Allergen immunotherapy in MASK-air users in real-life

Detalhes bibliográficos
Autor(a) principal: Sousa-Pinto, Bernardo
Data de Publicação: 2022
Outros Autores: Azevedo, Luís Filipe, Sá-Sousa, Ana, Vieira, Rafael José, Amaral, Rita, Klimek, Ludger, Czarlewski, Wienczyslawa, Anto, Josep M., Bedbrook, Anna, Kvedariene, Violeta, Ventura, Maria Teresa, Ansotegui, Ignacio J., Bergmann, Karl Christian, Brussino, Luisa, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Thomas, Cecchi, Lorenzo, Chivato, Tomás, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A., De Feo, Giulia, Devillier, Philippe, Fokkens, Wytske J., Gaga, Mina, Gemicioğlu, Bilun, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor, Kraxner, Helga, Larenas-Linnemann, Désirée E., Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michaël, Monti, Riccardo, Morais-Almeida, Mario, Mösges, Ralph, Mullol, Joaquim, Odemyr, Mikaëla, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham-Thi, Nhân, Regateiro, Frederico S., Reitsma, Sietze, Rouadi, Philip W., Samolinski, Boleslaw, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, João Almeida, Bousquet, Jean, Pfaar, Oliver
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/136401
Resumo: Funding Information: MASK-air has been supported by Charit? Universit?tsmedizin Berlin, EU Grants (EU Structural and Development Funds, POLLAR: EIT Health POLLAR, EIT Health Twinning) and educational grants from Mylan-Viatris, ALK, GSK, Novartis and Uriach. Open access funding enabled and organized by Projekt DEAL. Publisher Copyright: © 2022 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.
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spelling Allergen immunotherapy in MASK-air users in real-lifeResults of a Bayesian mixed-effects modelallergic rhinitisimmunotherapymobile healthpatient-reported outcomesreal-life data analysisImmunology and AllergyImmunologyPulmonary and Respiratory MedicineFunding Information: MASK-air has been supported by Charit? Universit?tsmedizin Berlin, EU Grants (EU Structural and Development Funds, POLLAR: EIT Health POLLAR, EIT Health Twinning) and educational grants from Mylan-Viatris, ALK, GSK, Novartis and Uriach. Open access funding enabled and organized by Projekt DEAL. Publisher Copyright: © 2022 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.Background: Evidence regarding the effectiveness of allergen immunotherapy (AIT) on allergic rhinitis has been provided mostly by randomised controlled trials, with little data from real-life studies. Objective: To compare the reported control of allergic rhinitis symptoms in three groups of users of the MASK-air® app: those receiving sublingual AIT (SLIT), those receiving subcutaneous AIT (SCIT), and those receiving no AIT. Methods: We assessed the MASK-air® data of European users with self-reported grass pollen allergy, comparing the data reported by patients receiving SLIT, SCIT and no AIT. Outcome variables included the daily impact of allergy symptoms globally and on work (measured by visual analogue scales—VASs), and a combined symptom-medication score (CSMS). We applied Bayesian mixed-effects models, with clustering by patient, country and pollen season. Results: We analysed a total of 42,756 days from 1,093 grass allergy patients, including 18,479 days of users under AIT. Compared to no AIT, SCIT was associated with similar VAS levels and CSMS. Compared to no AIT, SLIT-tablet was associated with lower values of VAS global allergy symptoms (average difference = 7.5 units out of 100; 95% credible interval [95%CrI] = −12.1;−2.8), lower VAS Work (average difference = 5.0; 95%CrI = −8.5;−1.5), and a lower CSMS (average difference = 3.7; 95%CrI = −9.3;2.2). When compared to SCIT, SLIT-tablet was associated with lower VAS global allergy symptoms (average difference = 10.2; 95%CrI = −17.2;−2.8), lower VAS Work (average difference = 7.8; 95%CrI = −15.1;0.2), and a lower CSMS (average difference = 9.3; 95%CrI = −18.5;0.2). Conclusion: In patients with grass pollen allergy, SLIT-tablet, when compared to no AIT and to SCIT, is associated with lower reported symptom severity. Future longitudinal studies following internationally-harmonised standards for performing and reporting real-world data in AIT are needed to better understand its ‘real-world’ effectiveness.