Metabolic profiles of ultra-processed food consumption and their role in obesity risk in British children
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/153980 |
Resumo: | Funding Information: This study was supported by the postdoctoral fellowship 2016/25853-4DN from Fundação de Amparo à Pesquisa do Estado de São Paulo (NK) . Funding Information: This study was supported by grant 217065/Z/19/Z from the UK Medical Research Council and Wellcome Trust and the University of Bristol (core support for the Avon Longitudinal Study of Parents and Children [ALSPAC]); Funding Information: This study was supported by the STOP project, which received grant 774548 from the European Union's Horizon 2020 research and innovation program. OR was supported by a UKRI Future Leaders Fellowship (MR/S03532X/1). CM and EV are funded by the National Institute for Health and Care Research School for Public Health Research, Grant Reference Number PD-SPH-2015. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. This study was supported by the postdoctoral fellowship 2016/25853-4DN from Fundação de Amparo à Pesquisa do Estado de São Paulo (NK). This study was supported by grant 217065/Z/19/Z from the UK Medical Research Council and Wellcome Trust and the University of Bristol (core support for the Avon Longitudinal Study of Parents and Children [ALSPAC]);, The collection of primary exposure and outcomes data in ALSPAC that were evaluated in this study were supported by grants 076467/Z/05/Z, 086676/Z/08/Z, 086684, 092731 and MC_UU_12013/1 from MRC, grant from Wellcome Trust, grants 5R01HL071248- 07, R01 DK077659 from NIH, grant from British Heart Foundation. A comprehensive list of grant funding is available on the ALSPAC website (http://www.bristol.ac.uk/alspac/external/documents/grantacknowledgements. pdf). Funding Information: CM and EV are funded by the National Institute for Health and Care Research School for Public Health Research , Grant Reference Number PD-SPH-2015 . The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. Funding Information: This study was supported by the STOP project , which received grant 774548 from the European Union's Horizon 2020 research and innovation program . Funding Information: The collection of primary exposure and outcomes data in ALSPAC that were evaluated in this study were supported by grants 076467/Z/05/Z , 086676/Z/08/Z , 086684 , 092731 and MC_UU_12013/1 from MRC , grant from Wellcome Trust , grants 5R01HL071248- 07 , R01 DK077659 from NIH , grant from British Heart Foundation . Funding Information: OR was supported by a UKRI Future Leaders Fellowship ( MR/S03532X/1 ). Publisher Copyright: © 2022 The Authors |
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Metabolic profiles of ultra-processed food consumption and their role in obesity risk in British childrenALSPACBody mass indexChildhoodDiet nutrientsMetabolomicsUltra processed foodNutrition and DieteticsCritical Care and Intensive Care MedicineSDG 3 - Good Health and Well-beingFunding Information: This study was supported by the postdoctoral fellowship 2016/25853-4DN from Fundação de Amparo à Pesquisa do Estado de São Paulo (NK) . Funding Information: This study was supported by grant 217065/Z/19/Z from the UK Medical Research Council and Wellcome Trust and the University of Bristol (core support for the Avon Longitudinal Study of Parents and Children [ALSPAC]); Funding Information: This study was supported by the STOP project, which received grant 774548 from the European Union's Horizon 2020 research and innovation program. OR was supported by a UKRI Future Leaders Fellowship (MR/S03532X/1). CM and EV are funded by the National Institute for Health and Care Research School for Public Health Research, Grant Reference Number PD-SPH-2015. