Effect of multiple micronutrient supplements vs iron and folic acid supplements on neonatal mortality
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/139413 |
Resumo: | Publisher Copyright: © The Authors 2022. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Effect of multiple micronutrient supplements vs iron and folic acid supplements on neonatal mortalityA reanalysis by iron doseironKeywords:micronutrient supplementsneonatal mortalitypregnancyMedicine (miscellaneous)Nutrition and DieteticsPublic Health, Environmental and Occupational HealthSDG 3 - Good Health and Well-beingPublisher Copyright: © The Authors 2022.Objective Antenatal multiple micronutrient supplements (MMS) are a cost-effective intervention to reduce adverse pregnancy and birth outcomes. However, the current WHO recommendation on the use of antenatal MMS is conditional, partly due to concerns about the effect on neonatal mortality in a subgroup of studies comparing MMS with iron and folic acid supplements (IFA) containing 60 mg of iron. We aimed to assess the effect of MMS vs IFA on neonatal mortality stratified by iron dose in each supplement. Methods We updated the neonatal mortality analysis of the 2020 WHO guidelines using the generic inverse variance method and applied the random effects model to calculate the effect estimates of MMS vs. IFA on neonatal mortality in subgroups of trials (n=13) providing the same or different amounts of iron, i.e. MMS with 60 mg of iron vs IFA with 60 mg of iron; MMS with 30 mg of iron vs IFA with 30 mg of iron; MMS with 30 mg of iron vs IFA with 60 mg of iron; and MMS with 20 mg of iron vs IFA with 60 mg of iron. Results There were no statistically significant differences in neonatal mortality between MMS and IFA within any of the subgroups of trials. Analysis of MMS with 30 mg vs IFA with 60 mg of iron (7 trials, 14,114 participants), yielded a nonsignificant Risk Ratio (RR) of 1.12 (95% CI 0.83 to 1.50). Conclusion Neonatal mortality did not differ between MMS and IFA regardless of iron dose in either supplement.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNGomes, FilomenaAgustina, RinaBlack, Robert E.Christian, ParulDewey, Kathryn G.Kraemer, KlausShankar, Anuraj H.Smith, EmilyTumilowicz, AlisonBourassa, Megan W.2022-06-03T22:31:29Z2022-082022-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/139413eng1368-9800PURE: 44303511https://doi.org/10.1017/S1368980022001008info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:16:46Zoai:run.unl.pt:10362/139413Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:49:26.611640Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Effect of multiple micronutrient supplements vs iron and folic acid supplements on neonatal mortality A reanalysis by iron dose |
title |
Effect of multiple micronutrient supplements vs iron and folic acid supplements on neonatal mortality |
spellingShingle |
Effect of multiple micronutrient supplements vs iron and folic acid supplements on neonatal mortality Gomes, Filomena iron Keywords: micronutrient supplements neonatal mortality pregnancy Medicine (miscellaneous) Nutrition and Dietetics Public Health, Environmental and Occupational Health SDG 3 - Good Health and Well-being |
title_short |
Effect of multiple micronutrient supplements vs iron and folic acid supplements on neonatal mortality |
title_full |
Effect of multiple micronutrient supplements vs iron and folic acid supplements on neonatal mortality |
title_fullStr |
Effect of multiple micronutrient supplements vs iron and folic acid supplements on neonatal mortality |
title_full_unstemmed |
Effect of multiple micronutrient supplements vs iron and folic acid supplements on neonatal mortality |
title_sort |
Effect of multiple micronutrient supplements vs iron and folic acid supplements on neonatal mortality |
author |
Gomes, Filomena |
author_facet |
Gomes, Filomena Agustina, Rina Black, Robert E. Christian, Parul Dewey, Kathryn G. Kraemer, Klaus Shankar, Anuraj H. Smith, Emily Tumilowicz, Alison Bourassa, Megan W. |
author_role |
author |
author2 |
Agustina, Rina Black, Robert E. Christian, Parul Dewey, Kathryn G. Kraemer, Klaus Shankar, Anuraj H. Smith, Emily Tumilowicz, Alison Bourassa, Megan W. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Gomes, Filomena Agustina, Rina Black, Robert E. Christian, Parul Dewey, Kathryn G. Kraemer, Klaus Shankar, Anuraj H. Smith, Emily Tumilowicz, Alison Bourassa, Megan W. |
dc.subject.por.fl_str_mv |
iron Keywords: micronutrient supplements neonatal mortality pregnancy Medicine (miscellaneous) Nutrition and Dietetics Public Health, Environmental and Occupational Health SDG 3 - Good Health and Well-being |
topic |
iron Keywords: micronutrient supplements neonatal mortality pregnancy Medicine (miscellaneous) Nutrition and Dietetics Public Health, Environmental and Occupational Health SDG 3 - Good Health and Well-being |
description |
Publisher Copyright: © The Authors 2022. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-06-03T22:31:29Z 2022-08 2022-08-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/139413 |
url |
http://hdl.handle.net/10362/139413 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1368-9800 PURE: 44303511 https://doi.org/10.1017/S1368980022001008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799138093403471872 |