Allergen immunotherapy in MASK-air users in real-life
| Autor(a) principal: | |
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| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/136401 |
Resumo: | Funding Information: MASK-air has been supported by Charit? Universit?tsmedizin Berlin, EU Grants (EU Structural and Development Funds, POLLAR: EIT Health POLLAR, EIT Health Twinning) and educational grants from Mylan-Viatris, ALK, GSK, Novartis and Uriach. Open access funding enabled and organized by Projekt DEAL. Publisher Copyright: © 2022 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology. |
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Allergen immunotherapy in MASK-air users in real-lifeResults of a Bayesian mixed-effects modelallergic rhinitisimmunotherapymobile healthpatient-reported outcomesreal-life data analysisImmunology and AllergyImmunologyPulmonary and Respiratory MedicineFunding Information: MASK-air has been supported by Charit? Universit?tsmedizin Berlin, EU Grants (EU Structural and Development Funds, POLLAR: EIT Health POLLAR, EIT Health Twinning) and educational grants from Mylan-Viatris, ALK, GSK, Novartis and Uriach. Open access funding enabled and organized by Projekt DEAL. Publisher Copyright: © 2022 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.Background: Evidence regarding the effectiveness of allergen immunotherapy (AIT) on allergic rhinitis has been provided mostly by randomised controlled trials, with little data from real-life studies. Objective: To compare the reported control of allergic rhinitis symptoms in three groups of users of the MASK-air® app: those receiving sublingual AIT (SLIT), those receiving subcutaneous AIT (SCIT), and those receiving no AIT. Methods: We assessed the MASK-air® data of European users with self-reported grass pollen allergy, comparing the data reported by patients receiving SLIT, SCIT and no AIT. Outcome variables included the daily impact of allergy symptoms globally and on work (measured by visual analogue scales—VASs), and a combined symptom-medication score (CSMS). We applied Bayesian mixed-effects models, with clustering by patient, country and pollen season. Results: We analysed a total of 42,756 days from 1,093 grass allergy patients, including 18,479 days of users under AIT. Compared to no AIT, SCIT was associated with similar VAS levels and CSMS. Compared to no AIT, SLIT-tablet was associated with lower values of VAS global allergy symptoms (average difference = 7.5 units out of 100; 95% credible interval [95%CrI] = −12.1;−2.8), lower VAS Work (average difference = 5.0; 95%CrI = −8.5;−1.5), and a lower CSMS (average difference = 3.7; 95%CrI = −9.3;2.2). When compared to SCIT, SLIT-tablet was associated with lower VAS global allergy symptoms (average difference = 10.2; 95%CrI = −17.2;−2.8), lower VAS Work (average difference = 7.8; 95%CrI = −15.1;0.2), and a lower CSMS (average difference = 9.3; 95%CrI = −18.5;0.2). Conclusion: In patients with grass pollen allergy, SLIT-tablet, when compared to no AIT and to SCIT, is associated with lower reported symptom severity. Future longitudinal studies following internationally-harmonised standards for performing and reporting real-world data in AIT are needed to better understand its ‘real-world’ effectiveness.