Effects of environmental pharmaceuticals on physiological parameters of marine mussels Mytilus galloprovincialis
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Tipo de documento: | Dissertação |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/19868 |
Resumo: | The increasing consumption of pharmaceutical products is of environmental concern, as excreted parent compounds and their possibly active metabolites are not completely removed by wastewater treatment plants. Several studies have confirmed the occurrence of antidepressants in coastal waters in the ng/L concentration range. This research focuses on four antidepressants e.g. fluoxetine, FLX; sertraline, SERT; and citalopram, CITA (selective serotonin reuptake inhibitors, SSRIs) and venlafaxine, VEX (serotonin-norepinephrine re-uptake inhibitor, SNRI) and two metabolites norfluoxetine, NF and O-desmethylvenlafaxine, ODV, chosen because: serotonin and norepinephrine are the main invertebrate neuromodulators, thus changing their levels influences animal functions; antidepressants are among the top prescribed pharmaceuticals worldwide, biologically active at low concentrations with the potential to cause neuroendocrine disruption. This work aimed to observe difference in the toxicity among parent compounds, and the relative toxicity of metabolites. The effects have been measured on early life stages of Mediterranean mussel Mytilus galloprovincialis analyzing different end points after exposure to environmental concentration range (0.5 - 500 ng/L). SSRIs had greater effect on fertilization rate than SNRIs, with a similar effect by parent compound and metabolites. SERT caused the highest percentage of unfertilized eggs in a wide range of concentrations, from 10 ng/L to 500ng/L. The range of effect on embryo – larval development is as follows NF (5 -500 ng/L) > SERT (25-500 ng/L) > FLX (100-500 ng/L) > CITA (500 ng/L), while VEN and ODV were ineffective. Poor effects of antidepressants were observed on larvae motility and survival. In conclusion antidepressants and their metabolites affected mussel gamete fertilization and embryo development, thus representing a threat for the formation and maintenance of populations, disrupting the ecological system and biodiversity. |
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Effects of environmental pharmaceuticals on physiological parameters of marine mussels Mytilus galloprovincialisAntidepressantsMarine environmentMytilus galloprovincialisFertilizationEmbryo developmentDomínio/Área Científica::Ciências Naturais::Outras Ciências NaturaisThe increasing consumption of pharmaceutical products is of environmental concern, as excreted parent compounds and their possibly active metabolites are not completely removed by wastewater treatment plants. Several studies have confirmed the occurrence of antidepressants in coastal waters in the ng/L concentration range. This research focuses on four antidepressants e.g. fluoxetine, FLX; sertraline, SERT; and citalopram, CITA (selective serotonin reuptake inhibitors, SSRIs) and venlafaxine, VEX (serotonin-norepinephrine re-uptake inhibitor, SNRI) and two metabolites norfluoxetine, NF and O-desmethylvenlafaxine, ODV, chosen because: serotonin and norepinephrine are the main invertebrate neuromodulators, thus changing their levels influences animal functions; antidepressants are among the top prescribed pharmaceuticals worldwide, biologically active at low concentrations with the potential to cause neuroendocrine disruption. This work aimed to observe difference in the toxicity among parent compounds, and the relative toxicity of metabolites. The effects have been measured on early life stages of Mediterranean mussel Mytilus galloprovincialis analyzing different end points after exposure to environmental concentration range (0.5 - 500 ng/L). SSRIs had greater effect on fertilization rate than SNRIs, with a similar effect by parent compound and metabolites. SERT caused the highest percentage of unfertilized eggs in a wide range of concentrations, from 10 ng/L to 500ng/L. The range of effect on embryo – larval development is as follows NF (5 -500 ng/L) > SERT (25-500 ng/L) > FLX (100-500 ng/L) > CITA (500 ng/L), while VEN and ODV were ineffective. Poor effects of antidepressants were observed on larvae motility and survival. In conclusion antidepressants and their metabolites affected mussel gamete fertilization and embryo development, thus representing a threat for the formation and maintenance of populations, disrupting the ecological system and biodiversity.Fabbr, ElenaRafiq, AyeshaCapolupo, MarcoSapientiaLeopold, Viergine2023-07-25T12:03:53Z2023-02-012023-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10400.1/19868TID:203230183enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-02T02:02:00Zoai:sapientia.ualg.pt:10400.1/19868Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:09:46.020961Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Effects of environmental pharmaceuticals on physiological parameters of marine mussels Mytilus galloprovincialis |