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSRUNSousa-Pinto, BernardoAzevedo, Luís FilipeSá-Sousa, AnaVieira, Rafael JoséAmaral, RitaKlimek, LudgerCzarlewski, WienczyslawaAnto, Josep M.Bedbrook, AnnaKvedariene, VioletaVentura, Maria TeresaAnsotegui, Ignacio J.Bergmann, Karl ChristianBrussino, LuisaCanonica, G. WalterCardona, VictoriaCarreiro-Martins, PedroCasale, ThomasCecchi, LorenzoChivato, TomásChu, Derek K.Cingi, CemalCosta, Elisio M.Cruz, Alvaro A.De Feo, GiuliaDevillier, PhilippeFokkens, Wytske J.Gaga, MinaGemicioğlu, BilunHaahtela, TariIvancevich, Juan CarlosIspayeva, ZhanatJutel, MarekKuna, PiotrKaidashev, IgorKraxner, HelgaLarenas-Linnemann, Désirée E.Laune, DanielLipworth, BrianLouis, RenaudMakris, MichaëlMonti, RiccardoMorais-Almeida, MarioMösges, RalphMullol, JoaquimOdemyr, MikaëlaOkamoto, YoshitakaPapadopoulos, Nikolaos G.Patella, VincenzoPham-Thi, NhânRegateiro, Frederico S.Reitsma, SietzeRouadi, Philip W.Samolinski, BoleslawSova, MilanTodo-Bom, AnaTaborda-Barata, LuisTomazic, Peter ValentinToppila-Salmi, SannaSastre, JoaquinTsiligianni, IoannaValiulis, ArunasWallace, DanaWaserman, SusanYorgancioglu, ArzuZidarn, MihaelaZuberbier, TorstenFonseca, João AlmeidaBousquet, JeanPfaar, Oliver2022-04-13T22:43:40Z2022-032022-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/136401eng2045-7022PURE: 43145970https://doi.org/10.1002/clt2.12128info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:14:34Zoai:run.unl.pt:10362/136401Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:48:43.070345Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Allergen immunotherapy in MASK-air users in real-life
Results of a Bayesian mixed-effects model
title Allergen immunotherapy in MASK-air users in real-life
spellingShingle Allergen immunotherapy in MASK-air users in real-life
Sousa-Pinto, Bernardo
allergic rhinitis
immunotherapy
mobile health
patient-reported outcomes
real-life data analysis
Immunology and Allergy
Immunology
Pulmonary and Respiratory Medicine
title_short Allergen immunotherapy in MASK-air users in real-life
title_full Allergen immunotherapy in MASK-air users in real-life
title_fullStr Allergen immunotherapy in MASK-air users in real-life
title_full_unstemmed Allergen immunotherapy in MASK-air users in real-life
title_sort Allergen immunotherapy in MASK-air users in real-life
author Sousa-Pinto, Bernardo
author_facet Sousa-Pinto, Bernardo
Azevedo, Luís Filipe
Sá-Sousa, Ana
Vieira, Rafael José
Amaral, Rita
Klimek, Ludger
Czarlewski, Wienczyslawa
Anto, Josep M.
Bedbrook, Anna
Kvedariene, Violeta
Ventura, Maria Teresa
Ansotegui, Ignacio J.
Bergmann, Karl Christian
Brussino, Luisa
Canonica, G. Walter
Cardona, Victoria
Carreiro-Martins, Pedro
Casale, Thomas
Cecchi, Lorenzo
Chivato, Tomás
Chu, Derek K.
Cingi, Cemal
Costa, Elisio M.
Cruz, Alvaro A.
De Feo, Giulia
Devillier, Philippe
Fokkens, Wytske J.
Gaga, Mina
Gemicioğlu, Bilun
Haahtela, Tari
Ivancevich, Juan Carlos
Ispayeva, Zhanat
Jutel, Marek
Kuna, Piotr
Kaidashev, Igor
Kraxner, Helga
Larenas-Linnemann, Désirée E.
Laune, Daniel
Lipworth, Brian
Louis, Renaud
Makris, Michaël
Monti, Riccardo
Morais-Almeida, Mario
Mösges, Ralph
Mullol, Joaquim
Odemyr, Mikaëla
Okamoto, Yoshitaka
Papadopoulos, Nikolaos G.
Patella, Vincenzo
Pham-Thi, Nhân
Regateiro, Frederico S.
Reitsma, Sietze
Rouadi, Philip W.
Samolinski, Boleslaw
Sova, Milan
Todo-Bom, Ana
Taborda-Barata, Luis
Tomazic, Peter Valentin
Toppila-Salmi, Sanna
Sastre, Joaquin
Tsiligianni, Ioanna
Valiulis, Arunas
Wallace, Dana
Waserman, Susan
Yorgancioglu, Arzu
Zidarn, Mihaela
Zuberbier, Torsten
Fonseca, João Almeida
Bousquet, Jean
Pfaar, Oliver
author_role author
author2 Azevedo, Luís Filipe
Sá-Sousa, Ana
Vieira, Rafael José
Amaral, Rita
Klimek, Ludger
Czarlewski, Wienczyslawa
Anto, Josep M.
Bedbrook, Anna
Kvedariene, Violeta
Ventura, Maria Teresa
Ansotegui, Ignacio J.
Bergmann, Karl Christian
Brussino, Luisa
Canonica, G. Walter
Cardona, Victoria
Carreiro-Martins, Pedro
Casale, Thomas
Cecchi, Lorenzo
Chivato, Tomás
Chu, Derek K.
