Congenital anomalies in children with pre‐ or perinatally acquired cerebral palsy: an international data linkage study

Detalhes bibliográficos
Autor(a) principal: Goldsmith, Shona
Data de Publicação: 2020
Outros Autores: Mcintyre, Sarah, Andersen, Guro L, Gibson, Catherine, Himmelmann, Kate, Blair, Eve, Badawi, Nadia, Smithers‐Sheedy, Hayley, Garne, Ester, Comprehensive CA-CP Study Group
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/7349
Resumo: Members of the Comprehensive CA-CP study group: Paula Braz and Daniel Virella, Portugal. Departamento de Epidemiologia do INSA
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spelling Congenital anomalies in children with pre‐ or perinatally acquired cerebral palsy: an international data linkage studyCongenital AnomaliesChildrenEuropean Surveillance of Congenital AnomaliesEUROCATAnomalias CongénitasParalisia CerebralEstados de Saúde e de DoençaRegistos EpidemiológicosRegisto Nacional de Anomalias CongénitasRENACPrograma Nacional de Vigilância da Paralisia CerebralPNVPCEuropePortugalMembers of the Comprehensive CA-CP study group: Paula Braz and Daniel Virella, Portugal. Departamento de Epidemiologia do INSAAim: To describe the frequency and types of major congenital anomalies present in children with pre- or perinatally acquired cerebral palsy (CP), and compare clinical outcomes for children with and without anomalies. Method: This multi-centre total population collaborative study between Surveillance of Cerebral Palsy in Europe, Australian Cerebral Palsy Register, and European Surveillance of Congenital Anomalies (EUROCAT) involved six European and three Australian regions. Data were linked between each region's CP and congenital anomaly register for children born between 1991 and 2009, and then pooled. Children were classified into mutually exclusive categories based on type of anomaly. Proportions of children with congenital anomalies were calculated, and clinical outcomes compared between children with and without anomalies. Results: Of 8201 children with CP, 22.8% (95% confidence interval [CI] 21.9, 23.8) had a major congenital anomaly. Isolated cerebral anomalies were most common (45.2%), with a further 8.6% having both cerebral and non-cerebral anomalies. Cardiac anomalies only were described in 10.5% of children and anomalies associated with syndromes were also reported: genetic (8.0%), chromosomal (5.7%), and teratogenic (3.0%). Clinical outcomes were more severe for children with CP and congenital anomalies, particularly cerebral anomalies. Interpretation: This large, international study reports major congenital anomalies in nearly one-quarter of children with pre- or perinatally acquired CP. Future research must focus on aetiological pathways to CP that include specific patterns of congenital anomalies. What this paper adds: Congenital anomalies were reported in 23% of children with pre- or perinatally acquired cerebral palsy. A higher proportion of children born at or near term had anomalies. The most common type of anomalies were isolated cerebral anomalies. Clinical outcomes were more severe for children with congenital anomalies (particularly cerebral).Cerebral Palsy Alliance Research Foundation. Grant Numbers: PG1215, PG2816, Salary support (SG, SM, HSS, NB)Wiley/ Mac Keith PressRepositório Científico do Instituto Nacional de SaúdeGoldsmith, ShonaMcintyre, SarahAndersen, Guro LGibson, CatherineHimmelmann, KateBlair, EveBadawi, NadiaSmithers‐Sheedy, HayleyGarne, EsterComprehensive CA-CP Study Group2021-03-06T16:18:13Z2020-06-242020-06-24T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/7349engDev Med Child Neurol. 2021 Apr;63(4):413-420. doi: 10.1111/dmcn.14602. Epub 2020 Jun 24.0012-162210.1111/dmcn.14602info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:54Zoai:repositorio.insa.pt:10400.18/7349Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:41:56.196117Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Congenital anomalies in children with pre‐ or perinatally acquired cerebral palsy: an international data linkage study
title Congenital anomalies in children with pre‐ or perinatally acquired cerebral palsy: an international data linkage study
spellingShingle Congenital anomalies in children with pre‐ or perinatally acquired cerebral palsy: an international data linkage study
Goldsmith, Shona
Congenital Anomalies
Children
European Surveillance of Congenital Anomalies
EUROCAT
Anomalias Congénitas
Paralisia Cerebral
Estados de Saúde e de Doença
Registos Epidemiológicos
Registo Nacional de Anomalias Congénitas
RENAC
Programa Nacional de Vigilância da Paralisia Cerebral
PNVPC
Europe
Portugal
title_short Congenital anomalies in children with pre‐ or perinatally acquired cerebral palsy: an international data linkage study
title_full Congenital anomalies in children with pre‐ or perinatally acquired cerebral palsy: an international data linkage study
title_fullStr Congenital anomalies in children with pre‐ or perinatally acquired cerebral palsy: an international data linkage study
title_full_unstemmed Congenital anomalies in children with pre‐ or perinatally acquired cerebral palsy: an international data linkage study
title_sort Congenital anomalies in children with pre‐ or perinatally acquired cerebral palsy: an international data linkage study
author Goldsmith, Shona
author_facet Goldsmith, Shona
Mcintyre, Sarah
Andersen, Guro L
Gibson, Catherine
Himmelmann, Kate
Blair, Eve
Badawi, Nadia
Smithers‐Sheedy, Hayley
Garne, Ester
Comprehensive CA-CP Study Group
author_role author
author2 Mcintyre, Sarah
Andersen, Guro L
Gibson, Catherine
Himmelmann, Kate
Blair, Eve
Badawi, Nadia
Smithers‐Sheedy, Hayley
Garne, Ester
Comprehensive CA-CP Study Group
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Goldsmith, Shona
Mcintyre, Sarah
Andersen, Guro L
Gibson, Catherine
Himmelmann, Kate
Blair, Eve
Badawi, Nadia
Smithers‐Sheedy, Hayley
Garne, Ester
Comprehensive CA-CP Study Group
dc.subject.por.fl_str_mv Congenital Anomalies
Children
European Surveillance of Congenital Anomalies
EUROCAT
Anomalias Congénitas
Paralisia Cerebral
Estados de Saúde e de Doença
Registos Epidemiológicos
Registo Nacional de Anomalias Congénitas
RENAC
Programa Nacional de Vigilância da Paralisia Cerebral
PNVPC
Europe
Portugal
topic Congenital Anomalies
Children
European Surveillance of Congenital Anomalies
EUROCAT
Anomalias Congénitas
Paralisia Cerebral
Estados de Saúde e de Doença
Registos Epidemiológicos
Registo Nacional de Anomalias Congénitas
RENAC
Programa Nacional de Vigilância da Paralisia Cerebral
PNVPC
Europe
Portugal
description Members of the Comprehensive CA-CP study group: Paula Braz and Daniel Virella, Portugal. Departamento de Epidemiologia do INSA
publishDate 2020
dc.date.none.fl_str_mv 2020-06-24
2020-06-24T00:00:00Z
2021-03-06T16:18:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/7349
url http://hdl.handle.net/10400.18/7349
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Dev Med Child Neurol. 2021 Apr;63(4):413-420. doi: 10.1111/dmcn.14602. Epub 2020 Jun 24.
0012-1622
10.1111/dmcn.14602
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
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dc.publisher.none.fl_str_mv Wiley/ Mac Keith Press
publisher.none.fl_str_mv Wiley/ Mac Keith Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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