Mesenchymal stem cells relevance in multicellular bioengineered 3D In vitro tumor models

Detalhes bibliográficos
Autor(a) principal: Ferreira, Luís P.
Data de Publicação: 2017
Outros Autores: Gaspar, Vítor M., Henrique, Rui, Jerónimo, Carmen, Mano, João F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/25677
Resumo: In vitro 3D tumor microenvironment mimicking models are gathering momentum as alternatives to traditional 2D flat monolayer cultures due to their potential for recapitulating major cancer hallmarks. To fulfill such potential, it is crucial that 3D tumor testing platforms completely emulate in vitro the complex in vivo tumor niche and its cellular constituents. Mesenchymal stem cells (MSCs) are recognized to play a pivotal multi-modulatory role in cancer, generating interest as biological targets and as key tumor suppressing, or tumor promoting effectors. This review discusses the biological influence of different types of MSCs in the tumor microenvironment and showcases recent studies that engineer 3D MSCs-cancer cells co-cultures as advanced in vitro therapy testing platforms. A special focus is given to MSCs-cancer 3D co-culture set-up parameters, challenges, and future opportunities. Understanding cancer-MSCs crosstalk and their underlying effects is envisioned to support the development of advanced 3D in vitro disease models for discovery of forefront cancer treatments.
id RCAP_16fe5b6031aed08745595d78c0a7bdbc
oai_identifier_str oai:ria.ua.pt:10773/25677
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Mesenchymal stem cells relevance in multicellular bioengineered 3D In vitro tumor models3D modelsCo-cultureDrug testingIn vitro tumorsIn vitro 3D tumor microenvironment mimicking models are gathering momentum as alternatives to traditional 2D flat monolayer cultures due to their potential for recapitulating major cancer hallmarks. To fulfill such potential, it is crucial that 3D tumor testing platforms completely emulate in vitro the complex in vivo tumor niche and its cellular constituents. Mesenchymal stem cells (MSCs) are recognized to play a pivotal multi-modulatory role in cancer, generating interest as biological targets and as key tumor suppressing, or tumor promoting effectors. This review discusses the biological influence of different types of MSCs in the tumor microenvironment and showcases recent studies that engineer 3D MSCs-cancer cells co-cultures as advanced in vitro therapy testing platforms. A special focus is given to MSCs-cancer 3D co-culture set-up parameters, challenges, and future opportunities. Understanding cancer-MSCs crosstalk and their underlying effects is envisioned to support the development of advanced 3D in vitro disease models for discovery of forefront cancer treatments.Wiley2019-03-29T12:10:41Z2017-12-01T00:00:00Z2017-12info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/vnd.openxmlformats-officedocument.wordprocessingml.documenthttp://hdl.handle.net/10773/25677eng1860-676810.1002/biot.201700079Ferreira, Luís P.Gaspar, Vítor M.Henrique, RuiJerónimo, CarmenMano, João F.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:49:47Zoai:ria.ua.pt:10773/25677Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:58:51.405868Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Mesenchymal stem cells relevance in multicellular bioengineered 3D In vitro tumor models
title Mesenchymal stem cells relevance in multicellular bioengineered 3D In vitro tumor models
spellingShingle Mesenchymal stem cells relevance in multicellular bioengineered 3D In vitro tumor models
Ferreira, Luís P.
3D models
Co-culture
Drug testing
In vitro tumors
title_short Mesenchymal stem cells relevance in multicellular bioengineered 3D In vitro tumor models
title_full Mesenchymal stem cells relevance in multicellular bioengineered 3D In vitro tumor models
title_fullStr Mesenchymal stem cells relevance in multicellular bioengineered 3D In vitro tumor models
title_full_unstemmed Mesenchymal stem cells relevance in multicellular bioengineered 3D In vitro tumor models
title_sort Mesenchymal stem cells relevance in multicellular bioengineered 3D In vitro tumor models
author Ferreira, Luís P.
author_facet Ferreira, Luís P.
Gaspar, Vítor M.
Henrique, Rui
Jerónimo, Carmen
Mano, João F.
author_role author
author2 Gaspar, Vítor M.
Henrique, Rui
Jerónimo, Carmen
Mano, João F.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Ferreira, Luís P.
Gaspar, Vítor M.
Henrique, Rui
Jerónimo, Carmen
Mano, João F.
dc.subject.por.fl_str_mv 3D models
Co-culture
Drug testing
In vitro tumors
topic 3D models
Co-culture
Drug testing
In vitro tumors
description In vitro 3D tumor microenvironment mimicking models are gathering momentum as alternatives to traditional 2D flat monolayer cultures due to their potential for recapitulating major cancer hallmarks. To fulfill such potential, it is crucial that 3D tumor testing platforms completely emulate in vitro the complex in vivo tumor niche and its cellular constituents. Mesenchymal stem cells (MSCs) are recognized to play a pivotal multi-modulatory role in cancer, generating interest as biological targets and as key tumor suppressing, or tumor promoting effectors. This review discusses the biological influence of different types of MSCs in the tumor microenvironment and showcases recent studies that engineer 3D MSCs-cancer cells co-cultures as advanced in vitro therapy testing platforms. A special focus is given to MSCs-cancer 3D co-culture set-up parameters, challenges, and future opportunities. Understanding cancer-MSCs crosstalk and their underlying effects is envisioned to support the development of advanced 3D in vitro disease models for discovery of forefront cancer treatments.
publishDate 2017
dc.date.none.fl_str_mv 2017-12-01T00:00:00Z
2017-12
2019-03-29T12:10:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/25677
url http://hdl.handle.net/10773/25677
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1860-6768
10.1002/biot.201700079
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/vnd.openxmlformats-officedocument.wordprocessingml.document
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799137642584997888

Registros relacionados