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. This study was supported by the postdoctoral fellowship 2016/25853-4DN from Fundação de Amparo à Pesquisa do Estado de São Paulo (NK). This study was supported by grant 217065/Z/19/Z from the UK Medical Research Council and Wellcome Trust and the University of Bristol (core support for the Avon Longitudinal Study of Parents and Children [ALSPAC]);, The collection of primary exposure and outcomes data in ALSPAC that were evaluated in this study were supported by grants 076467/Z/05/Z, 086676/Z/08/Z, 086684, 092731 and MC_UU_12013/1 from MRC, grant from Wellcome Trust, grants 5R01HL071248- 07, R01 DK077659 from NIH, grant from British Heart Foundation. A comprehensive list of grant funding is available on the ALSPAC website (http://www.bristol.ac.uk/alspac/external/documents/grantacknowledgements. pdf). Funding Information: CM and EV are funded by the National Institute for Health and Care Research School for Public Health Research , Grant Reference Number PD-SPH-2015 . The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. Funding Information: This study was supported by the STOP project , which received grant 774548 from the European Union's Horizon 2020 research and innovation program . Funding Information: The collection of primary exposure and outcomes data in ALSPAC that were evaluated in this study were supported by grants 076467/Z/05/Z , 086676/Z/08/Z , 086684 , 092731 and MC_UU_12013/1 from MRC , grant from Wellcome Trust , grants 5R01HL071248- 07 , R01 DK077659 from NIH , grant from British Heart Foundation . Funding Information: OR was supported by a UKRI Future Leaders Fellowship ( MR/S03532X/1 ). Publisher Copyright: © 2022 The AuthorsBackground & aims: Higher consumption of ultra-processed foods (UPF) has been associated with childhood obesity, but underlying mechanisms remain unclear. We investigated plasma nuclear magnetic resonance metabolic profiles of higher UPF consumption and their role in obesity risk in the British ALSPAC cohort. Methods: We performed cross-sectional and prospective metabolome wide association analyses of UPF, calculated from food diaries using the NOVA classification. In cross-sectional analysis, we tested the association between UPF consumption and metabolic profile at 7 years (N = 4528), and in the prospective analysis we tested the association between UPF consumption at 13 years and metabolic profile at 17 years (N = 3086). Effects of UPF-associated metabolites at 7 years on subsequent fat mass accumulation were assessed using growth curve models. Results: At 7 years, UPF was associated with 115 metabolic traits including lower levels of branched-chain and aromatic amino acids and higher levels of citrate, glutamine, and monounsaturated fatty acids, which were also associated with greater fat mass accumulation. Reported intake of nutrients mediated associations with most metabolites, except for citrate. Conclusions: UPF consumption among British children is associated with perturbation of multiple metabolic traits, many of which contribute to child obesity risk.Centro de Investigação em Saúde Pública (CISP/PHRC)Comprehensive Health Research Centre (CHRC) - Pólo ENSPEscola Nacional de Saúde Pública (ENSP)RUNHandakas, EvangelosChang, KiaraKhandpur, NehaVamos, Eszter P.Millett, ChristopherSassi, FrancoVineis, PaoloRobinson, Oliver2023-06-15T22:20:45Z2022-112022-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12application/pdfhttp://hdl.handle.net/10362/153980eng0261-5614PURE: 63726633https://doi.org/10.1016/j.clnu.2022.09.002info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:36:26Zoai:run.unl.pt:10362/153980Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:55:26.902037Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Metabolic profiles of ultra-processed food consumption and their role in obesity risk in British children |
title |
Metabolic profiles of ultra-processed food consumption and their role in obesity risk in British children |
spellingShingle |
Metabolic profiles of ultra-processed food consumption and their role in obesity risk in British children Handakas, Evangelos ALSPAC Body mass index Childhood Diet nutrients Metabolomics Ultra processed food Nutrition and Dietetics Critical Care and Intensive Care Medicine SDG 3 - Good Health and Well-being |
title_short |
Metabolic profiles of ultra-processed food consumption and their role in obesity risk in British children |
title_full |
Metabolic profiles of ultra-processed food consumption and their role in obesity risk in British children |
title_fullStr |
Metabolic profiles of ultra-processed food consumption and their role in obesity risk in British children |
title_full_unstemmed |
Metabolic profiles of ultra-processed food consumption and their role in obesity risk in British children |