Cingi, Cemal
Costa, Elisio M.
Cruz, Alvaro A.
De Feo, Giulia
Devillier, Philippe
Fokkens, Wytske J.
Gaga, Mina
Gemicioğlu, Bilun
Haahtela, Tari
Ivancevich, Juan Carlos
Ispayeva, Zhanat
Jutel, Marek
Kuna, Piotr
Kaidashev, Igor
Kraxner, Helga
Larenas-Linnemann, Désirée E.
Laune, Daniel
Lipworth, Brian
Louis, Renaud
Makris, Michaël
Monti, Riccardo
Morais-Almeida, Mario
Mösges, Ralph
Mullol, Joaquim
Odemyr, Mikaëla
Okamoto, Yoshitaka
Papadopoulos, Nikolaos G.
Patella, Vincenzo
Pham-Thi, Nhân
Regateiro, Frederico S.
Reitsma, Sietze
Rouadi, Philip W.
Samolinski, Boleslaw
Sova, Milan
Todo-Bom, Ana
Taborda-Barata, Luis
Tomazic, Peter Valentin
Toppila-Salmi, Sanna
Sastre, Joaquin
Tsiligianni, Ioanna
Valiulis, Arunas
Wallace, Dana
Waserman, Susan
Yorgancioglu, Arzu
Zidarn, Mihaela
Zuberbier, Torsten
Fonseca, João Almeida
Bousquet, Jean
Pfaar, Oliver
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dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Comprehensive Health Research Centre (CHRC) - pólo NMS
RUN
dc.contributor.author.fl_str_mv Sousa-Pinto, Bernardo
Azevedo, Luís Filipe
Sá-Sousa, Ana
Vieira, Rafael José
Amaral, Rita
Klimek, Ludger
Czarlewski, Wienczyslawa
Anto, Josep M.
Bedbrook, Anna
Kvedariene, Violeta
Ventura, Maria Teresa
Ansotegui, Ignacio J.
Bergmann, Karl Christian
Brussino, Luisa
Canonica, G. Walter
Cardona, Victoria
Carreiro-Martins, Pedro
Casale, Thomas
Cecchi, Lorenzo
Chivato, Tomás
Chu, Derek K.
Cingi, Cemal
Costa, Elisio M.
Cruz, Alvaro A.
De Feo, Giulia
Devillier, Philippe
Fokkens, Wytske J.
Gaga, Mina
Gemicioğlu, Bilun
Haahtela, Tari
Ivancevich, Juan Carlos
Ispayeva, Zhanat
Jutel, Marek
Kuna, Piotr
Kaidashev, Igor
Kraxner, Helga
Larenas-Linnemann, Désirée E.
Laune, Daniel
Lipworth, Brian
Louis, Renaud
Makris, Michaël
Monti, Riccardo
Morais-Almeida, Mario
Mösges, Ralph
Mullol, Joaquim
Odemyr, Mikaëla
Okamoto, Yoshitaka
Papadopoulos, Nikolaos G.
Patella, Vincenzo
Pham-Thi, Nhân
Regateiro, Frederico S.
Reitsma, Sietze
Rouadi, Philip W.
Samolinski, Boleslaw
Sova, Milan
Todo-Bom, Ana
Taborda-Barata, Luis
Tomazic, Peter Valentin
Toppila-Salmi, Sanna
Sastre, Joaquin
Tsiligianni, Ioanna
Valiulis, Arunas
Wallace, Dana
Waserman, Susan
Yorgancioglu, Arzu
Zidarn, Mihaela
Zuberbier, Torsten
Fonseca, João Almeida
Bousquet, Jean
Pfaar, Oliver
dc.subject.por.fl_str_mv allergic rhinitis
immunotherapy
mobile health
patient-reported outcomes
real-life data analysis
Immunology and Allergy
Immunology
Pulmonary and Respiratory Medicine
topic allergic rhinitis
immunotherapy
mobile health
patient-reported outcomes
real-life data analysis
Immunology and Allergy
Immunology
Pulmonary and Respiratory Medicine
description Funding Information: MASK-air has been supported by Charit? Universit?tsmedizin Berlin, EU Grants (EU Structural and Development Funds, POLLAR: EIT Health POLLAR, EIT Health Twinning) and educational grants from Mylan-Viatris, ALK, GSK, Novartis and Uriach. Open access funding enabled and organized by Projekt DEAL. Publisher Copyright: © 2022 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.
publishDate 2022
dc.date.none.fl_str_mv 2022-04-13T22:43:40Z
2022-03
2022-03-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/136401
url http://hdl.handle.net/10362/136401
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2045-7022
PURE: 43145970
https://doi.org/10.1002/clt2.12128
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eu_rights_str_mv openAccess
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