title |
Effects of environmental pharmaceuticals on physiological parameters of marine mussels Mytilus galloprovincialis |
spellingShingle |
Effects of environmental pharmaceuticals on physiological parameters of marine mussels Mytilus galloprovincialis Leopold, Viergine Antidepressants Marine environment Mytilus galloprovincialis Fertilization Embryo development Domínio/Área Científica::Ciências Naturais::Outras Ciências Naturais |
title_short |
Effects of environmental pharmaceuticals on physiological parameters of marine mussels Mytilus galloprovincialis |
title_full |
Effects of environmental pharmaceuticals on physiological parameters of marine mussels Mytilus galloprovincialis |
title_fullStr |
Effects of environmental pharmaceuticals on physiological parameters of marine mussels Mytilus galloprovincialis |
title_full_unstemmed |
Effects of environmental pharmaceuticals on physiological parameters of marine mussels Mytilus galloprovincialis |
title_sort |
Effects of environmental pharmaceuticals on physiological parameters of marine mussels Mytilus galloprovincialis |
author |
Leopold, Viergine |
author_facet |
Leopold, Viergine |
author_role |
author |
dc.contributor.none.fl_str_mv |
Fabbr, Elena Rafiq, Ayesha Capolupo, Marco Sapientia |
dc.contributor.author.fl_str_mv |
Leopold, Viergine |
dc.subject.por.fl_str_mv |
Antidepressants Marine environment Mytilus galloprovincialis Fertilization Embryo development Domínio/Área Científica::Ciências Naturais::Outras Ciências Naturais |
topic |
Antidepressants Marine environment Mytilus galloprovincialis Fertilization Embryo development Domínio/Área Científica::Ciências Naturais::Outras Ciências Naturais |
description |
The increasing consumption of pharmaceutical products is of environmental concern, as excreted parent compounds and their possibly active metabolites are not completely removed by wastewater treatment plants. Several studies have confirmed the occurrence of antidepressants in coastal waters in the ng/L concentration range. This research focuses on four antidepressants e.g. fluoxetine, FLX; sertraline, SERT; and citalopram, CITA (selective serotonin reuptake inhibitors, SSRIs) and venlafaxine, VEX (serotonin-norepinephrine re-uptake inhibitor, SNRI) and two metabolites norfluoxetine, NF and O-desmethylvenlafaxine, ODV, chosen because: serotonin and norepinephrine are the main invertebrate neuromodulators, thus changing their levels influences animal functions; antidepressants are among the top prescribed pharmaceuticals worldwide, biologically active at low concentrations with the potential to cause neuroendocrine disruption. This work aimed to observe difference in the toxicity among parent compounds, and the relative toxicity of metabolites. The effects have been measured on early life stages of Mediterranean mussel Mytilus galloprovincialis analyzing different end points after exposure to environmental concentration range (0.5 - 500 ng/L). SSRIs had greater effect on fertilization rate than SNRIs, with a similar effect by parent compound and metabolites. SERT caused the highest percentage of unfertilized eggs in a wide range of concentrations, from 10 ng/L to 500ng/L. The range of effect on embryo – larval development is as follows NF (5 -500 ng/L) > SERT (25-500 ng/L) > FLX (100-500 ng/L) > CITA (500 ng/L), while VEN and ODV were ineffective. Poor effects of antidepressants were observed on larvae motility and survival. In conclusion antidepressants and their metabolites affected mussel gamete fertilization and embryo development, thus representing a threat for the formation and maintenance of populations, disrupting the ecological system and biodiversity. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-25T12:03:53Z 2023-02-01 2023-02-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/19868 TID:203230183 |
url |
http://hdl.handle.net/10400.1/19868 |
identifier_str_mv |
TID:203230183 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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