Depression and quality of life in patients with breast cancer undergoing chemotherapy and monoclonal antibodies
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/25780 https://doi.org/10.3332/ecancer.2019.937 |
Resumo: | Background: Depression is one of the major psychiatric morbidities in cancer patients. The purpose of our study was to evaluate the impact of depressive symptoms in the quality of life (QoL) of patients with breast cancer undergoing chemotherapy and monoclonal antibodies treatments. Methods: Observational, cross-sectional study conducted between April and November 2016. To evaluate the QoL, the EORTC QLQ-C30 and QLQ-BR23 questionnaire were used. The patients were screened for depressive symptoms using the Hospital Anxiety and Depression Scale (HADS-D) and those with a positive HADS-D positive questionnaire were referenced to the Psychiatry and Mental Health Department for further assessment and follow-up. Results: We included 45 female patients. Sixteen (35.6%) patients had a positive HADSD questionnaire and depressive symptoms confirmed by a psychiatric physician. Of those patients, 7 (15.6%) had a major depressive episode confirmed by psychiatric interview. There was a significant association of depressive symptoms with the future perspectives scale (p = 0.022), breast symptoms scale (p = 0.011) and arm symptom scale (p = 0.005). Significant differences were found in the fatigue (p = 0.024), pain (p = 0.037) and dyspnea (p = 0.009) subscales being worse in patients with depressive symptoms. The association between having depressive symptoms or not was shown to be significant or marginally significant for the variables stage of the tumour (p = 0.057), presence of distant metastasis (p = 0.072) and previous diagnosis of depression (p = 0.011). The patients treated with regimens containing monoclonal antibodies presented better outcomes in various subscales of the EORTC QLQ-C30 and QLQ-B23 questionnaires than those patients treated with chemotherapy regimens without monoclonal antibodies. Conclusions: Despite the small sample of our study, this study provided evidence that depressive symptoms in patients with breast cancer undergoing chemotherapy and monoclonal antibodies treatments detrimentally reduced various aspects of QoL |
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Depression and quality of life in patients with breast cancer undergoing chemotherapy and monoclonal antibodiesbreast neoplasmquality of lifedepressionchemotherapyantibodiesmonoclonalBackground: Depression is one of the major psychiatric morbidities in cancer patients. The purpose of our study was to evaluate the impact of depressive symptoms in the quality of life (QoL) of patients with breast cancer undergoing chemotherapy and monoclonal antibodies treatments. Methods: Observational, cross-sectional study conducted between April and November 2016. To evaluate the QoL, the EORTC QLQ-C30 and QLQ-BR23 questionnaire were used. The patients were screened for depressive symptoms using the Hospital Anxiety and Depression Scale (HADS-D) and those with a positive HADS-D positive questionnaire were referenced to the Psychiatry and Mental Health Department for further assessment and follow-up. Results: We included 45 female patients. Sixteen (35.6%) patients had a positive HADSD questionnaire and depressive symptoms confirmed by a psychiatric physician. Of those patients, 7 (15.6%) had a major depressive episode confirmed by psychiatric interview. There was a significant association of depressive symptoms with the future perspectives scale (p = 0.022), breast symptoms scale (p = 0.011) and arm symptom scale (p = 0.005). Significant differences were found in the fatigue (p = 0.024), pain (p = 0.037) and dyspnea (p = 0.009) subscales being worse in patients with depressive symptoms. The association between having depressive symptoms or not was shown to be significant or marginally significant for the variables stage of the tumour (p = 0.057), presence of distant metastasis (p = 0.072) and previous diagnosis of depression (p = 0.011). The patients treated with regimens containing monoclonal antibodies presented better outcomes in various subscales of the EORTC QLQ-C30 and QLQ-B23 questionnaires than those patients treated with chemotherapy regimens without monoclonal antibodies. Conclusions: Despite the small sample of our study, this study provided evidence that depressive symptoms in patients with breast cancer undergoing chemotherapy and monoclonal antibodies treatments detrimentally reduced various aspects of QoL2019-08-14T10:48:23Z2019-08-142019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/25780http://hdl.handle.net/10174/25780https://doi.org/10.3332/ecancer.2019.937porTrinca, F., Infante, P. Dinis, R. Inácio, M., Bravo, E., Caravana, J., Reis, T. Marques, S. (2019). Depression and quality of life in patients with breast cancer undergoing chemotherapy and monoclonal antibodies, ecancer 13:937, p. 1-20.1754-6605ecancermedicalscienceCIMAfrancisco_trinca@hotmail.compinfante@uevora.ptndndndndndsofiagracamarques@gmail.com233Trinca, FranciscoInfante, PauloDinis, RuiInácio, MarianaBravo, EmílioCaravana, JorgeReis, TeresaMarques, Sofiainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T19:19:56Zoai:dspace.uevora.pt:10174/25780Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:16:10.533898Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Depression and quality of life in patients with breast cancer undergoing chemotherapy and monoclonal antibodies |
