Pathway-guided monitoring of the disease course in bladder cancer with longitudinal urine proteomics
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/158383 |
Resumo: | PM003/2016). H.López-Fernández is supported by a ‘María Zambrano’ post-doctoral contract from Ministerio de Universidades (Gobierno de España). |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Pathway-guided monitoring of the disease course in bladder cancer with longitudinal urine proteomicsSDG 3 - Good Health and Well-beingPM003/2016). H.López-Fernández is supported by a ‘María Zambrano’ post-doctoral contract from Ministerio de Universidades (Gobierno de España).Background Monitoring bladder cancer over time requires invasive and costly procedures. Less invasive approaches are required using readily available biological samples such as urine. In this study, we demonstrate a method for longitudinal analysis of the urine proteome to monitor the disease course in patients with bladder cancer. Methods We compared the urine proteomes of patients who experienced recurrence and/or progression (n = 13) with those who did not (n = 17). We identified differentially expressed proteins within various pathways related to the hallmarks of cancer. The variation of such pathways during the disease course was determined using our differential personal pathway index (dPPi) calculation, which could indicate disease progression and the need for medical intervention. Results Seven hallmark pathways are used to develop the dPPi. We demonstrate that we can successfully longitudinally monitor the disease course in bladder cancer patients through a combination of urine proteomic analysis and the dPPi calculation, over a period of 62 months. Conclusions Using the information contained in the patient’s urinary proteome, the dPPi reflects the individual’s course of bladder cancer, and helps to optimise the use of more invasive procedures such as cystoscopy.DQ - Departamento de QuímicaLAQV@REQUIMTENOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNCarvalho, Luís BotelhoCapelo, José LuísLodeiro, CarlosDhir, RajivPinheiro, Luís CamposLopez-Fernandez, HugoMartins, GonçaloMedeiros, MarianaDíaz, FernandoSantos, Hugo Miguel2023-09-27T22:26:06Z2023-01-162023-01-16T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10application/pdfhttp://hdl.handle.net/10362/158383eng2730-664xPURE: 72500471https://doi.org/10.1038/s43856-023-00238-4info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:40:44Zoai:run.unl.pt:10362/158383Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:06.495108Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Pathway-guided monitoring of the disease course in bladder cancer with longitudinal urine proteomics |
| title |
Pathway-guided monitoring of the disease course in bladder cancer with longitudinal urine proteomics |
| spellingShingle |
Pathway-guided monitoring of the disease course in bladder cancer with longitudinal urine proteomics Carvalho, Luís Botelho SDG 3 - Good Health and Well-being |
| title_short |
Pathway-guided monitoring of the disease course in bladder cancer with longitudinal urine proteomics |
| title_full |
Pathway-guided monitoring of the disease course in bladder cancer with longitudinal urine proteomics |
| title_fullStr |
Pathway-guided monitoring of the disease course in bladder cancer with longitudinal urine proteomics |
| title_full_unstemmed |
Pathway-guided monitoring of the disease course in bladder cancer with longitudinal urine proteomics |
| title_sort |
Pathway-guided monitoring of the disease course in bladder cancer with longitudinal urine proteomics |
| author |
Carvalho, Luís Botelho |
| author_facet |
Carvalho, Luís Botelho Capelo, José Luís Lodeiro, Carlos Dhir, Rajiv Pinheiro, Luís Campos Lopez-Fernandez, Hugo Martins, Gonçalo Medeiros, Mariana Díaz, Fernando Santos, Hugo Miguel |
| author_role |
author |
| author2 |
Capelo, José Luís Lodeiro, Carlos Dhir, Rajiv Pinheiro, Luís Campos Lopez-Fernandez, Hugo Martins, Gonçalo Medeiros, Mariana Díaz, Fernando Santos, Hugo Miguel |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
DQ - Departamento de Química LAQV@REQUIMTE NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Carvalho, Luís Botelho Capelo, José Luís Lodeiro, Carlos Dhir, Rajiv Pinheiro, Luís Campos Lopez-Fernandez, Hugo Martins, Gonçalo Medeiros, Mariana Díaz, Fernando Santos, Hugo Miguel |
| dc.subject.por.fl_str_mv |
SDG 3 - Good Health and Well-being |
| topic |
SDG 3 - Good Health and Well-being |
| description |
PM003/2016). H.López-Fernández is supported by a ‘María Zambrano’ post-doctoral contract from Ministerio de Universidades (Gobierno de España). |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-09-27T22:26:06Z 2023-01-16 2023-01-16T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/158383 |
| url |
http://hdl.handle.net/10362/158383 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2730-664x PURE: 72500471 https://doi.org/10.1038/s43856-023-00238-4 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
| dc.format.none.fl_str_mv |
10 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799138154470440960 |