Sulfonyldibenzoate coordination polymers as bioactive dopants for polysaccharide films with antibacterial and antibiofilm properties
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/88509 |
Resumo: | This work describes the preparation, characterization, and antimicrobial properties of bioactive silver(I) and copper(II) coordination polymers (bioCPs) and derived biopolymer materials. Two bioCPs, [Ag2(6-sdba)]n (1) and [Cu(4-sdba)H2O]n·1.5nH2O (2), were assembled from metal salt precursors and 4,4-sulfonyldibenzoic acid (H2sdba). Both compounds were used as dopants for preparing hybrid biopolymer films based on agarose (AGR) or potato starch (PS) as model polysaccharide biopolymers with varying rates of degradability and silver/copper release. BioCPs and derived biopolymer films (1@[AGR]n, 2@[AGR]n, 1@[PS]n, and 2@[PS]n) with a low loading of dopant (15 wt%) show promising antibacterial activity against Gram-positive (S. aureus and S. epidermidis) and Gram-negative (E. coli and P. aeruginosa) bacteria. Silver-doped biopolymer films also totally impair the formation of bacterial biofilms, with undetectable biofilm cells in several cases (7.5log or 99.99999% inhibition). By reporting new bioCPs and biopolymer films obtained from renewable polysaccharides, this multidisciplinary work extends the application of coordination compounds as components of hybrid functional materials with antimicrobial properties and prospective biomedical relevance. |
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Sulfonyldibenzoate coordination polymers as bioactive dopants for polysaccharide films with antibacterial and antibiofilm propertiesThis work describes the preparation, characterization, and antimicrobial properties of bioactive silver(I) and copper(II) coordination polymers (bioCPs) and derived biopolymer materials. Two bioCPs, [Ag2(6-sdba)]n (1) and [Cu(4-sdba)H2O]n·1.5nH2O (2), were assembled from metal salt precursors and 4,4-sulfonyldibenzoic acid (H2sdba). Both compounds were used as dopants for preparing hybrid biopolymer films based on agarose (AGR) or potato starch (PS) as model polysaccharide biopolymers with varying rates of degradability and silver/copper release. BioCPs and derived biopolymer films (1@[AGR]n, 2@[AGR]n, 1@[PS]n, and 2@[PS]n) with a low loading of dopant (15 wt%) show promising antibacterial activity against Gram-positive (S. aureus and S. epidermidis) and Gram-negative (E. coli and P. aeruginosa) bacteria. Silver-doped biopolymer films also totally impair the formation of bacterial biofilms, with undetectable biofilm cells in several cases (7.5log or 99.99999% inhibition). By reporting new bioCPs and biopolymer films obtained from renewable polysaccharides, this multidisciplinary work extends the application of coordination compounds as components of hybrid functional materials with antimicrobial properties and prospective biomedical relevance.This study was supported by the Foundation for Science and Technology (FCT) (projects PTDC/QUI-QIN/3898/2020, PTDC/QUI-QIN/29697/2017, UIDP/00100/2020, UIDB/00100/2020, LA/P/0056/2020, and REM2013; contracts under DL No. 57/2016, CEECIND/02725/2018, CEECIND/00283/2018 and CEECIND/00194/2020) as well as ISEL (IPL/2022/3DBioProd_ISEL, and IPL/2021/Naf4Med3D_ISEL). We thank Dr. Ivo M. F. Bragança for studying the mechanical properties.info:eu-repo/semantics/publishedVersionRoyal Society of ChemistryUniversidade do MinhoFernandes, Tiago A.Macedo, FilipaCabral, Rafaela G.Guiu, TelmaFranco, Chris H. J.Jorge, PaulaSousa, Ana CatarinaAndré, VâniaCerca, NunoKirillov, Alexander M.20242024-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/88509engFernandes, T. A., Macedo, F., Cabral, R. G., Guiu, T., Franco, C. H. J., Jorge, P., … Kirillov, A. M. (2024). Sulfonyldibenzoate coordination polymers as bioactive dopants for polysaccharide films with antibacterial and antibiofilm properties. RSC Applied Interfaces. Royal Society of Chemistry (RSC). http://doi.org/10.1039/d3lf00123g2755-370110.1039/D3LF00123Ghttps://www.rsc.org/journals-books-databases/about-journals/rsc-applied-interfacesinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-10T01:20:25Zoai:repositorium.sdum.uminho.pt:1822/88509Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:37:11.807705Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Sulfonyldibenzoate coordination polymers as bioactive dopants for polysaccharide films with antibacterial and antibiofilm properties |
