3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs

Detalhes bibliográficos
Autor(a) principal: Nunes, Ana S.
Data de Publicação: 2019
Outros Autores: Barros, Andreia, Costa, Elisabete, Moreira, André, Correia, I.J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/6896
Resumo: Three-dimensional cell culture models, such as spheroids, can be used in the process of the development of new anticancer agents because they are able to closely mimic the main features of human solid tumors, namely their structural organization, cellular layered assembling, hypoxia, and nutrient gradients. These properties imprint to the spheroids an anticancer therapeutics resistance profile, which is similar to that displayed by human solid tumors. In this review, an overview of the drug resistance mechanisms observed in 3D tumor spheroids is provided. Furthermore, comparisons between the therapeutics resistance profile exhibited by spheroids, and 2D cell cultures are presented. Finally, examples of the therapeutic approaches that have been developed to surpass the drug resistance mechanisms exhibited by spheroids are described.
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spelling 3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugsDrug resistanceDrugsIn vitro modelsSolid tumorsSpheroidsThree-dimensional cell culture models, such as spheroids, can be used in the process of the development of new anticancer agents because they are able to closely mimic the main features of human solid tumors, namely their structural organization, cellular layered assembling, hypoxia, and nutrient gradients. These properties imprint to the spheroids an anticancer therapeutics resistance profile, which is similar to that displayed by human solid tumors. In this review, an overview of the drug resistance mechanisms observed in 3D tumor spheroids is provided. Furthermore, comparisons between the therapeutics resistance profile exhibited by spheroids, and 2D cell cultures are presented. Finally, examples of the therapeutic approaches that have been developed to surpass the drug resistance mechanisms exhibited by spheroids are described.WileyuBibliorumNunes, Ana S.Barros, AndreiaCosta, ElisabeteMoreira, AndréCorreia, I.J.2022-03-08T01:30:16Z2019-01-212019-01-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/6896eng10.1002/bit.26845info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-15T09:45:53Zoai:ubibliorum.ubi.pt:10400.6/6896Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:47:32.295804Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv 3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs
title 3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs
spellingShingle 3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs
Nunes, Ana S.
Drug resistance
Drugs
In vitro models
Solid tumors
Spheroids
title_short 3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs
title_full 3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs
title_fullStr 3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs
title_full_unstemmed 3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs
title_sort 3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs
author Nunes, Ana S.
author_facet Nunes, Ana S.
Barros, Andreia
Costa, Elisabete
Moreira, André
Correia, I.J.
author_role author
author2 Barros, Andreia
Costa, Elisabete
Moreira, André
Correia, I.J.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Nunes, Ana S.
Barros, Andreia
Costa, Elisabete
Moreira, André
Correia, I.J.
dc.subject.por.fl_str_mv Drug resistance
Drugs
In vitro models
Solid tumors
Spheroids
topic Drug resistance
Drugs
In vitro models
Solid tumors
Spheroids
description Three-dimensional cell culture models, such as spheroids, can be used in the process of the development of new anticancer agents because they are able to closely mimic the main features of human solid tumors, namely their structural organization, cellular layered assembling, hypoxia, and nutrient gradients. These properties imprint to the spheroids an anticancer therapeutics resistance profile, which is similar to that displayed by human solid tumors. In this review, an overview of the drug resistance mechanisms observed in 3D tumor spheroids is provided. Furthermore, comparisons between the therapeutics resistance profile exhibited by spheroids, and 2D cell cultures are presented. Finally, examples of the therapeutic approaches that have been developed to surpass the drug resistance mechanisms exhibited by spheroids are described.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-21
2019-01-21T00:00:00Z
2022-03-08T01:30:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/6896
url http://hdl.handle.net/10400.6/6896
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1002/bit.26845
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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