Alcohol consumption and gastric cancer risk - A pooled analysis within the StoP Project Consortium

Detalhes bibliográficos
Autor(a) principal: Rota, M
Data de Publicação: 2017
Outros Autores: Pelucchi, C, Bertuccio, P, Matsuo, K, Zhang, ZF, Ito, H, Hu, J, Johnson, KC, Palli, D, Ferraroni, M, Yu, GP, Muscat, J, Lunet, N, Peleteiro, B, Ye, W, Song, H, Zaridze, D, Maximovitch, D, Guevara, M, Fernández-Villa, T, Vioque, J, Navarrete-Muñoz, EM, Wolk, A, Orsini, N, Bellavia, A, Håkansson, N, Mu, L, Persiani, R, Kurtz, RC, Lagiou, A, Lagiou, P, Galeone, C, Bonzi, R, Boffetta, P, Boccia, S, Negri, E, la Vecchia, C
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10216/111527
Resumo: An association between heavy alcohol drinking and gastric cancer risk has been recently reported, but the issue is still open to discussion and quantification. We investigated the role of alcohol drinking on gastric cancer risk in the “Stomach cancer Pooling (StoP) Project,” a consortium of epidemiological studies. A total of 9,669 cases and 25,336 controls from 20 studies from Europe, Asia and North America were included. We estimated summary odds‐ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study‐specific ORs using random‐effects meta‐regression models. Compared with abstainers, drinkers of up to 4 drinks/day of alcohol had no increase in gastric cancer risk, while the ORs were 1.26 (95% CI, 1.08–1.48) for heavy (>4 to 6 drinks/day) and 1.48 (95% CI 1.29–1.70) for very heavy (>6 drinks/day) drinkers. The risk for drinkers of >4 drinks/day was higher in never smokers (OR 1.87, 95% CI 1.35–2.58) as compared with current smokers (OR 1.14, 95% CI 0.93–1.40). Somewhat stronger associations emerged with heavy drinking in cardia (OR 1.61, 95% CI 1.11–2.34) than in non‐cardia (OR 1.28, 95% CI 1.13–1.45) gastric cancers, and in intestinal‐type (OR 1.54, 95% CI 1.20–1.97) than in diffuse‐type (OR 1.29, 95% CI 1.05–1.58) cancers. The association was similar in strata of H. pylori infected (OR = 1.52, 95% CI 1.16–2.00) and noninfected subjects (OR = 1.69, 95% CI 0.95–3.01). Our collaborative pooled‐analysis provides definite, more precise quantitative evidence than previously available of an association between heavy alcohol drinking and gastric cancer risk.
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spelling Alcohol consumption and gastric cancer risk - A pooled analysis within the StoP Project ConsortiumAlcohol drinkingGastric cancerCase-control studiesPooled analysisRisk factorsAn association between heavy alcohol drinking and gastric cancer risk has been recently reported, but the issue is still open to discussion and quantification. We investigated the role of alcohol drinking on gastric cancer risk in the “Stomach cancer Pooling (StoP) Project,” a consortium of epidemiological studies. A total of 9,669 cases and 25,336 controls from 20 studies from Europe, Asia and North America were included. We estimated summary odds‐ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study‐specific ORs using random‐effects meta‐regression models. Compared with abstainers, drinkers of up to 4 drinks/day of alcohol had no increase in gastric cancer risk, while the ORs were 1.26 (95% CI, 1.08–1.48) for heavy (>4 to 6 drinks/day) and 1.48 (95% CI 1.29–1.70) for very heavy (>6 drinks/day) drinkers. The risk for drinkers of >4 drinks/day was higher in never smokers (OR 1.87, 95% CI 1.35–2.58) as compared with current smokers (OR 1.14, 95% CI 0.93–1.40). Somewhat stronger associations emerged with heavy drinking in cardia (OR 1.61, 95% CI 1.11–2.34) than in non‐cardia (OR 1.28, 95% CI 1.13–1.45) gastric cancers, and in intestinal‐type (OR 1.54, 95% CI 1.20–1.97) than in diffuse‐type (OR 1.29, 95% CI 1.05–1.58) cancers. The association was similar in strata of H. pylori infected (OR = 1.52, 95% CI 1.16–2.00) and noninfected subjects (OR = 1.69, 95% CI 0.95–3.01). Our collaborative pooled‐analysis provides definite, more precise quantitative evidence than previously available of an association between heavy alcohol drinking and gastric cancer risk.UICC20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10216/111527eng0020-713610.1002/ijc.30891Rota, MPelucchi, CBertuccio, PMatsuo, KZhang, ZFIto, HHu, JJohnson, KCPalli, DFerraroni, MYu, GPMuscat, JLunet, NPeleteiro, BYe, WSong, HZaridze, DMaximovitch, DGuevara, MFernández-Villa, TVioque, JNavarrete-Muñoz, EMWolk, AOrsini, NBellavia, AHåkansson, NMu, LPersiani, RKurtz, RCLagiou, ALagiou, PGaleone, CBonzi, RBoffetta, PBoccia, SNegri, Ela Vecchia, Cinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T12:47:24Zoai:repositorio-aberto.up.pt:10216/111527Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:26:45.723998Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Alcohol consumption and gastric cancer risk - A pooled analysis within the StoP Project Consortium
