Effect of multiple micronutrient supplements vs iron and folic acid supplements on neonatal mortality

Detalhes bibliográficos
Autor(a) principal: Gomes, Filomena
Data de Publicação: 2022
Outros Autores: Agustina, Rina, Black, Robert E., Christian, Parul, Dewey, Kathryn G., Kraemer, Klaus, Shankar, Anuraj H., Smith, Emily, Tumilowicz, Alison, Bourassa, Megan W.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/139413
Resumo: Publisher Copyright: © The Authors 2022.
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spelling Effect of multiple micronutrient supplements vs iron and folic acid supplements on neonatal mortalityA reanalysis by iron doseironKeywords:micronutrient supplementsneonatal mortalitypregnancyMedicine (miscellaneous)Nutrition and DieteticsPublic Health, Environmental and Occupational HealthSDG 3 - Good Health and Well-beingPublisher Copyright: © The Authors 2022.Objective Antenatal multiple micronutrient supplements (MMS) are a cost-effective intervention to reduce adverse pregnancy and birth outcomes. However, the current WHO recommendation on the use of antenatal MMS is conditional, partly due to concerns about the effect on neonatal mortality in a subgroup of studies comparing MMS with iron and folic acid supplements (IFA) containing 60 mg of iron. We aimed to assess the effect of MMS vs IFA on neonatal mortality stratified by iron dose in each supplement. Methods We updated the neonatal mortality analysis of the 2020 WHO guidelines using the generic inverse variance method and applied the random effects model to calculate the effect estimates of MMS vs. IFA on neonatal mortality in subgroups of trials (n=13) providing the same or different amounts of iron, i.e. MMS with 60 mg of iron vs IFA with 60 mg of iron; MMS with 30 mg of iron vs IFA with 30 mg of iron; MMS with 30 mg of iron vs IFA with 60 mg of iron; and MMS with 20 mg of iron vs IFA with 60 mg of iron. Results There were no statistically significant differences in neonatal mortality between MMS and IFA within any of the subgroups of trials. Analysis of MMS with 30 mg vs IFA with 60 mg of iron (7 trials, 14,114 participants), yielded a nonsignificant Risk Ratio (RR) of 1.12 (95% CI 0.83 to 1.50). Conclusion Neonatal mortality did not differ between MMS and IFA regardless of iron dose in either supplement.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNGomes, FilomenaAgustina, RinaBlack, Robert E.Christian, ParulDewey, Kathryn G.Kraemer, KlausShankar, Anuraj H.Smith, EmilyTumilowicz, AlisonBourassa, Megan W.2022-06-03T22:31:29Z2022-082022-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/139413eng1368-9800PURE: 44303511https://doi.org/10.1017/S1368980022001008info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:16:46Zoai:run.unl.pt:10362/139413Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:49:26.611640Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Effect of multiple micronutrient supplements vs iron and folic acid supplements on neonatal mortality
A reanalysis by iron dose
title Effect of multiple micronutrient supplements vs iron and folic acid supplements on neonatal mortality
spellingShingle Effect of multiple micronutrient supplements vs iron and folic acid supplements on neonatal mortality
Gomes, Filomena
iron
Keywords:
micronutrient supplements
neonatal mortality
pregnancy
Medicine (miscellaneous)
Nutrition and Dietetics
Public Health, Environmental and Occupational Health
SDG 3 - Good Health and Well-being
title_short Effect of multiple micronutrient supplements vs iron and folic acid supplements on neonatal mortality
title_full Effect of multiple micronutrient supplements vs iron and folic acid supplements on neonatal mortality
title_fullStr Effect of multiple micronutrient supplements vs iron and folic acid supplements on neonatal mortality
title_full_unstemmed Effect of multiple micronutrient supplements vs iron and folic acid supplements on neonatal mortality
title_sort Effect of multiple micronutrient supplements vs iron and folic acid supplements on neonatal mortality
author Gomes, Filomena
author_facet Gomes, Filomena
Agustina, Rina
Black, Robert E.
Christian, Parul
Dewey, Kathryn G.
Kraemer, Klaus
Shankar, Anuraj H.
Smith, Emily
Tumilowicz, Alison
Bourassa, Megan W.
author_role author
author2 Agustina, Rina
Black, Robert E.
Christian, Parul
Dewey, Kathryn G.
Kraemer, Klaus
Shankar, Anuraj H.
Smith, Emily
Tumilowicz, Alison
Bourassa, Megan W.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Gomes, Filomena
Agustina, Rina
Black, Robert E.
Christian, Parul
Dewey, Kathryn G.
Kraemer, Klaus
Shankar, Anuraj H.
Smith, Emily
Tumilowicz, Alison
Bourassa, Megan W.
dc.subject.por.fl_str_mv iron
Keywords:
micronutrient supplements
neonatal mortality
pregnancy
Medicine (miscellaneous)
Nutrition and Dietetics
Public Health, Environmental and Occupational Health
SDG 3 - Good Health and Well-being
topic iron
Keywords:
micronutrient supplements
neonatal mortality
pregnancy
Medicine (miscellaneous)
Nutrition and Dietetics
Public Health, Environmental and Occupational Health
SDG 3 - Good Health and Well-being
description Publisher Copyright: © The Authors 2022.
publishDate 2022
dc.date.none.fl_str_mv 2022-06-03T22:31:29Z
2022-08
2022-08-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/139413
url http://hdl.handle.net/10362/139413
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1368-9800
PURE: 44303511
https://doi.org/10.1017/S1368980022001008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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