HIV-1 Infection in Cyprus, the Eastern Mediterranean European Frontier
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/116684 |
Resumo: | Since HIV-1 treatment is increasingly considered an effective preventionstrategy, it is important to study local HIV-1 epidemics to formulate tailored preventionpolicies. The prevalence of HIV-1 in Cyprus was historically low until 2005. To investigatethe shift in epidemiological trends, we studied the transmission dynamics of HIV-1 in Cyprususing a densely sampled Cypriot HIV-1 transmission cohort that included 85 percent ofHIV-1-infected individuals linked to clinical care between 1986 and 2012 based on detailedclinical, epidemiological, behavioral and HIV-1 genetic information. Subtyping andtransmission cluster reconstruction were performed using maximum likelihood and Bayesianmethods, and the transmission chain network was linked to the clinical, epidemiological andbehavioral data. The results reveal that for the main HIV-1 subtype A1 and B sub-epidemics,young and drug-naïve HIV-1-infected individuals in Cyprus are driving the dynamics of thelocal HIV-1 epidemic. The results of this study provide a better understanding of thedynamics of the HIV-1 infection in Cyprus, which may impact the development of preventionstrategies. Furthermore, this methodology for analyzing densely sampled transmissiondynamics is applicable to other geographic regions to implement effective HIV-1 preventionstrategies in local settings. |
id |
RCAP_204af66fce5f3ddd27cab176cc53ec57 |
---|---|
oai_identifier_str |
oai:run.unl.pt:10362/116684 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
HIV-1 Infection in Cyprus, the Eastern Mediterranean European FrontierA Densely Sampled Transmission Dynamics Analysis from 1986 to 2012EpidemiologyVirologyBiochemistry, Genetics and Molecular Biology (miscellaneous)SDG 3 - Good Health and Well-beingSince HIV-1 treatment is increasingly considered an effective preventionstrategy, it is important to study local HIV-1 epidemics to formulate tailored preventionpolicies. The prevalence of HIV-1 in Cyprus was historically low until 2005. To investigatethe shift in epidemiological trends, we studied the transmission dynamics of HIV-1 in Cyprususing a densely sampled Cypriot HIV-1 transmission cohort that included 85 percent ofHIV-1-infected individuals linked to clinical care between 1986 and 2012 based on detailedclinical, epidemiological, behavioral and HIV-1 genetic information. Subtyping andtransmission cluster reconstruction were performed using maximum likelihood and Bayesianmethods, and the transmission chain network was linked to the clinical, epidemiological andbehavioral data. The results reveal that for the main HIV-1 subtype A1 and B sub-epidemics,young and drug-naïve HIV-1-infected individuals in Cyprus are driving the dynamics of thelocal HIV-1 epidemic. The results of this study provide a better understanding of thedynamics of the HIV-1 infection in Cyprus, which may impact the development of preventionstrategies. Furthermore, this methodology for analyzing densely sampled transmissiondynamics is applicable to other geographic regions to implement effective HIV-1 preventionstrategies in local settings.TB, HIV and opportunistic diseases and pathogens (THOP)Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)RUNPineda-Peña, Andrea ClemenciaTheys, KristofStylianou, Dora C.Demetriades, IoannisPuchhammer, ElisabethVandamme, Anne MiekeAleksiev, IvailoLepej, Snjezana ZidovecLinka, MarekFonager, JannikLiitsola, KirsiKaiser, RolfHamouda, OsamahParaskevis, DimitriosCoughlan, SuzieGrossman, ZehavaMor, OrnaZazzi, MaurizioGriskevicius, AlgirdasLipnickiene, VilneleDevaux, CaroleBoucher, CharlesHofstra, MarijeWensing, AnnemarieBakken-Kran, Anne MarteHorban, AndrzejCamacho, RicardoParaschiv, SimonaOtelea, DanStanojevic, MajaStanekova, DanikaPoljak, MarioGarcia, FedericoParedes, RogerAlbert, JanAbecasis, Ana B.Kostrikis, Leondios G.2021-05-02T22:37:19Z2018-12-012018-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/116684eng2045-2322PURE: 3956806https://doi.org/10.1038/s41598-017-19080-5info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:59:21Zoai:run.unl.pt:10362/116684Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:43:12.123960Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
HIV-1 Infection in Cyprus, the Eastern Mediterranean European Frontier A Densely Sampled Transmission Dynamics Analysis from 1986 to 2012 |
title |
HIV-1 Infection in Cyprus, the Eastern Mediterranean European Frontier |
spellingShingle |
HIV-1 Infection in Cyprus, the Eastern Mediterranean European Frontier Pineda-Peña, Andrea Clemencia Epidemiology Virology Biochemistry, Genetics and Molecular Biology (miscellaneous) SDG 3 - Good Health and Well-being |
