Metabolic profiles of ultra-processed food consumption and their role in obesity risk in British children

Detalhes bibliográficos
Autor(a) principal: Handakas, Evangelos
Data de Publicação: 2022
Outros Autores: Chang, Kiara, Khandpur, Neha, Vamos, Eszter P., Millett, Christopher, Sassi, Franco, Vineis, Paolo, Robinson, Oliver
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/153980
Resumo: Funding Information: This study was supported by the postdoctoral fellowship 2016/25853-4DN from Fundação de Amparo à Pesquisa do Estado de São Paulo (NK) . Funding Information: This study was supported by grant 217065/Z/19/Z from the UK Medical Research Council and Wellcome Trust and the University of Bristol (core support for the Avon Longitudinal Study of Parents and Children [ALSPAC]); Funding Information: This study was supported by the STOP project, which received grant 774548 from the European Union's Horizon 2020 research and innovation program. OR was supported by a UKRI Future Leaders Fellowship (MR/S03532X/1). CM and EV are funded by the National Institute for Health and Care Research School for Public Health Research, Grant Reference Number PD-SPH-2015. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. This study was supported by the postdoctoral fellowship 2016/25853-4DN from Fundação de Amparo à Pesquisa do Estado de São Paulo (NK). This study was supported by grant 217065/Z/19/Z from the UK Medical Research Council and Wellcome Trust and the University of Bristol (core support for the Avon Longitudinal Study of Parents and Children [ALSPAC]);, The collection of primary exposure and outcomes data in ALSPAC that were evaluated in this study were supported by grants 076467/Z/05/Z, 086676/Z/08/Z, 086684, 092731 and MC_UU_12013/1 from MRC, grant from Wellcome Trust, grants 5R01HL071248- 07, R01 DK077659 from NIH, grant from British Heart Foundation. A comprehensive list of grant funding is available on the ALSPAC website (http://www.bristol.ac.uk/alspac/external/documents/grantacknowledgements. pdf). Funding Information: CM and EV are funded by the National Institute for Health and Care Research School for Public Health Research , Grant Reference Number PD-SPH-2015 . The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. Funding Information: This study was supported by the STOP project , which received grant 774548 from the European Union's Horizon 2020 research and innovation program . Funding Information: The collection of primary exposure and outcomes data in ALSPAC that were evaluated in this study were supported by grants 076467/Z/05/Z , 086676/Z/08/Z , 086684 , 092731 and MC_UU_12013/1 from MRC , grant from Wellcome Trust , grants 5R01HL071248- 07 , R01 DK077659 from NIH , grant from British Heart Foundation . Funding Information: OR was supported by a UKRI Future Leaders Fellowship ( MR/S03532X/1 ). Publisher Copyright: © 2022 The Authors
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spelling Metabolic profiles of ultra-processed food consumption and their role in obesity risk in British childrenALSPACBody mass indexChildhoodDiet nutrientsMetabolomicsUltra processed foodNutrition and DieteticsCritical Care and Intensive Care MedicineSDG 3 - Good Health and Well-beingFunding Information: This study was supported by the postdoctoral fellowship 2016/25853-4DN from Fundação de Amparo à Pesquisa do Estado de São Paulo (NK) . Funding Information: This study was supported by grant 217065/Z/19/Z from the UK Medical Research Council and Wellcome Trust and the University of Bristol (core support for the Avon Longitudinal Study of Parents and Children [ALSPAC]); Funding Information: This study was supported by the STOP project, which received grant 774548 from the European Union's Horizon 2020 research and innovation program. OR was supported by a UKRI Future Leaders Fellowship (MR/S03532X/1). CM and EV are funded by the National Institute for Health and Care Research School for Public Health Research, Grant Reference Number PD-SPH-2015. