto, Isabel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/24810
Resumo: Research Areas: Infectious Diseases ; Pharmacology & Pharmacy
id RCAP_103a15280c112fcf06ca93474f3f21b5
oai_identifier_str oai:repositorio.ul.pt:10400.5/24810
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Staphylococcus aureus causing skin and soft tissue infections in companion animals : antimicrobial resistance profiles and clonal lineagesStaphylococcus aureusMRSACompanion animalsAntimicrobial resistanceHeavy metalsClonal lineagesOne HealthResearch Areas: Infectious Diseases ; Pharmacology & PharmacyABSTRACT - Staphylococcus aureus is a relevant agent of skin and soft tissue infections (SSTIs) in animals. Fifty-five S. aureus comprising all SSTI-related isolates in companion animals, collected between 1999 and 2018 (Lab 1) or 2017 and 2018 (Lab 2), were characterized regarding susceptibility to antibiotics and heavy metals and carriage of antimicrobial resistance determinants. Clonal lineages were established by PFGE, MLST and agr typing. Over half of the isolates (56.4%, 31/55) were methicillin-resistant S. aureus (MRSA), and 14.5% showed a multidrug resistance (MDR) phenotype. Resistance was most frequently observed for beta-lactams (81.8%, related to blaZ and/or mecA), fluoroquinolones (56.4%) and macrolides/lincosamides (14.5%, related to erm(A) or erm(C)). The distributions of heavy-metal MICs allowed the detection of non-wild-type populations associated with several resistance genes. The collection showed genetic diversity, with prevalence of clonal lineage ST22-agrI (45.5%, 25/55), comprising only MRSA isolates, and several less frequently detected clones, including ST5-agrII (14.6%, 8/55), ST398-agrI (9.1%, 5/55) and ST72-agrI (7.3%, 4/55). This work highlights the high frequency of SSTI-related MRSA strains that reflect the clonal lineages circulating both in companion animals and humans in Portugal, reinforcing the need for a One Health approach when studying staphylococci causing infections in companion animals.MDPIRepositório da Universidade de LisboaCosta, Sofia SantosRute, RibeiroSerrano, MariaOliveira, KetlynFerreira, CarolinaLeal, MartaPomba, C.Couto, Isabel2022-07-11T14:44:25Z2022-04-292022-04-29T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/24810engCosta SS, Ribeiro R, Serrano M, Oliveira K, Ferreira C, Leal M, Pomba C, Couto I. 2022. Staphylococcus aureus Causing Skin and Soft Tissue Infections in Companion Animals: Antimicrobial Resistance Profiles and Clonal Lineages. Antibiotics, 11(5):599. DOI: https://doi.org/10.3390/ antibiotics110505992079-6382https://doi.org/10.3390/ antibiotics11050599info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T18:35:56Zoai:repositorio.ul.pt:10400.5/24810Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T18:35:56Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Staphylococcus aureus causing skin and soft tissue infections in companion animals : antimicrobial resistance profiles and clonal lineages
title Staphylococcus aureus causing skin and soft tissue infections in companion animals : antimicrobial resistance profiles and clonal lineages
spellingShingle Staphylococcus aureus causing skin and soft tissue infections in companion animals : antimicrobial resistance profiles and clonal lineages
Costa, Sofia Santos
Staphylococcus aureus
MRSA
Companion animals
Antimicrobial resistance
Heavy metals
Clonal lineages
One Health
title_short Staphylococcus aureus causing skin and soft tissue infections in companion animals : antimicrobial resistance profiles and clonal lineages
title_full Staphylococcus aureus causing skin and soft tissue infections in companion animals : antimicrobial resistance profiles and clonal lineages
title_fullStr Staphylococcus aureus causing skin and soft tissue infections in companion animals : antimicrobial resistance profiles and clonal lineages
title_full_unstemmed Staphylococcus aureus causing skin and soft tissue infections in companion animals : antimicrobial resistance profiles and clonal lineages
title_sort Staphylococcus aureus causing skin and soft tissue infections in companion animals : antimicrobial resistance profiles and clonal lineages
author Costa, Sofia Santos
author_facet Costa, Sofia Santos
Rute, Ribeiro
Serrano, Maria
Oliveira, Ketlyn
Ferreira, Carolina
Leal, Marta
Pomba, C.
Couto, Isabel
author_role author
author2 Rute, Ribeiro
Serrano, Maria
Oliveira, Ketlyn
Ferreira, Carolina
Leal, Marta
Pomba, C.
Couto, Isabel
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Costa, Sofia Santos
Rute, Ribeiro
Serrano, Maria
Oliveira, Ketlyn
Ferreira, Carolina
Leal, Marta
Pomba, C.
Couto, Isabel
dc.subject.por.fl_str_mv Staphylococcus aureus
MRSA
Companion animals
Antimicrobial resistance
Heavy metals
Clonal lineages
One Health
topic Staphylococcus aureus
MRSA
Companion animals
Antimicrobial resistance
Heavy metals
Clonal lineages
One Health
description Research Areas: Infectious Diseases ; Pharmacology & Pharmacy
publishDate 2022
dc.date.none.fl_str_mv 2022-07-11T14:44:25Z
2022-04-29
2022-04-29T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/24810
url http://hdl.handle.net/10400.5/24810
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Costa SS, Ribeiro R, Serrano M, Oliveira K, Ferreira C, Leal M, Pomba C, Couto I. 2022. Staphylococcus aureus Causing Skin and Soft Tissue Infections in Companion Animals: Antimicrobial Resistance Profiles and Clonal Lineages. Antibiotics, 11(5):599. DOI: https://doi.org/10.3390/ antibiotics11050599
2079-6382
https://doi.org/10.3390/ antibiotics11050599
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
_version_ 1817549320039170048