Effects of environmental pharmaceuticals on physiological parameters of marine mussels Mytilus galloprovincialis

Detalhes bibliográficos
Autor(a) principal: Leopold, Viergine
Data de Publicação: 2023
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.1/19868
Resumo: The increasing consumption of pharmaceutical products is of environmental concern, as excreted parent compounds and their possibly active metabolites are not completely removed by wastewater treatment plants. Several studies have confirmed the occurrence of antidepressants in coastal waters in the ng/L concentration range. This research focuses on four antidepressants e.g. fluoxetine, FLX; sertraline, SERT; and citalopram, CITA (selective serotonin reuptake inhibitors, SSRIs) and venlafaxine, VEX (serotonin-norepinephrine re-uptake inhibitor, SNRI) and two metabolites norfluoxetine, NF and O-desmethylvenlafaxine, ODV, chosen because: serotonin and norepinephrine are the main invertebrate neuromodulators, thus changing their levels influences animal functions; antidepressants are among the top prescribed pharmaceuticals worldwide, biologically active at low concentrations with the potential to cause neuroendocrine disruption. This work aimed to observe difference in the toxicity among parent compounds, and the relative toxicity of metabolites. The effects have been measured on early life stages of Mediterranean mussel Mytilus galloprovincialis analyzing different end points after exposure to environmental concentration range (0.5 - 500 ng/L). SSRIs had greater effect on fertilization rate than SNRIs, with a similar effect by parent compound and metabolites. SERT caused the highest percentage of unfertilized eggs in a wide range of concentrations, from 10 ng/L to 500ng/L. The range of effect on embryo – larval development is as follows NF (5 -500 ng/L) > SERT (25-500 ng/L) > FLX (100-500 ng/L) > CITA (500 ng/L), while VEN and ODV were ineffective. Poor effects of antidepressants were observed on larvae motility and survival. In conclusion antidepressants and their metabolites affected mussel gamete fertilization and embryo development, thus representing a threat for the formation and maintenance of populations, disrupting the ecological system and biodiversity.
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spelling Effects of environmental pharmaceuticals on physiological parameters of marine mussels Mytilus galloprovincialisAntidepressantsMarine environmentMytilus galloprovincialisFertilizationEmbryo developmentDomínio/Área Científica::Ciências Naturais::Outras Ciências NaturaisThe increasing consumption of pharmaceutical products is of environmental concern, as excreted parent compounds and their possibly active metabolites are not completely removed by wastewater treatment plants. Several studies have confirmed the occurrence of antidepressants in coastal waters in the ng/L concentration range. This research focuses on four antidepressants e.g. fluoxetine, FLX; sertraline, SERT; and citalopram, CITA (selective serotonin reuptake inhibitors, SSRIs) and venlafaxine, VEX (serotonin-norepinephrine re-uptake inhibitor, SNRI) and two metabolites norfluoxetine, NF and O-desmethylvenlafaxine, ODV, chosen because: serotonin and norepinephrine are the main invertebrate neuromodulators, thus changing their levels influences animal functions; antidepressants are among the top prescribed pharmaceuticals worldwide, biologically active at low concentrations with the potential to cause neuroendocrine disruption. This work aimed to observe difference in the toxicity among parent compounds, and the relative toxicity of metabolites. The effects have been measured on early life stages of Mediterranean mussel Mytilus galloprovincialis analyzing different end points after exposure to environmental concentration range (0.5 - 500 ng/L). SSRIs had greater effect on fertilization rate than SNRIs, with a similar effect by parent compound and metabolites. SERT caused the highest percentage of unfertilized eggs in a wide range of concentrations, from 10 ng/L to 500ng/L. The range of effect on embryo – larval development is as follows NF (5 -500 ng/L) > SERT (25-500 ng/L) > FLX (100-500 ng/L) > CITA (500 ng/L), while VEN and ODV were ineffective. Poor effects of antidepressants were observed on larvae motility and survival. In conclusion antidepressants and their metabolites affected mussel gamete fertilization and embryo development, thus representing a threat for the formation and maintenance of populations, disrupting the ecological system and biodiversity.Fabbr, ElenaRafiq, AyeshaCapolupo, MarcoSapientiaLeopold, Viergine2023-07-25T12:03:53Z2023-02-012023-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10400.1/19868TID:203230183enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-02T02:02:00Zoai:sapientia.ualg.pt:10400.1/19868Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:09:46.020961Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Effects of environmental pharmaceuticals on physiological parameters of marine mussels Mytilus galloprovincialis
