Microfluidic paper-based device incorporated with silica nanoparticles for iodide quantification in marine source dietary supplements
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.14/43995 |
Resumo: | Iodine is an essential micronutrient for humans due to its fundamental role in the biosynthesis of thyroid hormones. As a key parameter to assess health conditions, iodine intake needs to be monitored to ascertain and prevent iodine deficiency. Iodine is available from various food sources (such as seaweed, fish, and seafood, among others) and dietary supplements (multivitamins or mineral supplements). In this work, a microfluidic paper-based analytical device (μPAD) to quantify iodide in seaweed and dietary supplements is described. The developed μPAD is a small microfluidic device that emerges as quite relevant in terms of its analytical capacity. The quantification of iodide is based on the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) by hydrogen peroxide in the presence of iodine, which acts as the catalyst to produce the blue form of TMB. Additionally, powder silica was used to intensify and uniformize the colour of the obtained product. Following optimization, the developed μPAD enabled iodide quantification within the range of 10–100 μM, with a detection limit of 3 μM, and was successfully applied to seaweeds and dietary supplements. The device represents a valuable tool for point-of-care analysis, can be used by untrained personnel at home, and is easily disposable, low-cost, and user-friendly. |
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Microfluidic paper-based device incorporated with silica nanoparticles for iodide quantification in marine source dietary supplementsIodide determinationµPADTMB reactionFood samplesDietary supplementsIodine is an essential micronutrient for humans due to its fundamental role in the biosynthesis of thyroid hormones. As a key parameter to assess health conditions, iodine intake needs to be monitored to ascertain and prevent iodine deficiency. Iodine is available from various food sources (such as seaweed, fish, and seafood, among others) and dietary supplements (multivitamins or mineral supplements). In this work, a microfluidic paper-based analytical device (μPAD) to quantify iodide in seaweed and dietary supplements is described. The developed μPAD is a small microfluidic device that emerges as quite relevant in terms of its analytical capacity. The quantification of iodide is based on the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) by hydrogen peroxide in the presence of iodine, which acts as the catalyst to produce the blue form of TMB. Additionally, powder silica was used to intensify and uniformize the colour of the obtained product. Following optimization, the developed μPAD enabled iodide quantification within the range of 10–100 μM, with a detection limit of 3 μM, and was successfully applied to seaweeds and dietary supplements. The device represents a valuable tool for point-of-care analysis, can be used by untrained personnel at home, and is easily disposable, low-cost, and user-friendly.Veritati - Repositório Institucional da Universidade Católica PortuguesaPereira, Mafalda G.Machado, AnaLeite, AndreiaRangel, MariaBordalo, AdrianoRangel, António O. S. S.Mesquita, Raquel B. R.2024-02-16T11:13:09Z2024-02-052024-02-05T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/43995eng1424-321010.3390/s24031024info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-20T01:33:07Zoai:repositorio.ucp.pt:10400.14/43995Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:39:02.930917Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Microfluidic paper-based device incorporated with silica nanoparticles for iodide quantification in marine source dietary supplements |
title |
Microfluidic paper-based device incorporated with silica nanoparticles for iodide quantification in marine source dietary supplements |
spellingShingle |
Microfluidic paper-based device incorporated with silica nanoparticles for iodide quantification in marine source dietary supplements Pereira, Mafalda G. Iodide determination µPAD TMB reaction Food samples Dietary supplements |
title_short |
Microfluidic paper-based device incorporated with silica nanoparticles for iodide quantification in marine source dietary supplements |
title_full |
Microfluidic paper-based device incorporated with silica nanoparticles for iodide quantification in marine source dietary supplements |
title_fullStr |
Microfluidic paper-based device incorporated with silica nanoparticles for iodide quantification in marine source dietary supplements |
title_full_unstemmed |
Microfluidic paper-based device incorporated with silica nanoparticles for iodide quantification in marine source dietary supplements |
title_sort |
Microfluidic paper-based device incorporated with silica nanoparticles for iodide quantification in marine source dietary supplements |
author |
Pereira, Mafalda G. |
author_facet |
Pereira, Mafalda G. Machado, Ana Leite, Andreia Rangel, Maria Bordalo, Adriano Rangel, António O. S. S. Mesquita, Raquel B. R. |
author_role |
author |
author2 |
Machado, Ana Leite, Andreia Rangel, Maria Bordalo, Adriano Rangel, António O. S. S. Mesquita, Raquel B. R. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Veritati - Repositório Institucional da Universidade Católica Portuguesa |
dc.contributor.author.fl_str_mv |
Pereira, Mafalda G. Machado, Ana Leite, Andreia Rangel, Maria Bordalo, Adriano Rangel, António O. S. S. Mesquita, Raquel B. R. |
dc.subject.por.fl_str_mv |
Iodide determination µPAD TMB reaction Food samples Dietary supplements |
topic |
Iodide determination µPAD TMB reaction Food samples Dietary supplements |
description |
Iodine is an essential micronutrient for humans due to its fundamental role in the biosynthesis of thyroid hormones. As a key parameter to assess health conditions, iodine intake needs to be monitored to ascertain and prevent iodine deficiency. Iodine is available from various food sources (such as seaweed, fish, and seafood, among others) and dietary supplements (multivitamins or mineral supplements). In this work, a microfluidic paper-based analytical device (μPAD) to quantify iodide in seaweed and dietary supplements is described. The developed μPAD is a small microfluidic device that emerges as quite relevant in terms of its analytical capacity. The quantification of iodide is based on the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) by hydrogen peroxide in the presence of iodine, which acts as the catalyst to produce the blue form of TMB. Additionally, powder silica was used to intensify and uniformize the colour of the obtained product. Following optimization, the developed μPAD enabled iodide quantification within the range of 10–100 μM, with a detection limit of 3 μM, and was successfully applied to seaweeds and dietary supplements. The device represents a valuable tool for point-of-care analysis, can be used by untrained personnel at home, and is easily disposable, low-cost, and user-friendly. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-02-16T11:13:09Z 2024-02-05 2024-02-05T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.14/43995 |
url |
http://hdl.handle.net/10400.14/43995 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1424-3210 10.3390/s24031024 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137440695320576 |