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. This study was supported by the postdoctoral fellowship 2016/25853-4DN from Fundação de Amparo à Pesquisa do Estado de São Paulo (NK). This study was supported by grant 217065/Z/19/Z from the UK Medical Research Council and Wellcome Trust and the University of Bristol (core support for the Avon Longitudinal Study of Parents and Children [ALSPAC]);, The collection of primary exposure and outcomes data in ALSPAC that were evaluated in this study were supported by grants 076467/Z/05/Z, 086676/Z/08/Z, 086684, 092731 and MC_UU_12013/1 from MRC, grant from Wellcome Trust, grants 5R01HL071248- 07, R01 DK077659 from NIH, grant from British Heart Foundation. A comprehensive list of grant funding is available on the ALSPAC website (http://www.bristol.ac.uk/alspac/external/documents/grantacknowledgements. pdf). Funding Information: CM and EV are funded by the National Institute for Health and Care Research School for Public Health Research , Grant Reference Number PD-SPH-2015 . The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. Funding Information: This study was supported by the STOP project , which received grant 774548 from the European Union's Horizon 2020 research and innovation program . Funding Information: The collection of primary exposure and outcomes data in ALSPAC that were evaluated in this study were supported by grants 076467/Z/05/Z , 086676/Z/08/Z , 086684 , 092731 and MC_UU_12013/1 from MRC , grant from Wellcome Trust , grants 5R01HL071248- 07 , R01 DK077659 from NIH , grant from British Heart Foundation . Funding Information: OR was supported by a UKRI Future Leaders Fellowship ( MR/S03532X/1 ). Publisher Copyright: © 2022 The AuthorsBackground & aims: Higher consumption of ultra-processed foods (UPF) has been associated with childhood obesity, but underlying mechanisms remain unclear. We investigated plasma nuclear magnetic resonance metabolic profiles of higher UPF consumption and their role in obesity risk in the British ALSPAC cohort. Methods: We performed cross-sectional and prospective metabolome wide association analyses of UPF, calculated from food diaries using the NOVA classification. In cross-sectional analysis, we tested the association between UPF consumption and metabolic profile at 7 years (N = 4528), and in the prospective analysis we tested the association between UPF consumption at 13 years and metabolic profile at 17 years (N = 3086). Effects of UPF-associated metabolites at 7 years on subsequent fat mass accumulation were assessed using growth curve models. Results: At 7 years, UPF was associated with 115 metabolic traits including lower levels of branched-chain and aromatic amino acids and higher levels of citrate, glutamine, and monounsaturated fatty acids, which were also associated with greater fat mass accumulation. Reported intake of nutrients mediated associations with most metabolites, except for citrate. Conclusions: UPF consumption among British children is associated with perturbation of multiple metabolic traits, many of which contribute to child obesity risk.Centro de Investigação em Saúde Pública (CISP/PHRC)Comprehensive Health Research Centre (CHRC) - Pólo ENSPEscola Nacional de Saúde Pública (ENSP)RUNHandakas, EvangelosChang, KiaraKhandpur, NehaVamos, Eszter P.Millett, ChristopherSassi, FrancoVineis, PaoloRobinson, Oliver2023-06-15T22:20:45Z2022-112022-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12application/pdfhttp://hdl.handle.net/10362/153980eng0261-5614PURE: 63726633https://doi.org/10.1016/j.clnu.2022.09.002info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:36:26Zoai:run.unl.pt:10362/153980Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:55:26.902037Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Metabolic profiles of ultra-processed food consumption and their role in obesity risk in British children
title Metabolic profiles of ultra-processed food consumption and their role in obesity risk in British children
spellingShingle Metabolic profiles of ultra-processed food consumption and their role in obesity risk in British children
Handakas, Evangelos
ALSPAC
Body mass index
Childhood
Diet nutrients
Metabolomics
Ultra processed food
Nutrition and Dietetics
Critical Care and Intensive Care Medicine
SDG 3 - Good Health and Well-being
title_short Metabolic profiles of ultra-processed food consumption and their role in obesity risk in British children
title_full Metabolic profiles of ultra-processed food consumption and their role in obesity risk in British children
title_fullStr Metabolic profiles of ultra-processed food consumption and their role in obesity risk in British children
title_full_unstemmed Metabolic profiles of ultra-processed food consumption and their role in obesity risk in British children
title_sort Metabolic profiles of ultra-processed food consumption and their role in obesity risk in British children
author Handakas, Evangelos
author_facet Handakas, Evangelos
Chang, Kiara
Khandpur, Neha
Vamos, Eszter P.
