Congenital anomalies in children with postneonatally acquired cerebral palsy: an international data linkage study

Detalhes bibliográficos
Autor(a) principal: Goldsmith, Shona
Data de Publicação: 2021
Outros Autores: McIntyre, Sarah, Scott, Heather, Himmelmann, Kate, Smithers‐Sheedy, Hayley, Andersen, Guro L., Blair, Eve, Badawi, Nadia, Garne, Ester, Comprehensive CA-CP Study Group
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/7914
Resumo: Comprehensive CA-CP Study Group: Ingeborg Barisic, Vlatka Bosnjak Mejaski, Emmanuelle Amar, Elodie Sellier, Sandra Julsen Hollung, Kari Klungsøyr, Paula Braz, Daniel Virella, Catherine Gibson, Karin Källén, Susan M Reid, Gareth Baynam, Dylan Gration, Michèle Hansen, Linda Watson
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spelling Congenital anomalies in children with postneonatally acquired cerebral palsy: an international data linkage studyAnomalías congénitas en ninos con parálisis cerebral adquirida postnatal: un estudio combinando de registros internacionalesCerebral PalsyCongenital AnomaliesData LinkageEUROCATEuropean Surveillance of Congenital AnomaliesPVNPCEstados de Saúde e de DoençaObservação em Saúde e VigilânciaRENACEuropeRegisto Nacional de Anomalias CongénitasPortugalComprehensive CA-CP Study Group: Ingeborg Barisic, Vlatka Bosnjak Mejaski, Emmanuelle Amar, Elodie Sellier, Sandra Julsen Hollung, Kari Klungsøyr, Paula Braz, Daniel Virella, Catherine Gibson, Karin Källén, Susan M Reid, Gareth Baynam, Dylan Gration, Michèle Hansen, Linda WatsonComprehensive CA-CP Study Group: Paula Braz, Daniel Virella. INSA, Portugal.Aim: To describe the major congenital anomalies present in children with postneonatally acquired cerebral palsy (CP), and to compare clinical outcomes and cause of postneonatally acquired CP between children with and without anomalies. Method: Data were linked between total population CP and congenital anomaly registers in five European and three Australian regions for children born 1991 to 2009 (n=468 children with postneonatally acquired CP; 255 males, 213 females). Data were pooled and children classified into mutually exclusive categories based on type of congenital anomaly. The proportion of children with congenital anomalies was calculated. Clinical outcomes and cause of postneonatally acquired CP were compared between children with and without anomalies. Results: Major congenital anomalies were reported in 25.6% (95% confidence interval [CI] 21.7-29.9) of children with postneonatally acquired CP. Cardiac anomalies, often severe, were common and present in 14.5% of children with postneonatally acquired CP. Clinical outcomes were not more severe in children with congenital anomalies than those without anomalies. Cause of postneonatally acquired CP differed with the presence of congenital anomalies, with cerebrovascular accidents predominating in the anomaly group. Congenital anomalies were likely associated with cause of postneonatally acquired CP in 77% of children with anomalies. Interpretation: In this large, international study of children with postneonatally acquired CP, congenital anomalies (particularly cardiac anomalies) were common. Future research should determine specific causal pathways to postneonatally acquired CP that include congenital anomalies to identify opportunities for prevention. What this paper adds: One-quarter of children with postneonatally acquired cerebral palsy (CP) have a major congenital anomaly. Cardiac anomalies, often severe, are the most common anomalies. Causes of postneonatally acquired CP differ between children with and without congenital anomalies.Objetivo: Describir las principales anomalías congenitas presentes en niños con parálisis cerebral (PC) adquirida posnatalmente y comparar los resultados clínicos y la causa de PC entre niños con y sin anomalías. Método: Se relacionaron los registros de datos de la población con PC y los registros de anomalías congenitas de cinco regiones de Europa y tres de Australia de niños nacidos de 1991 a 2009 (n = 468 niños con PC adquirida posnatalmente; 255 varones, 213 mujeres). Se agruparon los datos y clasificaron en categor ıas mutuamente excluyentes segun el tipo de anomalías congenita. Se calcul o la pro-porcion de ni nos con anomalías congenitas. Se compararon los resultados clínicos y la causa de la PC adquirida posnatalmente entre niños con y sin anomalías. Resultados: Se registraron anomalías congenitas importantes en el 25,6% (intervalo de confianza [IC] del 95%: 21,7-29,9) de los niños con PC adquirida despues del nacimiento. Hubo una alta frecuencia de anomalías cardíacas, que estaban presentes en el 14,5% de los niños con PC adquirida posnatalmente. La evolución clínica no fue diferentes entre