Comparison of the frequency of interleukin (IL)-2-, interferon-γ-, and IL-4-producing T cells in 2 diseases, human immunodeficiency virus types 1 and 2, with distinct clinical outcomes

Detalhes bibliográficos
Autor(a) principal: Sousa, Ana E.
Data de Publicação: 2001
Outros Autores: Chaves, Ana F., Loureiro, Ana, Victorino, Rui M. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/18442
Resumo: © 2001 by the Infectious Diseases Society of America
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spelling Comparison of the frequency of interleukin (IL)-2-, interferon-γ-, and IL-4-producing T cells in 2 diseases, human immunodeficiency virus types 1 and 2, with distinct clinical outcomes© 2001 by the Infectious Diseases Society of AmericaHuman immunodeficiency virus (HIV) type 2 infection is associated with a better clinical outcome, slower rates of CD4 T cell decline, and lower viremia than is HIV-1. This study compares HIV-1 and HIV-2 in regard to the percentages of interleukin (IL)–2–, interferon (IFN)–γ–, and IL-4–producing cells at the single-cell level, as determined by flow cytometry. At a given degree of CD4 T cell depletion, the frequency of T cells able to produce IL-2 is better preserved in HIV-2 than in HIV-1 infection, particularly within the CD4 T cell subset. As described for HIV-1 immunodeficiency, HIV-2–positive patients exhibit a marked expansion of terminally differentiated effector CD8 T cells (CD28−CD27−IFN-γ+). However, the proportion of CD8 T cells able to simultaneously produce IL-2 and IFN-γ is higher in HIV-2 disease. Considering the central role of IL-2 as a lymphocyte proliferative and survival factor, these findings provide a possible immunologic basis for the distinct course of HIV-2 immunodeficiencyMinistério da Ciência e Tecnologia–Praxis XXI; Comissão Nacional de Luta Contra a SIDA (CNLCS)–Ministério da Saúde (to R.M.M.V.); Praxis (scholarships to A.E.S. and A.L.); CNLCS (scholarship to A.F.C.).Oxford University PressRepositório da Universidade de LisboaSousa, Ana E.Chaves, Ana F.Loureiro, AnaVictorino, Rui M. M.2015-07-14T15:05:04Z20012001-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/18442engThe Journal of Infectious Diseases 2001;184:552–90022-1899http://dx.doi.org/10.1086/322804metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:04:32Zoai:repositorio.ul.pt:10451/18442Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:37:54.563349Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Comparison of the frequency of interleukin (IL)-2-, interferon-γ-, and IL-4-producing T cells in 2 diseases, human immunodeficiency virus types 1 and 2, with distinct clinical outcomes
title Comparison of the frequency of interleukin (IL)-2-, interferon-γ-, and IL-4-producing T cells in 2 diseases, human immunodeficiency virus types 1 and 2, with distinct clinical outcomes
spellingShingle Comparison of the frequency of interleukin (IL)-2-, interferon-γ-, and IL-4-producing T cells in 2 diseases, human immunodeficiency virus types 1 and 2, with distinct clinical outcomes
Sousa, Ana E.
title_short Comparison of the frequency of interleukin (IL)-2-, interferon-γ-, and IL-4-producing T cells in 2 diseases, human immunodeficiency virus types 1 and 2, with distinct clinical outcomes
title_full Comparison of the frequency of interleukin (IL)-2-, interferon-γ-, and IL-4-producing T cells in 2 diseases, human immunodeficiency virus types 1 and 2, with distinct clinical outcomes
title_fullStr Comparison of the frequency of interleukin (IL)-2-, interferon-γ-, and IL-4-producing T cells in 2 diseases, human immunodeficiency virus types 1 and 2, with distinct clinical outcomes
title_full_unstemmed Comparison of the frequency of interleukin (IL)-2-, interferon-γ-, and IL-4-producing T cells in 2 diseases, human immunodeficiency virus types 1 and 2, with distinct clinical outcomes
title_sort Comparison of the frequency of interleukin (IL)-2-, interferon-γ-, and IL-4-producing T cells in 2 diseases, human immunodeficiency virus types 1 and 2, with distinct clinical outcomes
author Sousa, Ana E.
author_facet Sousa, Ana E.
Chaves, Ana F.
Loureiro, Ana
Victorino, Rui M. M.
author_role author
author2 Chaves, Ana F.
Loureiro, Ana
Victorino, Rui M. M.
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Sousa, Ana E.
Chaves, Ana F.
Loureiro, Ana
Victorino, Rui M. M.
description © 2001 by the Infectious Diseases Society of America
publishDate 2001
dc.date.none.fl_str_mv 2001
2001-01-01T00:00:00Z
2015-07-14T15:05:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/18442
url http://hdl.handle.net/10451/18442
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv The Journal of Infectious Diseases 2001;184:552–9
0022-1899
http://dx.doi.org/10.1086/322804
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rights_invalid_str_mv metadata only access
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dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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