title_short |
HIV-1 Infection in Cyprus, the Eastern Mediterranean European Frontier |
title_full |
HIV-1 Infection in Cyprus, the Eastern Mediterranean European Frontier |
title_fullStr |
HIV-1 Infection in Cyprus, the Eastern Mediterranean European Frontier |
title_full_unstemmed |
HIV-1 Infection in Cyprus, the Eastern Mediterranean European Frontier |
title_sort |
HIV-1 Infection in Cyprus, the Eastern Mediterranean European Frontier |
author |
Pineda-Peña, Andrea Clemencia |
author_facet |
Pineda-Peña, Andrea Clemencia Theys, Kristof Stylianou, Dora C. Demetriades, Ioannis Puchhammer, Elisabeth Vandamme, Anne Mieke Aleksiev, Ivailo Lepej, Snjezana Zidovec Linka, Marek Fonager, Jannik Liitsola, Kirsi Kaiser, Rolf Hamouda, Osamah Paraskevis, Dimitrios Coughlan, Suzie Grossman, Zehava Mor, Orna Zazzi, Maurizio Griskevicius, Algirdas Lipnickiene, Vilnele Devaux, Carole Boucher, Charles Hofstra, Marije Wensing, Annemarie Bakken-Kran, Anne Marte Horban, Andrzej Camacho, Ricardo Paraschiv, Simona Otelea, Dan Stanojevic, Maja Stanekova, Danika Poljak, Mario Garcia, Federico Paredes, Roger Albert, Jan Abecasis, Ana B. Kostrikis, Leondios G. |
author_role |
author |
author2 |
Theys, Kristof Stylianou, Dora C. Demetriades, Ioannis Puchhammer, Elisabeth Vandamme, Anne Mieke Aleksiev, Ivailo Lepej, Snjezana Zidovec Linka, Marek Fonager, Jannik Liitsola, Kirsi Kaiser, Rolf Hamouda, Osamah Paraskevis, Dimitrios Coughlan, Suzie Grossman, Zehava Mor, Orna Zazzi, Maurizio Griskevicius, Algirdas Lipnickiene, Vilnele Devaux, Carole Boucher, Charles Hofstra, Marije Wensing, Annemarie Bakken-Kran, Anne Marte Horban, Andrzej Camacho, Ricardo Paraschiv, Simona Otelea, Dan Stanojevic, Maja Stanekova, Danika Poljak, Mario Garcia, Federico Paredes, Roger Albert, Jan Abecasis, Ana B. Kostrikis, Leondios G. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
TB, HIV and opportunistic diseases and pathogens (THOP) Instituto de Higiene e Medicina Tropical (IHMT) Global Health and Tropical Medicine (GHTM) RUN |
dc.contributor.author.fl_str_mv |
Pineda-Peña, Andrea Clemencia Theys, Kristof Stylianou, Dora C. Demetriades, Ioannis Puchhammer, Elisabeth Vandamme, Anne Mieke Aleksiev, Ivailo Lepej, Snjezana Zidovec Linka, Marek Fonager, Jannik Liitsola, Kirsi Kaiser, Rolf Hamouda, Osamah Paraskevis, Dimitrios Coughlan, Suzie Grossman, Zehava Mor, Orna Zazzi, Maurizio Griskevicius, Algirdas Lipnickiene, Vilnele Devaux, Carole Boucher, Charles Hofstra, Marije Wensing, Annemarie Bakken-Kran, Anne Marte Horban, Andrzej Camacho, Ricardo Paraschiv, Simona Otelea, Dan Stanojevic, Maja Stanekova, Danika Poljak, Mario Garcia, Federico Paredes, Roger Albert, Jan Abecasis, Ana B. Kostrikis, Leondios G. |
dc.subject.por.fl_str_mv |
Epidemiology Virology Biochemistry, Genetics and Molecular Biology (miscellaneous) SDG 3 - Good Health and Well-being |
topic |
Epidemiology Virology Biochemistry, Genetics and Molecular Biology (miscellaneous) SDG 3 - Good Health and Well-being |
description |
Since HIV-1 treatment is increasingly considered an effective preventionstrategy, it is important to study local HIV-1 epidemics to formulate tailored preventionpolicies. The prevalence of HIV-1 in Cyprus was historically low until 2005. To investigatethe shift in epidemiological trends, we studied the transmission dynamics of HIV-1 in Cyprususing a densely sampled Cypriot HIV-1 transmission cohort that included 85 percent ofHIV-1-infected individuals linked to clinical care between 1986 and 2012 based on detailedclinical, epidemiological, behavioral and HIV-1 genetic information. Subtyping andtransmission cluster reconstruction were performed using maximum likelihood and Bayesianmethods, and the transmission chain network was linked to the clinical, epidemiological andbehavioral data. The results reveal that for the main HIV-1 subtype A1 and B sub-epidemics,young and drug-naïve HIV-1-infected individuals in Cyprus are driving the dynamics of thelocal HIV-1 epidemic. The results of this study provide a better understanding of thedynamics of the HIV-1 infection in Cyprus, which may impact the development of preventionstrategies. Furthermore, this methodology for analyzing densely sampled transmissiondynamics is applicable to other geographic regions to implement effective HIV-1 preventionstrategies in local settings. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-01 2018-12-01T00:00:00Z 2021-05-02T22:37:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/116684 |
url |
http://hdl.handle.net/10362/116684 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2045-2322 PURE: 3956806 https://doi.org/10.1038/s41598-017-19080-5 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799138041998082048 |