Fragaria vesca L. Extract: A Promising Cosmetic Ingredient with Antioxidant Properties
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/105531 https://doi.org/10.3390/antiox9020154 |
Resumo: | Fragaria vesca L. (F. vesca), popularly known as wild strawberry, is a plant from the Rosaceae family, found in temperate and subtropical areas of the northern hemisphere. F. vesca leaves have been shown to have antiseptic, emollient, and dermatological protection properties, due to the presence of bioactive compounds, such as flavonoids, phenolic acids, ellagitannins, and proanthocyanidins. In this study, a F. vesca extract was obtained by an optimized extraction process, and was characterized by HPLC, ROS scavenging activity, cytotoxicity assays in HaCaT cells, and tyrosinase inhibitory activity determination. The most active extract was then incorporated in a hydrogel with hydroxyethylcellulose at 2% (w/w), which was characterized at the physicochemical, stability, cytotoxicity, and ROS scavenging activity levels to evaluate its quality, safety, and efficacy. In vivo studies, human repeat insult patch testing, and an assay to determine their antioxidant efficacy, were also performed. The results showed that the Fragaria vesca extracts had antioxidant activity and that the F. vesca extract-based hydrogel exhibited cutaneous compatibility, acceptability and antioxidant efficacy, being stable, and suitable for topical application. |
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Fragaria vesca L. Extract: A Promising Cosmetic Ingredient with Antioxidant PropertiesFragaria vesca L.antioxidant propertieshydrogeltopical applicationcutaneous compatibilityFragaria vesca L. (F. vesca), popularly known as wild strawberry, is a plant from the Rosaceae family, found in temperate and subtropical areas of the northern hemisphere. F. vesca leaves have been shown to have antiseptic, emollient, and dermatological protection properties, due to the presence of bioactive compounds, such as flavonoids, phenolic acids, ellagitannins, and proanthocyanidins. In this study, a F. vesca extract was obtained by an optimized extraction process, and was characterized by HPLC, ROS scavenging activity, cytotoxicity assays in HaCaT cells, and tyrosinase inhibitory activity determination. The most active extract was then incorporated in a hydrogel with hydroxyethylcellulose at 2% (w/w), which was characterized at the physicochemical, stability, cytotoxicity, and ROS scavenging activity levels to evaluate its quality, safety, and efficacy. In vivo studies, human repeat insult patch testing, and an assay to determine their antioxidant efficacy, were also performed. The results showed that the Fragaria vesca extracts had antioxidant activity and that the F. vesca extract-based hydrogel exhibited cutaneous compatibility, acceptability and antioxidant efficacy, being stable, and suitable for topical application.MDPI2020-02-14info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/105531http://hdl.handle.net/10316/105531https://doi.org/10.3390/antiox9020154eng2076-3921Couto, JoanaFigueirinha, ArturBatista, Maria TeresaParanhos, AntónioNunes, CarlaGonçalves, Lídia MariaMarto, JoanaFitas, ManuelPinto, PedroRibeiro, Helena MargaridaPina, Maria Eugéniainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T10:58:43Zoai:estudogeral.uc.pt:10316/105531Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:22:05.659978Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Fragaria vesca L. Extract: A Promising Cosmetic Ingredient with Antioxidant Properties |
title |
Fragaria vesca L. Extract: A Promising Cosmetic Ingredient with Antioxidant Properties |
spellingShingle |
Fragaria vesca L. Extract: A Promising Cosmetic Ingredient with Antioxidant Properties Couto, Joana Fragaria vesca L. antioxidant properties hydrogel topical application cutaneous compatibility |
title_short |
Fragaria vesca L. Extract: A Promising Cosmetic Ingredient with Antioxidant Properties |
title_full |
Fragaria vesca L. Extract: A Promising Cosmetic Ingredient with Antioxidant Properties |
title_fullStr |
Fragaria vesca L. Extract: A Promising Cosmetic Ingredient with Antioxidant Properties |
title_full_unstemmed |
Fragaria vesca L. Extract: A Promising Cosmetic Ingredient with Antioxidant Properties |
title_sort |
Fragaria vesca L. Extract: A Promising Cosmetic Ingredient with Antioxidant Properties |
author |
Couto, Joana |
author_facet |
Couto, Joana Figueirinha, Artur Batista, Maria Teresa Paranhos, António Nunes, Carla Gonçalves, Lídia Maria Marto, Joana Fitas, Manuel Pinto, Pedro Ribeiro, Helena Margarida Pina, Maria Eugénia |
author_role |
author |
author2 |
Figueirinha, Artur Batista, Maria Teresa Paranhos, António Nunes, Carla Gonçalves, Lídia Maria Marto, Joana Fitas, Manuel Pinto, Pedro Ribeiro, Helena Margarida Pina, Maria Eugénia |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Couto, Joana Figueirinha, Artur Batista, Maria Teresa Paranhos, António Nunes, Carla Gonçalves, Lídia Maria Marto, Joana Fitas, Manuel Pinto, Pedro Ribeiro, Helena Margarida Pina, Maria Eugénia |
dc.subject.por.fl_str_mv |
Fragaria vesca L. antioxidant properties hydrogel topical application cutaneous compatibility |
topic |
Fragaria vesca L. antioxidant properties hydrogel topical application cutaneous compatibility |
description |
Fragaria vesca L. (F. vesca), popularly known as wild strawberry, is a plant from the Rosaceae family, found in temperate and subtropical areas of the northern hemisphere. F. vesca leaves have been shown to have antiseptic, emollient, and dermatological protection properties, due to the presence of bioactive compounds, such as flavonoids, phenolic acids, ellagitannins, and proanthocyanidins. In this study, a F. vesca extract was obtained by an optimized extraction process, and was characterized by HPLC, ROS scavenging activity, cytotoxicity assays in HaCaT cells, and tyrosinase inhibitory activity determination. The most active extract was then incorporated in a hydrogel with hydroxyethylcellulose at 2% (w/w), which was characterized at the physicochemical, stability, cytotoxicity, and ROS scavenging activity levels to evaluate its quality, safety, and efficacy. In vivo studies, human repeat insult patch testing, and an assay to determine their antioxidant efficacy, were also performed. The results showed that the Fragaria vesca extracts had antioxidant activity and that the F. vesca extract-based hydrogel exhibited cutaneous compatibility, acceptability and antioxidant efficacy, being stable, and suitable for topical application. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-02-14 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/105531 http://hdl.handle.net/10316/105531 https://doi.org/10.3390/antiox9020154 |
url |
http://hdl.handle.net/10316/105531 https://doi.org/10.3390/antiox9020154 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2076-3921 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134110874075136 |