niños con o sin anomalías congenitas. La causa de PC adquirida posnatalmente vario con la presencia de anomalías congenitas, predominando los accidentes cerebrovasculares en el grupo de anomalías congenitas. La causa de PC adquirida posnatalmente esta probablemente asociada con anomalias congenitas en el 77% de los niños con anomalías. Interpretacion: En este estudio internacional de niños con PC adquirida posnatalmente, las anomalías congenitas fueron frecuentes, particularmente las anomalías cardíacas. Las investigaciones futuras deben determinar las vías causales específicas de la PC adquirida posnatalmente que incluyen anomalías congenitas para identificar oportunidades de prevención.Wiley/ Mac Keith PressRepositório Científico do Instituto Nacional de SaúdeGoldsmith, ShonaMcIntyre, SarahScott, HeatherHimmelmann, KateSmithers‐Sheedy, HayleyAndersen, Guro L.Blair, EveBadawi, NadiaGarne, EsterComprehensive CA-CP Study Group2022-02-02T16:33:25Z2021-01-112021-01-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/7914engDev Med Child Neurol. 2021 Apr;63(4):421-428. doi: 10.1111/dmcn.14805. Epub 2021 Jan 110012-162210.1111/dmcn.14805info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:15Zoai:repositorio.insa.pt:10400.18/7914Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:42:30.548037Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Congenital anomalies in children with postneonatally acquired cerebral palsy: an international data linkage study
Anomalías congénitas en ninos con parálisis cerebral adquirida postnatal: un estudio combinando de registros internacionales
title Congenital anomalies in children with postneonatally acquired cerebral palsy: an international data linkage study
spellingShingle Congenital anomalies in children with postneonatally acquired cerebral palsy: an international data linkage study
Goldsmith, Shona
Cerebral Palsy
Congenital Anomalies
Data Linkage
EUROCAT
European Surveillance of Congenital Anomalies
PVNPC
Estados de Saúde e de Doença
Observação em Saúde e Vigilância
RENAC
Europe
Registo Nacional de Anomalias Congénitas
Portugal
title_short Congenital anomalies in children with postneonatally acquired cerebral palsy: an international data linkage study
title_full Congenital anomalies in children with postneonatally acquired cerebral palsy: an international data linkage study
title_fullStr Congenital anomalies in children with postneonatally acquired cerebral palsy: an international data linkage study
title_full_unstemmed Congenital anomalies in children with postneonatally acquired cerebral palsy: an international data linkage study
title_sort Congenital anomalies in children with postneonatally acquired cerebral palsy: an international data linkage study
author Goldsmith, Shona
author_facet Goldsmith, Shona
McIntyre, Sarah
Scott, Heather
Himmelmann, Kate
Smithers‐Sheedy, Hayley
Andersen, Guro L.
Blair, Eve
Badawi, Nadia
Garne, Ester
Comprehensive CA-CP Study Group
author_role author
author2 McIntyre, Sarah
Scott, Heather
Himmelmann, Kate
Smithers‐Sheedy, Hayley
Andersen, Guro L.
Blair, Eve
Badawi, Nadia
Garne, Ester
Comprehensive CA-CP Study Group
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Goldsmith, Shona
McIntyre, Sarah
Scott, Heather
Himmelmann, Kate
Smithers‐Sheedy, Hayley
Andersen, Guro L.
Blair, Eve
Badawi, Nadia
Garne, Ester
Comprehensive CA-CP Study Group
dc.subject.por.fl_str_mv Cerebral Palsy
Congenital Anomalies
Data Linkage
EUROCAT
European Surveillance of Congenital Anomalies
PVNPC
Estados de Saúde e de Doença
Observação em Saúde e Vigilância
RENAC
Europe
Registo Nacional de Anomalias Congénitas
Portugal
topic Cerebral Palsy
Congenital Anomalies
Data Linkage
EUROCAT
European Surveillance of Congenital Anomalies
PVNPC
Estados de Saúde e de Doença
Observação em Saúde e Vigilância
RENAC
Europe
Registo Nacional de Anomalias Congénitas
Portugal
description Comprehensive CA-CP Study Group: Ingeborg Barisic, Vlatka Bosnjak Mejaski, Emmanuelle Amar, Elodie Sellier, Sandra Julsen Hollung, Kari Klungsøyr, Paula Braz, Daniel Virella, Catherine Gibson, Karin Källén, Susan M Reid, Gareth Baynam, Dylan Gration, Michèle Hansen, Linda Watson
publishDate 2021
dc.date.none.fl_str_mv 2021-01-11
2021-01-11T00:00:00Z
2022-02-02T16:33:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/7914
url http://hdl.handle.net/10400.18/7914
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Dev Med Child Neurol. 2021 Apr;63(4):421-428. doi: 10.1111/dmcn.14805. Epub 2021 Jan 11
0012-1622
10.1111/dmcn.14805
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley/ Mac Keith Press
publisher.none.fl_str_mv Wiley/ Mac Keith Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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