title |
Sulfonyldibenzoate coordination polymers as bioactive dopants for polysaccharide films with antibacterial and antibiofilm properties |
spellingShingle |
Sulfonyldibenzoate coordination polymers as bioactive dopants for polysaccharide films with antibacterial and antibiofilm properties Fernandes, Tiago A. |
title_short |
Sulfonyldibenzoate coordination polymers as bioactive dopants for polysaccharide films with antibacterial and antibiofilm properties |
title_full |
Sulfonyldibenzoate coordination polymers as bioactive dopants for polysaccharide films with antibacterial and antibiofilm properties |
title_fullStr |
Sulfonyldibenzoate coordination polymers as bioactive dopants for polysaccharide films with antibacterial and antibiofilm properties |
title_full_unstemmed |
Sulfonyldibenzoate coordination polymers as bioactive dopants for polysaccharide films with antibacterial and antibiofilm properties |
title_sort |
Sulfonyldibenzoate coordination polymers as bioactive dopants for polysaccharide films with antibacterial and antibiofilm properties |
author |
Fernandes, Tiago A. |
author_facet |
Fernandes, Tiago A. Macedo, Filipa Cabral, Rafaela G. Guiu, Telma Franco, Chris H. J. Jorge, Paula Sousa, Ana Catarina André, Vânia Cerca, Nuno Kirillov, Alexander M. |
author_role |
author |
author2 |
Macedo, Filipa Cabral, Rafaela G. Guiu, Telma Franco, Chris H. J. Jorge, Paula Sousa, Ana Catarina André, Vânia Cerca, Nuno Kirillov, Alexander M. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Fernandes, Tiago A. Macedo, Filipa Cabral, Rafaela G. Guiu, Telma Franco, Chris H. J. Jorge, Paula Sousa, Ana Catarina André, Vânia Cerca, Nuno Kirillov, Alexander M. |
description |
This work describes the preparation, characterization, and antimicrobial properties of bioactive silver(I) and copper(II) coordination polymers (bioCPs) and derived biopolymer materials. Two bioCPs, [Ag2(6-sdba)]n (1) and [Cu(4-sdba)H2O]n·1.5nH2O (2), were assembled from metal salt precursors and 4,4-sulfonyldibenzoic acid (H2sdba). Both compounds were used as dopants for preparing hybrid biopolymer films based on agarose (AGR) or potato starch (PS) as model polysaccharide biopolymers with varying rates of degradability and silver/copper release. BioCPs and derived biopolymer films (1@[AGR]n, 2@[AGR]n, 1@[PS]n, and 2@[PS]n) with a low loading of dopant (15 wt%) show promising antibacterial activity against Gram-positive (S. aureus and S. epidermidis) and Gram-negative (E. coli and P. aeruginosa) bacteria. Silver-doped biopolymer films also totally impair the formation of bacterial biofilms, with undetectable biofilm cells in several cases (7.5log or 99.99999% inhibition). By reporting new bioCPs and biopolymer films obtained from renewable polysaccharides, this multidisciplinary work extends the application of coordination compounds as components of hybrid functional materials with antimicrobial properties and prospective biomedical relevance. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024 2024-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/88509 |
url |
https://hdl.handle.net/1822/88509 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Fernandes, T. A., Macedo, F., Cabral, R. G., Guiu, T., Franco, C. H. J., Jorge, P., … Kirillov, A. M. (2024). Sulfonyldibenzoate coordination polymers as bioactive dopants for polysaccharide films with antibacterial and antibiofilm properties. RSC Applied Interfaces. Royal Society of Chemistry (RSC). http://doi.org/10.1039/d3lf00123g 2755-3701 10.1039/D3LF00123G https://www.rsc.org/journals-books-databases/about-journals/rsc-applied-interfaces |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Royal Society of Chemistry |
publisher.none.fl_str_mv |
Royal Society of Chemistry |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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