Staphylococcus aureus causing skin and soft tissue infections in companion animals : antimicrobial resistance profiles and clonal lineages
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.5/24810 |
Resumo: | Research Areas: Infectious Diseases ; Pharmacology & Pharmacy |
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7160 |
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Staphylococcus aureus causing skin and soft tissue infections in companion animals : antimicrobial resistance profiles and clonal lineagesStaphylococcus aureusMRSACompanion animalsAntimicrobial resistanceHeavy metalsClonal lineagesOne HealthResearch Areas: Infectious Diseases ; Pharmacology & PharmacyABSTRACT - Staphylococcus aureus is a relevant agent of skin and soft tissue infections (SSTIs) in animals. Fifty-five S. aureus comprising all SSTI-related isolates in companion animals, collected between 1999 and 2018 (Lab 1) or 2017 and 2018 (Lab 2), were characterized regarding susceptibility to antibiotics and heavy metals and carriage of antimicrobial resistance determinants. Clonal lineages were established by PFGE, MLST and agr typing. Over half of the isolates (56.4%, 31/55) were methicillin-resistant S. aureus (MRSA), and 14.5% showed a multidrug resistance (MDR) phenotype. Resistance was most frequently observed for beta-lactams (81.8%, related to blaZ and/or mecA), fluoroquinolones (56.4%) and macrolides/lincosamides (14.5%, related to erm(A) or erm(C)). The distributions of heavy-metal MICs allowed the detection of non-wild-type populations associated with several resistance genes. The collection showed genetic diversity, with prevalence of clonal lineage ST22-agrI (45.5%, 25/55), comprising only MRSA isolates, and several less frequently detected clones, including ST5-agrII (14.6%, 8/55), ST398-agrI (9.1%, 5/55) and ST72-agrI (7.3%, 4/55). This work highlights the high frequency of SSTI-related MRSA strains that reflect the clonal lineages circulating both in companion animals and humans in Portugal, reinforcing the need for a One Health approach when studying staphylococci causing infections in companion animals.MDPIRepositório da Universidade de LisboaCosta, Sofia SantosRute, RibeiroSerrano, MariaOliveira, KetlynFerreira, CarolinaLeal, MartaPomba, C.Couto, Isabel2022-07-11T14:44:25Z2022-04-292022-04-29T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/24810engCosta SS, Ribeiro R, Serrano M, Oliveira K, Ferreira C, Leal M, Pomba C, Couto I. 2022. Staphylococcus aureus Causing Skin and Soft Tissue Infections in Companion Animals: Antimicrobial Resistance Profiles and Clonal Lineages. Antibiotics, 11(5):599. DOI: https://doi.org/10.3390/ antibiotics110505992079-6382https://doi.org/10.3390/ antibiotics11050599info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:54:28Zoai:www.repository.utl.pt:10400.5/24810Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:08:46.449206Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Staphylococcus aureus causing skin and soft tissue infections in companion animals : antimicrobial resistance profiles and clonal lineages |
title |
Staphylococcus aureus causing skin and soft tissue infections in companion animals : antimicrobial resistance profiles and clonal lineages |
spellingShingle |
Staphylococcus aureus causing skin and soft tissue infections in companion animals : antimicrobial resistance profiles and clonal lineages Costa, Sofia Santos Staphylococcus aureus MRSA Companion animals Antimicrobial resistance Heavy metals Clonal lineages One Health |
title_short |
Staphylococcus aureus causing skin and soft tissue infections in companion animals : antimicrobial resistance profiles and clonal lineages |
title_full |
Staphylococcus aureus causing skin and soft tissue infections in companion animals : antimicrobial resistance profiles and clonal lineages |
title_fullStr |
Staphylococcus aureus causing skin and soft tissue infections in companion animals : antimicrobial resistance profiles and clonal lineages |
title_full_unstemmed |
Staphylococcus aureus causing skin and soft tissue infections in companion animals : antimicrobial resistance profiles and clonal lineages |
title_sort |
Staphylococcus aureus causing skin and soft tissue infections in companion animals : antimicrobial resistance profiles and clonal lineages |
author |
Costa, Sofia Santos |
author_facet |
Costa, Sofia Santos Rute, Ribeiro Serrano, Maria Oliveira, Ketlyn Ferreira, Carolina Leal, Marta Pomba, C. Couto, Isabel |
author_role |
author |
author2 |
Rute, Ribeiro Serrano, Maria Oliveira, Ketlyn Ferreira, Carolina Leal, Marta Pomba, C. Couto, Isabel |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Costa, Sofia Santos Rute, Ribeiro Serrano, Maria Oliveira, Ketlyn Ferreira, Carolina Leal, Marta Pomba, C. Couto, Isabel |
dc.subject.por.fl_str_mv |
Staphylococcus aureus MRSA Companion animals Antimicrobial resistance Heavy metals Clonal lineages One Health |
topic |
Staphylococcus aureus MRSA Companion animals Antimicrobial resistance Heavy metals Clonal lineages One Health |
description |
Research Areas: Infectious Diseases ; Pharmacology & Pharmacy |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-07-11T14:44:25Z 2022-04-29 2022-04-29T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.5/24810 |
url |
http://hdl.handle.net/10400.5/24810 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Costa SS, Ribeiro R, Serrano M, Oliveira K, Ferreira C, Leal M, Pomba C, Couto I. 2022. Staphylococcus aureus Causing Skin and Soft Tissue Infections in Companion Animals: Antimicrobial Resistance Profiles and Clonal Lineages. Antibiotics, 11(5):599. DOI: https://doi.org/10.3390/ antibiotics11050599 2079-6382 https://doi.org/10.3390/ antibiotics11050599 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1817550138720124928 |