Use of various sugarcane byproducts to produce lipid extracts with bioactive properties: physicochemical and biological characterization
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.14/44075 |
Resumo: | Sugarcane, a globally cultivated crop constituting nearly 80% of total sugar production, yields residues from harvesting and sugar production known for their renewable bioactive compounds with health-promoting properties. Despite previous studies, the intricate interplay of extracts from diverse sugarcane byproducts and their biological attributes remains underexplored. This study focused on extracting the lipid fraction from a blend of selected sugarcane byproducts (straw, bagasse, and filter cake) using ethanol. The resulting extract underwent comprehensive characterization, including physicochemical analysis (FT-IR, DSC, particle size distribution, and color) and chemical composition assessment (GC-MS). The biological properties were evaluated through antihypertensive (ACE), anticholesterolemic (HMG-CoA reductase), and antidiabetic (alpha-glucosidase and Dipeptidyl Peptidase-IV) assays, alongside in vitro biocompatibility assessments in Caco-2 and Hep G2 cells. The phytochemicals identified, such as β-sitosterol and 1-octacosanol, likely contribute to the extract’s antidiabetic, anticholesterolemic, and antihypertensive potential, given their association with various beneficial bioactivities. The extract exhibited substantial antidiabetic effects, inhibiting α-glucosidase (5–60%) and DPP-IV activity (25–100%), anticholesterolemic potential with HMG-CoA reductase inhibition (11.4–63.2%), and antihypertensive properties through ACE inhibition (24.0–27.3%). These findings lay the groundwork for incorporating these ingredients into the development of food supplements or nutraceuticals, offering potential for preventing and managing metabolic syndrome-associated conditions. |
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Use of various sugarcane byproducts to produce lipid extracts with bioactive properties: physicochemical and biological characterizationSugarcaneLipid extractAntidiabeticAnticholesterolemicAntihypertensionSugarcane, a globally cultivated crop constituting nearly 80% of total sugar production, yields residues from harvesting and sugar production known for their renewable bioactive compounds with health-promoting properties. Despite previous studies, the intricate interplay of extracts from diverse sugarcane byproducts and their biological attributes remains underexplored. This study focused on extracting the lipid fraction from a blend of selected sugarcane byproducts (straw, bagasse, and filter cake) using ethanol. The resulting extract underwent comprehensive characterization, including physicochemical analysis (FT-IR, DSC, particle size distribution, and color) and chemical composition assessment (GC-MS). The biological properties were evaluated through antihypertensive (ACE), anticholesterolemic (HMG-CoA reductase), and antidiabetic (alpha-glucosidase and Dipeptidyl Peptidase-IV) assays, alongside in vitro biocompatibility assessments in Caco-2 and Hep G2 cells. The phytochemicals identified, such as β-sitosterol and 1-octacosanol, likely contribute to the extract’s antidiabetic, anticholesterolemic, and antihypertensive potential, given their association with various beneficial bioactivities. The extract exhibited substantial antidiabetic effects, inhibiting α-glucosidase (5–60%) and DPP-IV activity (25–100%), anticholesterolemic potential with HMG-CoA reductase inhibition (11.4–63.2%), and antihypertensive properties through ACE inhibition (24.0–27.3%). These findings lay the groundwork for incorporating these ingredients into the development of food supplements or nutraceuticals, offering potential for preventing and managing metabolic syndrome-associated conditions.Veritati - Repositório Institucional da Universidade Católica PortuguesaPereira, Joana OdilaOliveira, DianaFaustino, MargaridaVidigal, Susana S. M. P.Pereira, Ana MargaridaFerreira, Carlos M. H.Oliveira, Ana SofiaDurão, JoanaRodríguez-Alcalá, Luís M.Pintado, Manuela E.Madureira, Ana RaquelCarvalho, Ana P.2024-02-23T11:11:42Z2024-02-172024-02-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/44075eng2218-273X10.3390/biom140202338518589889138397470info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-12T01:38:34Zoai:repositorio.ucp.pt:10400.14/44075Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:11:37.691497Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Use of various sugarcane byproducts to produce lipid extracts with bioactive properties: physicochemical and biological characterization |