title Alcohol consumption and gastric cancer risk - A pooled analysis within the StoP Project Consortium
spellingShingle Alcohol consumption and gastric cancer risk - A pooled analysis within the StoP Project Consortium
Rota, M
Alcohol drinking
Gastric cancer
Case-control studies
Pooled analysis
Risk factors
title_short Alcohol consumption and gastric cancer risk - A pooled analysis within the StoP Project Consortium
title_full Alcohol consumption and gastric cancer risk - A pooled analysis within the StoP Project Consortium
title_fullStr Alcohol consumption and gastric cancer risk - A pooled analysis within the StoP Project Consortium
title_full_unstemmed Alcohol consumption and gastric cancer risk - A pooled analysis within the StoP Project Consortium
title_sort Alcohol consumption and gastric cancer risk - A pooled analysis within the StoP Project Consortium
author Rota, M
author_facet Rota, M
Pelucchi, C
Bertuccio, P
Matsuo, K
Zhang, ZF
Ito, H
Hu, J
Johnson, KC
Palli, D
Ferraroni, M
Yu, GP
Muscat, J
Lunet, N
Peleteiro, B
Ye, W
Song, H
Zaridze, D
Maximovitch, D
Guevara, M
Fernández-Villa, T
Vioque, J
Navarrete-Muñoz, EM
Wolk, A
Orsini, N
Bellavia, A
Håkansson, N
Mu, L
Persiani, R
Kurtz, RC
Lagiou, A
Lagiou, P
Galeone, C
Bonzi, R
Boffetta, P
Boccia, S
Negri, E
la Vecchia, C
author_role author
author2 Pelucchi, C
Bertuccio, P
Matsuo, K
Zhang, ZF
Ito, H
Hu, J
Johnson, KC
Palli, D
Ferraroni, M
Yu, GP
Muscat, J
Lunet, N
Peleteiro, B
Ye, W
Song, H
Zaridze, D
Maximovitch, D
Guevara, M
Fernández-Villa, T
Vioque, J
Navarrete-Muñoz, EM
Wolk, A
Orsini, N
Bellavia, A
Håkansson, N
Mu, L
Persiani, R
Kurtz, RC
Lagiou, A
Lagiou, P
Galeone, C
Bonzi, R
Boffetta, P
Boccia, S
Negri, E
la Vecchia, C
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rota, M
Pelucchi, C
Bertuccio, P
Matsuo, K
Zhang, ZF
Ito, H
Hu, J
Johnson, KC
Palli, D
Ferraroni, M
Yu, GP
Muscat, J
Lunet, N
Peleteiro, B
Ye, W
Song, H
Zaridze, D
Maximovitch, D
Guevara, M
Fernández-Villa, T
Vioque, J
Navarrete-Muñoz, EM
Wolk, A
Orsini, N
Bellavia, A
Håkansson, N
Mu, L
Persiani, R
Kurtz, RC
Lagiou, A
Lagiou, P
Galeone, C
Bonzi, R
Boffetta, P
Boccia, S
Negri, E
la Vecchia, C
dc.subject.por.fl_str_mv Alcohol drinking
Gastric cancer
Case-control studies
Pooled analysis
Risk factors
topic Alcohol drinking
Gastric cancer
Case-control studies
Pooled analysis
Risk factors
description An association between heavy alcohol drinking and gastric cancer risk has been recently reported, but the issue is still open to discussion and quantification. We investigated the role of alcohol drinking on gastric cancer risk in the “Stomach cancer Pooling (StoP) Project,” a consortium of epidemiological studies. A total of 9,669 cases and 25,336 controls from 20 studies from Europe, Asia and North America were included. We estimated summary odds‐ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study‐specific ORs using random‐effects meta‐regression models. Compared with abstainers, drinkers of up to 4 drinks/day of alcohol had no increase in gastric cancer risk, while the ORs were 1.26 (95% CI, 1.08–1.48) for heavy (>4 to 6 drinks/day) and 1.48 (95% CI 1.29–1.70) for very heavy (>6 drinks/day) drinkers. The risk for drinkers of >4 drinks/day was higher in never smokers (OR 1.87, 95% CI 1.35–2.58) as compared with current smokers (OR 1.14, 95% CI 0.93–1.40). Somewhat stronger associations emerged with heavy drinking in cardia (OR 1.61, 95% CI 1.11–2.34) than in non‐cardia (OR 1.28, 95% CI 1.13–1.45) gastric cancers, and in intestinal‐type (OR 1.54, 95% CI 1.20–1.97) than in diffuse‐type (OR 1.29, 95% CI 1.05–1.58) cancers. The association was similar in strata of H. pylori infected (OR = 1.52, 95% CI 1.16–2.00) and noninfected subjects (OR = 1.69, 95% CI 0.95–3.01). Our collaborative pooled‐analysis provides definite, more precise quantitative evidence than previously available of an association between heavy alcohol drinking and gastric cancer risk.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10216/111527
url http://hdl.handle.net/10216/111527
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0020-7136
10.1002/ijc.30891
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv UICC
publisher.none.fl_str_mv UICC
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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