title Effects of environmental pharmaceuticals on physiological parameters of marine mussels Mytilus galloprovincialis
spellingShingle Effects of environmental pharmaceuticals on physiological parameters of marine mussels Mytilus galloprovincialis
Leopold, Viergine
Antidepressants
Marine environment
Mytilus galloprovincialis
Fertilization
Embryo development
Domínio/Área Científica::Ciências Naturais::Outras Ciências Naturais
title_short Effects of environmental pharmaceuticals on physiological parameters of marine mussels Mytilus galloprovincialis
title_full Effects of environmental pharmaceuticals on physiological parameters of marine mussels Mytilus galloprovincialis
title_fullStr Effects of environmental pharmaceuticals on physiological parameters of marine mussels Mytilus galloprovincialis
title_full_unstemmed Effects of environmental pharmaceuticals on physiological parameters of marine mussels Mytilus galloprovincialis
title_sort Effects of environmental pharmaceuticals on physiological parameters of marine mussels Mytilus galloprovincialis
author Leopold, Viergine
author_facet Leopold, Viergine
author_role author
dc.contributor.none.fl_str_mv Fabbr, Elena
Rafiq, Ayesha
Capolupo, Marco
Sapientia
dc.contributor.author.fl_str_mv Leopold, Viergine
dc.subject.por.fl_str_mv Antidepressants
Marine environment
Mytilus galloprovincialis
Fertilization
Embryo development
Domínio/Área Científica::Ciências Naturais::Outras Ciências Naturais
topic Antidepressants
Marine environment
Mytilus galloprovincialis
Fertilization
Embryo development
Domínio/Área Científica::Ciências Naturais::Outras Ciências Naturais
description The increasing consumption of pharmaceutical products is of environmental concern, as excreted parent compounds and their possibly active metabolites are not completely removed by wastewater treatment plants. Several studies have confirmed the occurrence of antidepressants in coastal waters in the ng/L concentration range. This research focuses on four antidepressants e.g. fluoxetine, FLX; sertraline, SERT; and citalopram, CITA (selective serotonin reuptake inhibitors, SSRIs) and venlafaxine, VEX (serotonin-norepinephrine re-uptake inhibitor, SNRI) and two metabolites norfluoxetine, NF and O-desmethylvenlafaxine, ODV, chosen because: serotonin and norepinephrine are the main invertebrate neuromodulators, thus changing their levels influences animal functions; antidepressants are among the top prescribed pharmaceuticals worldwide, biologically active at low concentrations with the potential to cause neuroendocrine disruption. This work aimed to observe difference in the toxicity among parent compounds, and the relative toxicity of metabolites. The effects have been measured on early life stages of Mediterranean mussel Mytilus galloprovincialis analyzing different end points after exposure to environmental concentration range (0.5 - 500 ng/L). SSRIs had greater effect on fertilization rate than SNRIs, with a similar effect by parent compound and metabolites. SERT caused the highest percentage of unfertilized eggs in a wide range of concentrations, from 10 ng/L to 500ng/L. The range of effect on embryo – larval development is as follows NF (5 -500 ng/L) > SERT (25-500 ng/L) > FLX (100-500 ng/L) > CITA (500 ng/L), while VEN and ODV were ineffective. Poor effects of antidepressants were observed on larvae motility and survival. In conclusion antidepressants and their metabolites affected mussel gamete fertilization and embryo development, thus representing a threat for the formation and maintenance of populations, disrupting the ecological system and biodiversity.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-25T12:03:53Z
2023-02-01
2023-02-01T00:00:00Z
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