title |
Use of various sugarcane byproducts to produce lipid extracts with bioactive properties: physicochemical and biological characterization |
spellingShingle |
Use of various sugarcane byproducts to produce lipid extracts with bioactive properties: physicochemical and biological characterization Pereira, Joana Odila Sugarcane Lipid extract Antidiabetic Anticholesterolemic Antihypertension |
title_short |
Use of various sugarcane byproducts to produce lipid extracts with bioactive properties: physicochemical and biological characterization |
title_full |
Use of various sugarcane byproducts to produce lipid extracts with bioactive properties: physicochemical and biological characterization |
title_fullStr |
Use of various sugarcane byproducts to produce lipid extracts with bioactive properties: physicochemical and biological characterization |
title_full_unstemmed |
Use of various sugarcane byproducts to produce lipid extracts with bioactive properties: physicochemical and biological characterization |
title_sort |
Use of various sugarcane byproducts to produce lipid extracts with bioactive properties: physicochemical and biological characterization |
author |
Pereira, Joana Odila |
author_facet |
Pereira, Joana Odila Oliveira, Diana Faustino, Margarida Vidigal, Susana S. M. P. Pereira, Ana Margarida Ferreira, Carlos M. H. Oliveira, Ana Sofia Durão, Joana Rodríguez-Alcalá, Luís M. Pintado, Manuela E. Madureira, Ana Raquel Carvalho, Ana P. |
author_role |
author |
author2 |
Oliveira, Diana Faustino, Margarida Vidigal, Susana S. M. P. Pereira, Ana Margarida Ferreira, Carlos M. H. Oliveira, Ana Sofia Durão, Joana Rodríguez-Alcalá, Luís M. Pintado, Manuela E. Madureira, Ana Raquel Carvalho, Ana P. |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Veritati - Repositório Institucional da Universidade Católica Portuguesa |
dc.contributor.author.fl_str_mv |
Pereira, Joana Odila Oliveira, Diana Faustino, Margarida Vidigal, Susana S. M. P. Pereira, Ana Margarida Ferreira, Carlos M. H. Oliveira, Ana Sofia Durão, Joana Rodríguez-Alcalá, Luís M. Pintado, Manuela E. Madureira, Ana Raquel Carvalho, Ana P. |
dc.subject.por.fl_str_mv |
Sugarcane Lipid extract Antidiabetic Anticholesterolemic Antihypertension |
topic |
Sugarcane Lipid extract Antidiabetic Anticholesterolemic Antihypertension |
description |
Sugarcane, a globally cultivated crop constituting nearly 80% of total sugar production, yields residues from harvesting and sugar production known for their renewable bioactive compounds with health-promoting properties. Despite previous studies, the intricate interplay of extracts from diverse sugarcane byproducts and their biological attributes remains underexplored. This study focused on extracting the lipid fraction from a blend of selected sugarcane byproducts (straw, bagasse, and filter cake) using ethanol. The resulting extract underwent comprehensive characterization, including physicochemical analysis (FT-IR, DSC, particle size distribution, and color) and chemical composition assessment (GC-MS). The biological properties were evaluated through antihypertensive (ACE), anticholesterolemic (HMG-CoA reductase), and antidiabetic (alpha-glucosidase and Dipeptidyl Peptidase-IV) assays, alongside in vitro biocompatibility assessments in Caco-2 and Hep G2 cells. The phytochemicals identified, such as β-sitosterol and 1-octacosanol, likely contribute to the extract’s antidiabetic, anticholesterolemic, and antihypertensive potential, given their association with various beneficial bioactivities. The extract exhibited substantial antidiabetic effects, inhibiting α-glucosidase (5–60%) and DPP-IV activity (25–100%), anticholesterolemic potential with HMG-CoA reductase inhibition (11.4–63.2%), and antihypertensive properties through ACE inhibition (24.0–27.3%). These findings lay the groundwork for incorporating these ingredients into the development of food supplements or nutraceuticals, offering potential for preventing and managing metabolic syndrome-associated conditions. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-02-23T11:11:42Z 2024-02-17 2024-02-17T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.14/44075 |
url |
http://hdl.handle.net/10400.14/44075 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2218-273X 10.3390/biom14020233 85185898891 38397470 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137766320111616 |