title |
Depression and quality of life in patients with breast cancer undergoing chemotherapy and monoclonal antibodies |
spellingShingle |
Depression and quality of life in patients with breast cancer undergoing chemotherapy and monoclonal antibodies Trinca, Francisco breast neoplasm quality of life depression chemotherapy antibodies monoclonal |
title_short |
Depression and quality of life in patients with breast cancer undergoing chemotherapy and monoclonal antibodies |
title_full |
Depression and quality of life in patients with breast cancer undergoing chemotherapy and monoclonal antibodies |
title_fullStr |
Depression and quality of life in patients with breast cancer undergoing chemotherapy and monoclonal antibodies |
title_full_unstemmed |
Depression and quality of life in patients with breast cancer undergoing chemotherapy and monoclonal antibodies |
title_sort |
Depression and quality of life in patients with breast cancer undergoing chemotherapy and monoclonal antibodies |
author |
Trinca, Francisco |
author_facet |
Trinca, Francisco Infante, Paulo Dinis, Rui Inácio, Mariana Bravo, Emílio Caravana, Jorge Reis, Teresa Marques, Sofia |
author_role |
author |
author2 |
Infante, Paulo Dinis, Rui Inácio, Mariana Bravo, Emílio Caravana, Jorge Reis, Teresa Marques, Sofia |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Trinca, Francisco Infante, Paulo Dinis, Rui Inácio, Mariana Bravo, Emílio Caravana, Jorge Reis, Teresa Marques, Sofia |
dc.subject.por.fl_str_mv |
breast neoplasm quality of life depression chemotherapy antibodies monoclonal |
topic |
breast neoplasm quality of life depression chemotherapy antibodies monoclonal |
description |
Background: Depression is one of the major psychiatric morbidities in cancer patients. The purpose of our study was to evaluate the impact of depressive symptoms in the quality of life (QoL) of patients with breast cancer undergoing chemotherapy and monoclonal antibodies treatments. Methods: Observational, cross-sectional study conducted between April and November 2016. To evaluate the QoL, the EORTC QLQ-C30 and QLQ-BR23 questionnaire were used. The patients were screened for depressive symptoms using the Hospital Anxiety and Depression Scale (HADS-D) and those with a positive HADS-D positive questionnaire were referenced to the Psychiatry and Mental Health Department for further assessment and follow-up. Results: We included 45 female patients. Sixteen (35.6%) patients had a positive HADSD questionnaire and depressive symptoms confirmed by a psychiatric physician. Of those patients, 7 (15.6%) had a major depressive episode confirmed by psychiatric interview. There was a significant association of depressive symptoms with the future perspectives scale (p = 0.022), breast symptoms scale (p = 0.011) and arm symptom scale (p = 0.005). Significant differences were found in the fatigue (p = 0.024), pain (p = 0.037) and dyspnea (p = 0.009) subscales being worse in patients with depressive symptoms. The association between having depressive symptoms or not was shown to be significant or marginally significant for the variables stage of the tumour (p = 0.057), presence of distant metastasis (p = 0.072) and previous diagnosis of depression (p = 0.011). The patients treated with regimens containing monoclonal antibodies presented better outcomes in various subscales of the EORTC QLQ-C30 and QLQ-B23 questionnaires than those patients treated with chemotherapy regimens without monoclonal antibodies. Conclusions: Despite the small sample of our study, this study provided evidence that depressive symptoms in patients with breast cancer undergoing chemotherapy and monoclonal antibodies treatments detrimentally reduced various aspects of QoL |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-08-14T10:48:23Z 2019-08-14 2019-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/25780 http://hdl.handle.net/10174/25780 https://doi.org/10.3332/ecancer.2019.937 |
url |
http://hdl.handle.net/10174/25780 https://doi.org/10.3332/ecancer.2019.937 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Trinca, F., Infante, P. Dinis, R. Inácio, M., Bravo, E., Caravana, J., Reis, T. Marques, S. (2019). Depression and quality of life in patients with breast cancer undergoing chemotherapy and monoclonal antibodies, ecancer 13:937, p. 1-20. 1754-6605 ecancermedicalscience CIMA francisco_trinca@hotmail.com pinfante@uevora.pt nd nd nd nd nd sofiagracamarques@gmail.com 233 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136643487105024 |