Intra-articular injection of culture-expanded mesenchymal stem cells with or without addition of platelet-rich plasma is effective in decreasing pain and symptoms in knee osteoarthritis: a controlled, double-blind clinical trial

Detalhes bibliográficos
Autor(a) principal: Bastos, Ricardo
Data de Publicação: 2020
Outros Autores: Mathias, Marcelo, Andrade, Renato, Amaral, Ronaldo J. F. C., Schott, Vinicius, Balduino, Alex, Bastos, Raquel, Oliveira, Joaquim M., Reis, R. L., Rodeo, Scott, Espregueira-Mendes, João
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/62147
Resumo: [Epub ahead of print]
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spelling Intra-articular injection of culture-expanded mesenchymal stem cells with or without addition of platelet-rich plasma is effective in decreasing pain and symptoms in knee osteoarthritis: a controlled, double-blind clinical trialOsteoarthritisMesenchymal stem cellsIntra-articular injectionPlatelet-rich plasmaScience & Technology[Epub ahead of print]PURPOSE:To compare the clinical and laboratory outcomes of intra-articular injections of culture-expanded bone-derived mesenchymal stem cells (MSCs) with or without platelet-rich plasma (PRP) to intra-articular corticosteroid injections for the treatment of knee osteoarthritis (OA). METHODS:Forty-seven patients with radiographic and symptomatic knee OA were randomized into three groups for intra-articular injections: autologous bone marrow-derived culture-expanded MSCs (nâ =â 16); autologous bone marrow-derived culture-expanded MSCsâ +â PRP (nâ =â 14); and corticosteroid (nâ =â 17). The outcomes were assessed by the Knee Injury and Osteoarthritis Outcome Score (KOOS) and range of motion (ROM) at baseline, 1, 2, 3, 6, 9 and 12 months and intra-articular cytokines analysis at baseline, 6 and 12 months postoperatively. RESULTS:The three groups showed significant improvement in most KOOS domains and global score at 1st month and all domains and global score at 12-month follow-up (pâ <â 0.05). At the 1st month, only the MSCs group showed significant differences in KOOS symptoms domain (pâ =â 0.003). The MSCs and MSCsâ +â PRP groups showed the highest percentage of improvement in most KOOS domains and global score compared to the corticosteroid group. All three groups showed a significant reduction in intra-articular levels of human interleukin-10 cytokine, from baseline to 12 months (pâ <â 0.05). CONCLUSION:An intra-articular injection of bone marrow-derived culture-expanded MSCs with or without the addiction of PRP is effective in improving the function and decreasing symptoms caused by knee OA at 12-month follow-up. LEVEL OF EVIDENCE:II.SpringerUniversidade do MinhoBastos, RicardoMathias, MarceloAndrade, RenatoAmaral, Ronaldo J. F. C.Schott, ViniciusBalduino, AlexBastos, RaquelOliveira, Joaquim M.Reis, R. L.Rodeo, ScottEspregueira-Mendes, João20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/62147engBastos R., Mathias M., Andrade R., Bastos R., Balduino A., Schott B., Amaral R. J. F. C., Oliveira J. M., Reis R. L., Rodeo S., Espregueira-Mendes J. Intra-articular injection of culture-expanded mesenchymal stem cells with or without addition of platelet-rich plasma is effective in decreasing pain and symptoms in knee osteoarthritis: a controlled, double-blind clinical trial, Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA, pp. 1-11, doi:10.1007/s00167-019-05732-8, 2020.0942-20561433-734710.1007/s00167-019-05732-83158709110.1007/s00167-019-05732-8info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:58:27Zoai:repositorium.sdum.uminho.pt:1822/62147Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:48:09.830947Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Intra-articular injection of culture-expanded mesenchymal stem cells with or without addition of platelet-rich plasma is effective in decreasing pain and symptoms in knee osteoarthritis: a controlled, double-blind clinical trial
title Intra-articular injection of culture-expanded mesenchymal stem cells with or without addition of platelet-rich plasma is effective in decreasing pain and symptoms in knee osteoarthritis: a controlled, double-blind clinical trial
spellingShingle Intra-articular injection of culture-expanded mesenchymal stem cells with or without addition of platelet-rich plasma is effective in decreasing pain and symptoms in knee osteoarthritis: a controlled, double-blind clinical trial
Bastos, Ricardo
Osteoarthritis
Mesenchymal stem cells
Intra-articular injection
Platelet-rich plasma
Science & Technology
title_short Intra-articular injection of culture-expanded mesenchymal stem cells with or without addition of platelet-rich plasma is effective in decreasing pain and symptoms in knee osteoarthritis: a controlled, double-blind clinical trial
title_full Intra-articular injection of culture-expanded mesenchymal stem cells with or without addition of platelet-rich plasma is effective in decreasing pain and symptoms in knee osteoarthritis: a controlled, double-blind clinical trial
title_fullStr Intra-articular injection of culture-expanded mesenchymal stem cells with or without addition of platelet-rich plasma is effective in decreasing pain and symptoms in knee osteoarthritis: a controlled, double-blind clinical trial
title_full_unstemmed Intra-articular injection of culture-expanded mesenchymal stem cells with or without addition of platelet-rich plasma is effective in decreasing pain and symptoms in knee osteoarthritis: a controlled, double-blind clinical trial
title_sort Intra-articular injection of culture-expanded mesenchymal stem cells with or without addition of platelet-rich plasma is effective in decreasing pain and symptoms in knee osteoarthritis: a controlled, double-blind clinical trial
author Bastos, Ricardo
author_facet Bastos, Ricardo
Mathias, Marcelo
Andrade, Renato
Amaral, Ronaldo J. F. C.
Schott, Vinicius
Balduino, Alex
Bastos, Raquel
Oliveira, Joaquim M.
Reis, R. L.
Rodeo, Scott
Espregueira-Mendes, João
author_role author
author2 Mathias, Marcelo
Andrade, Renato
Amaral, Ronaldo J. F. C.
Schott, Vinicius
Balduino, Alex
Bastos, Raquel
Oliveira, Joaquim M.
Reis, R. L.
Rodeo, Scott
Espregueira-Mendes, João
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Bastos, Ricardo
Mathias, Marcelo
Andrade, Renato
Amaral, Ronaldo J. F. C.
Schott, Vinicius
Balduino, Alex
Bastos, Raquel
Oliveira, Joaquim M.
Reis, R. L.
Rodeo, Scott
Espregueira-Mendes, João
dc.subject.por.fl_str_mv Osteoarthritis
Mesenchymal stem cells
Intra-articular injection
Platelet-rich plasma
Science & Technology
topic Osteoarthritis
Mesenchymal stem cells
Intra-articular injection
Platelet-rich plasma
Science & Technology
description [Epub ahead of print]
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/62147
url http://hdl.handle.net/1822/62147
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Bastos R., Mathias M., Andrade R., Bastos R., Balduino A., Schott B., Amaral R. J. F. C., Oliveira J. M., Reis R. L., Rodeo S., Espregueira-Mendes J. Intra-articular injection of culture-expanded mesenchymal stem cells with or without addition of platelet-rich plasma is effective in decreasing pain and symptoms in knee osteoarthritis: a controlled, double-blind clinical trial, Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA, pp. 1-11, doi:10.1007/s00167-019-05732-8, 2020.
0942-2056
1433-7347
10.1007/s00167-019-05732-8
31587091
10.1007/s00167-019-05732-8
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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