Congenital anomalies in children with pre‐ or perinatally acquired cerebral palsy: an international data linkage study
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/7349 |
Resumo: | Members of the Comprehensive CA-CP study group: Paula Braz and Daniel Virella, Portugal. Departamento de Epidemiologia do INSA |
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7160 |
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Congenital anomalies in children with pre‐ or perinatally acquired cerebral palsy: an international data linkage studyCongenital AnomaliesChildrenEuropean Surveillance of Congenital AnomaliesEUROCATAnomalias CongénitasParalisia CerebralEstados de Saúde e de DoençaRegistos EpidemiológicosRegisto Nacional de Anomalias CongénitasRENACPrograma Nacional de Vigilância da Paralisia CerebralPNVPCEuropePortugalMembers of the Comprehensive CA-CP study group: Paula Braz and Daniel Virella, Portugal. Departamento de Epidemiologia do INSAAim: To describe the frequency and types of major congenital anomalies present in children with pre- or perinatally acquired cerebral palsy (CP), and compare clinical outcomes for children with and without anomalies. Method: This multi-centre total population collaborative study between Surveillance of Cerebral Palsy in Europe, Australian Cerebral Palsy Register, and European Surveillance of Congenital Anomalies (EUROCAT) involved six European and three Australian regions. Data were linked between each region's CP and congenital anomaly register for children born between 1991 and 2009, and then pooled. Children were classified into mutually exclusive categories based on type of anomaly. Proportions of children with congenital anomalies were calculated, and clinical outcomes compared between children with and without anomalies. Results: Of 8201 children with CP, 22.8% (95% confidence interval [CI] 21.9, 23.8) had a major congenital anomaly. Isolated cerebral anomalies were most common (45.2%), with a further 8.6% having both cerebral and non-cerebral anomalies. Cardiac anomalies only were described in 10.5% of children and anomalies associated with syndromes were also reported: genetic (8.0%), chromosomal (5.7%), and teratogenic (3.0%). Clinical outcomes were more severe for children with CP and congenital anomalies, particularly cerebral anomalies. Interpretation: This large, international study reports major congenital anomalies in nearly one-quarter of children with pre- or perinatally acquired CP. Future research must focus on aetiological pathways to CP that include specific patterns of congenital anomalies. What this paper adds: Congenital anomalies were reported in 23% of children with pre- or perinatally acquired cerebral palsy. A higher proportion of children born at or near term had anomalies. The most common type of anomalies were isolated cerebral anomalies. Clinical outcomes were more severe for children with congenital anomalies (particularly cerebral).Cerebral Palsy Alliance Research Foundation. Grant Numbers: PG1215, PG2816, Salary support (SG, SM, HSS, NB)Wiley/ Mac Keith PressRepositório Científico do Instituto Nacional de SaúdeGoldsmith, ShonaMcintyre, SarahAndersen, Guro LGibson, CatherineHimmelmann, KateBlair, EveBadawi, NadiaSmithers‐Sheedy, HayleyGarne, EsterComprehensive CA-CP Study Group2021-03-06T16:18:13Z2020-06-242020-06-24T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/7349engDev Med Child Neurol. 2021 Apr;63(4):413-420. doi: 10.1111/dmcn.14602. Epub 2020 Jun 24.0012-162210.1111/dmcn.14602info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:54Zoai:repositorio.insa.pt:10400.18/7349Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:41:56.196117Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Congenital anomalies in children with pre‐ or perinatally acquired cerebral palsy: an international data linkage study |
title |
Congenital anomalies in children with pre‐ or perinatally acquired cerebral palsy: an international data linkage study |
spellingShingle |
Congenital anomalies in children with pre‐ or perinatally acquired cerebral palsy: an international data linkage study Goldsmith, Shona Congenital Anomalies Children European Surveillance of Congenital Anomalies EUROCAT Anomalias Congénitas Paralisia Cerebral Estados de Saúde e de Doença Registos Epidemiológicos Registo Nacional de Anomalias Congénitas RENAC Programa Nacional de Vigilância da Paralisia Cerebral PNVPC Europe Portugal |
title_short |
Congenital anomalies in children with pre‐ or perinatally acquired cerebral palsy: an international data linkage study |
title_full |
Congenital anomalies in children with pre‐ or perinatally acquired cerebral palsy: an international data linkage study |
title_fullStr |
Congenital anomalies in children with pre‐ or perinatally acquired cerebral palsy: an international data linkage study |
title_full_unstemmed |
Congenital anomalies in children with pre‐ or perinatally acquired cerebral palsy: an international data linkage study |
title_sort |
Congenital anomalies in children with pre‐ or perinatally acquired cerebral palsy: an international data linkage study |
author |
Goldsmith, Shona |
author_facet |
Goldsmith, Shona Mcintyre, Sarah Andersen, Guro L Gibson, Catherine Himmelmann, Kate Blair, Eve Badawi, Nadia Smithers‐Sheedy, Hayley Garne, Ester Comprehensive CA-CP Study Group |
author_role |
author |
author2 |
Mcintyre, Sarah Andersen, Guro L Gibson, Catherine Himmelmann, Kate Blair, Eve Badawi, Nadia Smithers‐Sheedy, Hayley Garne, Ester Comprehensive CA-CP Study Group |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Goldsmith, Shona Mcintyre, Sarah Andersen, Guro L Gibson, Catherine Himmelmann, Kate Blair, Eve Badawi, Nadia Smithers‐Sheedy, Hayley Garne, Ester Comprehensive CA-CP Study Group |
dc.subject.por.fl_str_mv |
Congenital Anomalies Children European Surveillance of Congenital Anomalies EUROCAT Anomalias Congénitas Paralisia Cerebral Estados de Saúde e de Doença Registos Epidemiológicos Registo Nacional de Anomalias Congénitas RENAC Programa Nacional de Vigilância da Paralisia Cerebral PNVPC Europe Portugal |
topic |
Congenital Anomalies Children European Surveillance of Congenital Anomalies EUROCAT Anomalias Congénitas Paralisia Cerebral Estados de Saúde e de Doença Registos Epidemiológicos Registo Nacional de Anomalias Congénitas RENAC Programa Nacional de Vigilância da Paralisia Cerebral PNVPC Europe Portugal |
description |
Members of the Comprehensive CA-CP study group: Paula Braz and Daniel Virella, Portugal. Departamento de Epidemiologia do INSA |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-06-24 2020-06-24T00:00:00Z 2021-03-06T16:18:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/7349 |
url |
http://hdl.handle.net/10400.18/7349 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Dev Med Child Neurol. 2021 Apr;63(4):413-420. doi: 10.1111/dmcn.14602. Epub 2020 Jun 24. 0012-1622 10.1111/dmcn.14602 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley/ Mac Keith Press |
publisher.none.fl_str_mv |
Wiley/ Mac Keith Press |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132163842506752 |