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSRUNSousa-Pinto, BernardoAzevedo, Luís FilipeSá-Sousa, AnaVieira, Rafael JoséAmaral, RitaKlimek, LudgerCzarlewski, WienczyslawaAnto, Josep M.Bedbrook, AnnaKvedariene, VioletaVentura, Maria TeresaAnsotegui, Ignacio J.Bergmann, Karl ChristianBrussino, LuisaCanonica, G. WalterCardona, VictoriaCarreiro-Martins, PedroCasale, ThomasCecchi, LorenzoChivato, TomásChu, Derek K.Cingi, CemalCosta, Elisio M.Cruz, Alvaro A.De Feo, GiuliaDevillier, PhilippeFokkens, Wytske J.Gaga, MinaGemicioğlu, BilunHaahtela, TariIvancevich, Juan CarlosIspayeva, ZhanatJutel, MarekKuna, PiotrKaidashev, IgorKraxner, HelgaLarenas-Linnemann, Désirée E.Laune, DanielLipworth, BrianLouis, RenaudMakris, MichaëlMonti, RiccardoMorais-Almeida, MarioMösges, RalphMullol, JoaquimOdemyr, MikaëlaOkamoto, YoshitakaPapadopoulos, Nikolaos G.Patella, VincenzoPham-Thi, NhânRegateiro, Frederico S.Reitsma, SietzeRouadi, Philip W.Samolinski, BoleslawSova, MilanTodo-Bom, AnaTaborda-Barata, LuisTomazic, Peter ValentinToppila-Salmi, SannaSastre, JoaquinTsiligianni, IoannaValiulis, ArunasWallace, DanaWaserman, SusanYorgancioglu, ArzuZidarn, MihaelaZuberbier, TorstenFonseca, João AlmeidaBousquet, JeanPfaar, Oliver2022-04-13T22:43:40Z2022-032022-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/136401eng2045-7022PURE: 43145970https://doi.org/10.1002/clt2.12128info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:14:34Zoai:run.unl.pt:10362/136401Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:48:43.070345Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Allergen immunotherapy in MASK-air users in real-life Results of a Bayesian mixed-effects model |
| title |
Allergen immunotherapy in MASK-air users in real-life |
| spellingShingle |
Allergen immunotherapy in MASK-air users in real-life Sousa-Pinto, Bernardo allergic rhinitis immunotherapy mobile health patient-reported outcomes real-life data analysis Immunology and Allergy Immunology Pulmonary and Respiratory Medicine |
| title_short |
Allergen immunotherapy in MASK-air users in real-life |
| title_full |
Allergen immunotherapy in MASK-air users in real-life |
| title_fullStr |
Allergen immunotherapy in MASK-air users in real-life |
| title_full_unstemmed |
Allergen immunotherapy in MASK-air users in real-life |
| title_sort |
Allergen immunotherapy in MASK-air users in real-life |
| author |
Sousa-Pinto, Bernardo |
| author_facet |
Sousa-Pinto, Bernardo Azevedo, Luís Filipe Sá-Sousa, Ana Vieira, Rafael José Amaral, Rita Klimek, Ludger Czarlewski, Wienczyslawa Anto, Josep M. Bedbrook, Anna Kvedariene, Violeta Ventura, Maria Teresa Ansotegui, Ignacio J. Bergmann, Karl Christian Brussino, Luisa Canonica, G. Walter Cardona, Victoria Carreiro-Martins, Pedro Casale, Thomas Cecchi, Lorenzo Chivato, Tomás Chu, Derek K. Cingi, Cemal Costa, Elisio M. Cruz, Alvaro A. De Feo, Giulia Devillier, Philippe Fokkens, Wytske J. Gaga, Mina Gemicioğlu, Bilun Haahtela, Tari Ivancevich, Juan Carlos Ispayeva, Zhanat Jutel, Marek Kuna, Piotr Kaidashev, Igor Kraxner, Helga Larenas-Linnemann, Désirée E. Laune, Daniel Lipworth, Brian Louis, Renaud Makris, Michaël Monti, Riccardo Morais-Almeida, Mario Mösges, Ralph Mullol, Joaquim Odemyr, Mikaëla Okamoto, Yoshitaka Papadopoulos, Nikolaos G. Patella, Vincenzo Pham-Thi, Nhân Regateiro, Frederico S. Reitsma, Sietze Rouadi, Philip W. Samolinski, Boleslaw Sova, Milan Todo-Bom, Ana Taborda-Barata, Luis Tomazic, Peter Valentin Toppila-Salmi, Sanna Sastre, Joaquin Tsiligianni, Ioanna Valiulis, Arunas Wallace, Dana Waserman, Susan Yorgancioglu, Arzu Zidarn, Mihaela Zuberbier, Torsten Fonseca, João Almeida Bousquet, Jean Pfaar, Oliver |
| author_role |
author |
| author2 |