title_sort |
Metabolic profiles of ultra-processed food consumption and their role in obesity risk in British children |
author |
Handakas, Evangelos |
author_facet |
Handakas, Evangelos Chang, Kiara Khandpur, Neha Vamos, Eszter P. Millett, Christopher Sassi, Franco Vineis, Paolo Robinson, Oliver |
author_role |
author |
author2 |
Chang, Kiara Khandpur, Neha Vamos, Eszter P. Millett, Christopher Sassi, Franco Vineis, Paolo Robinson, Oliver |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Centro de Investigação em Saúde Pública (CISP/PHRC) Comprehensive Health Research Centre (CHRC) - Pólo ENSP Escola Nacional de Saúde Pública (ENSP) RUN |
dc.contributor.author.fl_str_mv |
Handakas, Evangelos Chang, Kiara Khandpur, Neha Vamos, Eszter P. Millett, Christopher Sassi, Franco Vineis, Paolo Robinson, Oliver |
dc.subject.por.fl_str_mv |
ALSPAC Body mass index Childhood Diet nutrients Metabolomics Ultra processed food Nutrition and Dietetics Critical Care and Intensive Care Medicine SDG 3 - Good Health and Well-being |
topic |
ALSPAC Body mass index Childhood Diet nutrients Metabolomics Ultra processed food Nutrition and Dietetics Critical Care and Intensive Care Medicine SDG 3 - Good Health and Well-being |
description |
Funding Information: This study was supported by the postdoctoral fellowship 2016/25853-4DN from Fundação de Amparo à Pesquisa do Estado de São Paulo (NK) . Funding Information: This study was supported by grant 217065/Z/19/Z from the UK Medical Research Council and Wellcome Trust and the University of Bristol (core support for the Avon Longitudinal Study of Parents and Children [ALSPAC]); Funding Information: This study was supported by the STOP project, which received grant 774548 from the European Union's Horizon 2020 research and innovation program. OR was supported by a UKRI Future Leaders Fellowship (MR/S03532X/1). CM and EV are funded by the National Institute for Health and Care Research School for Public Health Research, Grant Reference Number PD-SPH-2015. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. This study was supported by the postdoctoral fellowship 2016/25853-4DN from Fundação de Amparo à Pesquisa do Estado de São Paulo (NK). This study was supported by grant 217065/Z/19/Z from the UK Medical Research Council and Wellcome Trust and the University of Bristol (core support for the Avon Longitudinal Study of Parents and Children [ALSPAC]);, The collection of primary exposure and outcomes data in ALSPAC that were evaluated in this study were supported by grants 076467/Z/05/Z, 086676/Z/08/Z, 086684, 092731 and MC_UU_12013/1 from MRC, grant from Wellcome Trust, grants 5R01HL071248- 07, R01 DK077659 from NIH, grant from British Heart Foundation. A comprehensive list of grant funding is available on the ALSPAC website (http://www.bristol.ac.uk/alspac/external/documents/grantacknowledgements. pdf). Funding Information: CM and EV are funded by the National Institute for Health and Care Research School for Public Health Research , Grant Reference Number PD-SPH-2015 . The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. Funding Information: This study was supported by the STOP project , which received grant 774548 from the European Union's Horizon 2020 research and innovation program . Funding Information: The collection of primary exposure and outcomes data in ALSPAC that were evaluated in this study were supported by grants 076467/Z/05/Z , 086676/Z/08/Z , 086684 , 092731 and MC_UU_12013/1 from MRC , grant from Wellcome Trust , grants 5R01HL071248- 07 , R01 DK077659 from NIH , grant from British Heart Foundation . Funding Information: OR was supported by a UKRI Future Leaders Fellowship ( MR/S03532X/1 ). Publisher Copyright: © 2022 The Authors |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-11 2022-11-01T00:00:00Z 2023-06-15T22:20:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/153980 |
url |
http://hdl.handle.net/10362/153980 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0261-5614 PURE: 63726633 https://doi.org/10.1016/j.clnu.2022.09.002 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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12 application/pdf |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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