Millett, Christopher
Sassi, Franco
Vineis, Paolo
Robinson, Oliver
author_role author
author2 Chang, Kiara
Khandpur, Neha
Vamos, Eszter P.
Millett, Christopher
Sassi, Franco
Vineis, Paolo
Robinson, Oliver
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centro de Investigação em Saúde Pública (CISP/PHRC)
Comprehensive Health Research Centre (CHRC) - Pólo ENSP
Escola Nacional de Saúde Pública (ENSP)
RUN
dc.contributor.author.fl_str_mv Handakas, Evangelos
Chang, Kiara
Khandpur, Neha
Vamos, Eszter P.
Millett, Christopher
Sassi, Franco
Vineis, Paolo
Robinson, Oliver
dc.subject.por.fl_str_mv ALSPAC
Body mass index
Childhood
Diet nutrients
Metabolomics
Ultra processed food
Nutrition and Dietetics
Critical Care and Intensive Care Medicine
SDG 3 - Good Health and Well-being
topic ALSPAC
Body mass index
Childhood
Diet nutrients
Metabolomics
Ultra processed food
Nutrition and Dietetics
Critical Care and Intensive Care Medicine
SDG 3 - Good Health and Well-being
description Funding Information: This study was supported by the postdoctoral fellowship 2016/25853-4DN from Fundação de Amparo à Pesquisa do Estado de São Paulo (NK) . Funding Information: This study was supported by grant 217065/Z/19/Z from the UK Medical Research Council and Wellcome Trust and the University of Bristol (core support for the Avon Longitudinal Study of Parents and Children [ALSPAC]); Funding Information: This study was supported by the STOP project, which received grant 774548 from the European Union's Horizon 2020 research and innovation program. OR was supported by a UKRI Future Leaders Fellowship (MR/S03532X/1). CM and EV are funded by the National Institute for Health and Care Research School for Public Health Research, Grant Reference Number PD-SPH-2015. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. This study was supported by the postdoctoral fellowship 2016/25853-4DN from Fundação de Amparo à Pesquisa do Estado de São Paulo (NK). This study was supported by grant 217065/Z/19/Z from the UK Medical Research Council and Wellcome Trust and the University of Bristol (core support for the Avon Longitudinal Study of Parents and Children [ALSPAC]);, The collection of primary exposure and outcomes data in ALSPAC that were evaluated in this study were supported by grants 076467/Z/05/Z, 086676/Z/08/Z, 086684, 092731 and MC_UU_12013/1 from MRC, grant from Wellcome Trust, grants 5R01HL071248- 07, R01 DK077659 from NIH, grant from British Heart Foundation. A comprehensive list of grant funding is available on the ALSPAC website (http://www.bristol.ac.uk/alspac/external/documents/grantacknowledgements. pdf). Funding Information: CM and EV are funded by the National Institute for Health and Care Research School for Public Health Research , Grant Reference Number PD-SPH-2015 . The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. Funding Information: This study was supported by the STOP project , which received grant 774548 from the European Union's Horizon 2020 research and innovation program . Funding Information: The collection of primary exposure and outcomes data in ALSPAC that were evaluated in this study were supported by grants 076467/Z/05/Z , 086676/Z/08/Z , 086684 , 092731 and MC_UU_12013/1 from MRC , grant from Wellcome Trust , grants 5R01HL071248- 07 , R01 DK077659 from NIH , grant from British Heart Foundation . Funding Information: OR was supported by a UKRI Future Leaders Fellowship ( MR/S03532X/1 ). Publisher Copyright: © 2022 The Authors
publishDate 2022
dc.date.none.fl_str_mv 2022-11
2022-11-01T00:00:00Z
2023-06-15T22:20:45Z
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dc.language.iso.fl_str_mv eng
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PURE: 63726633
https://doi.org/10.1016/j.clnu.2022.09.002
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