Azevedo, Luís Filipe Sá-Sousa, Ana Vieira, Rafael José Amaral, Rita Klimek, Ludger Czarlewski, Wienczyslawa Anto, Josep M. Bedbrook, Anna Kvedariene, Violeta Ventura, Maria Teresa Ansotegui, Ignacio J. Bergmann, Karl Christian Brussino, Luisa Canonica, G. Walter Cardona, Victoria Carreiro-Martins, Pedro Casale, Thomas Cecchi, Lorenzo Chivato, Tomás Chu, Derek K. Cingi, Cemal Costa, Elisio M. Cruz, Alvaro A. De Feo, Giulia Devillier, Philippe Fokkens, Wytske J. Gaga, Mina Gemicioğlu, Bilun Haahtela, Tari Ivancevich, Juan Carlos Ispayeva, Zhanat Jutel, Marek Kuna, Piotr Kaidashev, Igor Kraxner, Helga Larenas-Linnemann, Désirée E. Laune, Daniel Lipworth, Brian Louis, Renaud Makris, Michaël Monti, Riccardo Morais-Almeida, Mario Mösges, Ralph Mullol, Joaquim Odemyr, Mikaëla Okamoto, Yoshitaka Papadopoulos, Nikolaos G. Patella, Vincenzo Pham-Thi, Nhân Regateiro, Frederico S. Reitsma, Sietze Rouadi, Philip W. Samolinski, Boleslaw Sova, Milan Todo-Bom, Ana Taborda-Barata, Luis Tomazic, Peter Valentin Toppila-Salmi, Sanna Sastre, Joaquin Tsiligianni, Ioanna Valiulis, Arunas Wallace, Dana Waserman, Susan Yorgancioglu, Arzu Zidarn, Mihaela Zuberbier, Torsten Fonseca, João Almeida Bousquet, Jean Pfaar, Oliver |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Comprehensive Health Research Centre (CHRC) - pólo NMS RUN |
| dc.contributor.author.fl_str_mv |
Sousa-Pinto, Bernardo Azevedo, Luís Filipe Sá-Sousa, Ana Vieira, Rafael José Amaral, Rita Klimek, Ludger Czarlewski, Wienczyslawa Anto, Josep M. Bedbrook, Anna Kvedariene, Violeta Ventura, Maria Teresa Ansotegui, Ignacio J. Bergmann, Karl Christian Brussino, Luisa Canonica, G. Walter Cardona, Victoria Carreiro-Martins, Pedro Casale, Thomas Cecchi, Lorenzo Chivato, Tomás Chu, Derek K. Cingi, Cemal Costa, Elisio M. Cruz, Alvaro A. De Feo, Giulia Devillier, Philippe Fokkens, Wytske J. Gaga, Mina Gemicioğlu, Bilun Haahtela, Tari Ivancevich, Juan Carlos Ispayeva, Zhanat Jutel, Marek Kuna, Piotr Kaidashev, Igor Kraxner, Helga Larenas-Linnemann, Désirée E. Laune, Daniel Lipworth, Brian Louis, Renaud Makris, Michaël Monti, Riccardo Morais-Almeida, Mario Mösges, Ralph Mullol, Joaquim Odemyr, Mikaëla Okamoto, Yoshitaka Papadopoulos, Nikolaos G. Patella, Vincenzo Pham-Thi, Nhân Regateiro, Frederico S. Reitsma, Sietze Rouadi, Philip W. Samolinski, Boleslaw Sova, Milan Todo-Bom, Ana Taborda-Barata, Luis Tomazic, Peter Valentin Toppila-Salmi, Sanna Sastre, Joaquin Tsiligianni, Ioanna Valiulis, Arunas Wallace, Dana Waserman, Susan Yorgancioglu, Arzu Zidarn, Mihaela Zuberbier, Torsten Fonseca, João Almeida Bousquet, Jean Pfaar, Oliver |
| dc.subject.por.fl_str_mv |
allergic rhinitis immunotherapy mobile health patient-reported outcomes real-life data analysis Immunology and Allergy Immunology Pulmonary and Respiratory Medicine |
| topic |
allergic rhinitis immunotherapy mobile health patient-reported outcomes real-life data analysis Immunology and Allergy Immunology Pulmonary and Respiratory Medicine |
| description |
Funding Information: MASK-air has been supported by Charit? Universit?tsmedizin Berlin, EU Grants (EU Structural and Development Funds, POLLAR: EIT Health POLLAR, EIT Health Twinning) and educational grants from Mylan-Viatris, ALK, GSK, Novartis and Uriach. Open access funding enabled and organized by Projekt DEAL. Publisher Copyright: © 2022 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-04-13T22:43:40Z 2022-03 2022-03-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/136401 |
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eng |
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eng |
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2045-7022 PURE: 43145970 https://doi.org/10.1002/clt2.12128 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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