Study of iron and copper metabolism in Alzheimer\2019s disease

Detalhes bibliográficos
Autor(a) principal: Crespo, Ângela Pascoal da Costa
Data de Publicação: 2009
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/1801
Resumo: Tese de mestrado, Biologia (Biologia Molecular humana), 2009, Universidade de Lisboa, Faculdade de Ciências
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spelling Study of iron and copper metabolism in Alzheimer\2019s diseaseBiologia celularDoença de AlzheimerStress oxidativoMarcadores biológicosTeses de mestradoTese de mestrado, Biologia (Biologia Molecular humana), 2009, Universidade de Lisboa, Faculdade de CiênciasAlzheimer's disease (AD) is the most frequent neurodegenerative disorder worldwide, remarkably characterized by memory impairment. The distinction between normal aging and AD is a relevant step to combat this disease efficiently; thus, the identification of biomarkers and genetic factors underlying AD pathology is extremely important. Oxidative injury in the brain, mediated by the imbalance of redox-active metals, iron (Fe) and copper (Cu), has been recognized to contribute to the pathology of AD. In this context, we further investigated this hypothesis by: (I) comparing serum biochemical markers of Fe/Cu metabolism in a sample of 73 AD patients and 60 healthy controls; (II) testing, in the same sample, a set of Fe/Cu metabolism-related genes and APOE for association with AD. Significant differences were found between female AD patients and controls for serum Fe concentration (71.02 ± 22.34 µg/dL and 86.38 ± 20.80 µg/dL, respectively, p=0.001) and transferrin saturation (22.29 ± 7.89 % and 26.21 ± 6.24 %, respectively, p=0.007). A significant association with AD was found for TF transferrin gene (p=0.0082) and for the first time for SLC40A1 ferroportin (Fpn) gene (p=0.0355). APOEε4 was also significantly associated with AD (p=0.0004), in agreement with previous studies. We hypothesize that the lower serum Fe concentration observed in AD patients can be due to impaired Fe excretion from cells, since Fpn is the only known Fe exporter in mammalian cells. The intracellular accumulation of Fe, particularly in the brain, where Fpn is also expressed, would lead to a rise in oxidative damage, contributing to the AD physiopathology. Further research is demanded in a greater sample to confirm the results obtained in this pilot study. Noteworthy, an integrative approach was followed to deal with heterogeneity in this complex disorder, and new directions were raised related to the study of the involvement of Fe metabolism in AD.Resumo alargado em português disponível no documentoGomes, Manuel do CarmoCosta, Luciana Maria Gonçalves daRepositório da Universidade de LisboaCrespo, Ângela Pascoal da Costa2010-07-28T16:13:15Z20092009-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfapplication/pdftext/xmlhttp://hdl.handle.net/10451/1801enghttp://catalogo.ul.pt/F/?func=item-global&doc_library=ULB01&type=03&doc_number=000576657info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T15:41:46Zoai:repositorio.ul.pt:10451/1801Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:28:21.916576Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Study of iron and copper metabolism in Alzheimer\2019s disease
title Study of iron and copper metabolism in Alzheimer\2019s disease
spellingShingle Study of iron and copper metabolism in Alzheimer\2019s disease
Crespo, Ângela Pascoal da Costa
Biologia celular
Doença de Alzheimer
Stress oxidativo
Marcadores biológicos
Teses de mestrado
title_short Study of iron and copper metabolism in Alzheimer\2019s disease
title_full Study of iron and copper metabolism in Alzheimer\2019s disease
title_fullStr Study of iron and copper metabolism in Alzheimer\2019s disease
title_full_unstemmed Study of iron and copper metabolism in Alzheimer\2019s disease
title_sort Study of iron and copper metabolism in Alzheimer\2019s disease
author Crespo, Ângela Pascoal da Costa
author_facet Crespo, Ângela Pascoal da Costa
author_role author
dc.contributor.none.fl_str_mv Gomes, Manuel do Carmo
Costa, Luciana Maria Gonçalves da
Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Crespo, Ângela Pascoal da Costa
dc.subject.por.fl_str_mv Biologia celular
Doença de Alzheimer
Stress oxidativo
Marcadores biológicos
Teses de mestrado
topic Biologia celular
Doença de Alzheimer
Stress oxidativo
Marcadores biológicos
Teses de mestrado
description Tese de mestrado, Biologia (Biologia Molecular humana), 2009, Universidade de Lisboa, Faculdade de Ciências
publishDate 2009
dc.date.none.fl_str_mv 2009
2009-01-01T00:00:00Z
2010-07-28T16:13:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/1801
url http://hdl.handle.net/10451/1801
dc.language.iso.fl_str_mv eng
language eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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