Study of iron and copper metabolism in Alzheimer\2019s disease
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Data de Publicação: | 2009 |
Tipo de documento: | Dissertação |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/1801 |
Resumo: | Tese de mestrado, Biologia (Biologia Molecular humana), 2009, Universidade de Lisboa, Faculdade de Ciências |
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Study of iron and copper metabolism in Alzheimer\2019s diseaseBiologia celularDoença de AlzheimerStress oxidativoMarcadores biológicosTeses de mestradoTese de mestrado, Biologia (Biologia Molecular humana), 2009, Universidade de Lisboa, Faculdade de CiênciasAlzheimer's disease (AD) is the most frequent neurodegenerative disorder worldwide, remarkably characterized by memory impairment. The distinction between normal aging and AD is a relevant step to combat this disease efficiently; thus, the identification of biomarkers and genetic factors underlying AD pathology is extremely important. Oxidative injury in the brain, mediated by the imbalance of redox-active metals, iron (Fe) and copper (Cu), has been recognized to contribute to the pathology of AD. In this context, we further investigated this hypothesis by: (I) comparing serum biochemical markers of Fe/Cu metabolism in a sample of 73 AD patients and 60 healthy controls; (II) testing, in the same sample, a set of Fe/Cu metabolism-related genes and APOE for association with AD. Significant differences were found between female AD patients and controls for serum Fe concentration (71.02 ± 22.34 µg/dL and 86.38 ± 20.80 µg/dL, respectively, p=0.001) and transferrin saturation (22.29 ± 7.89 % and 26.21 ± 6.24 %, respectively, p=0.007). A significant association with AD was found for TF transferrin gene (p=0.0082) and for the first time for SLC40A1 ferroportin (Fpn) gene (p=0.0355). APOEε4 was also significantly associated with AD (p=0.0004), in agreement with previous studies. We hypothesize that the lower serum Fe concentration observed in AD patients can be due to impaired Fe excretion from cells, since Fpn is the only known Fe exporter in mammalian cells. The intracellular accumulation of Fe, particularly in the brain, where Fpn is also expressed, would lead to a rise in oxidative damage, contributing to the AD physiopathology. Further research is demanded in a greater sample to confirm the results obtained in this pilot study. Noteworthy, an integrative approach was followed to deal with heterogeneity in this complex disorder, and new directions were raised related to the study of the involvement of Fe metabolism in AD.Resumo alargado em português disponível no documentoGomes, Manuel do CarmoCosta, Luciana Maria Gonçalves daRepositório da Universidade de LisboaCrespo, Ângela Pascoal da Costa2010-07-28T16:13:15Z20092009-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfapplication/pdftext/xmlhttp://hdl.handle.net/10451/1801enghttp://catalogo.ul.pt/F/?func=item-global&doc_library=ULB01&type=03&doc_number=000576657info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T15:41:46Zoai:repositorio.ul.pt:10451/1801Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:28:21.916576Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Study of iron and copper metabolism in Alzheimer\2019s disease |
title |
Study of iron and copper metabolism in Alzheimer\2019s disease |
spellingShingle |
Study of iron and copper metabolism in Alzheimer\2019s disease Crespo, Ângela Pascoal da Costa Biologia celular Doença de Alzheimer Stress oxidativo Marcadores biológicos Teses de mestrado |
title_short |
Study of iron and copper metabolism in Alzheimer\2019s disease |
title_full |
Study of iron and copper metabolism in Alzheimer\2019s disease |
title_fullStr |
Study of iron and copper metabolism in Alzheimer\2019s disease |
title_full_unstemmed |
Study of iron and copper metabolism in Alzheimer\2019s disease |
title_sort |
Study of iron and copper metabolism in Alzheimer\2019s disease |
author |
Crespo, Ângela Pascoal da Costa |
author_facet |
Crespo, Ângela Pascoal da Costa |
author_role |
author |
dc.contributor.none.fl_str_mv |
Gomes, Manuel do Carmo Costa, Luciana Maria Gonçalves da Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Crespo, Ângela Pascoal da Costa |
dc.subject.por.fl_str_mv |
Biologia celular Doença de Alzheimer Stress oxidativo Marcadores biológicos Teses de mestrado |
topic |
Biologia celular Doença de Alzheimer Stress oxidativo Marcadores biológicos Teses de mestrado |
description |
Tese de mestrado, Biologia (Biologia Molecular humana), 2009, Universidade de Lisboa, Faculdade de Ciências |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009 2009-01-01T00:00:00Z 2010-07-28T16:13:15Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/1801 |
url |
http://hdl.handle.net/10451/1801 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://catalogo.ul.pt/F/?func=item-global&doc_library=ULB01&type=03&doc_number=000576657 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf text/xml |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134167501373440 |