Alcohol consumption and gastric cancer risk - A pooled analysis within the StoP Project Consortium
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10216/111527 |
Resumo: | An association between heavy alcohol drinking and gastric cancer risk has been recently reported, but the issue is still open to discussion and quantification. We investigated the role of alcohol drinking on gastric cancer risk in the “Stomach cancer Pooling (StoP) Project,” a consortium of epidemiological studies. A total of 9,669 cases and 25,336 controls from 20 studies from Europe, Asia and North America were included. We estimated summary odds‐ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study‐specific ORs using random‐effects meta‐regression models. Compared with abstainers, drinkers of up to 4 drinks/day of alcohol had no increase in gastric cancer risk, while the ORs were 1.26 (95% CI, 1.08–1.48) for heavy (>4 to 6 drinks/day) and 1.48 (95% CI 1.29–1.70) for very heavy (>6 drinks/day) drinkers. The risk for drinkers of >4 drinks/day was higher in never smokers (OR 1.87, 95% CI 1.35–2.58) as compared with current smokers (OR 1.14, 95% CI 0.93–1.40). Somewhat stronger associations emerged with heavy drinking in cardia (OR 1.61, 95% CI 1.11–2.34) than in non‐cardia (OR 1.28, 95% CI 1.13–1.45) gastric cancers, and in intestinal‐type (OR 1.54, 95% CI 1.20–1.97) than in diffuse‐type (OR 1.29, 95% CI 1.05–1.58) cancers. The association was similar in strata of H. pylori infected (OR = 1.52, 95% CI 1.16–2.00) and noninfected subjects (OR = 1.69, 95% CI 0.95–3.01). Our collaborative pooled‐analysis provides definite, more precise quantitative evidence than previously available of an association between heavy alcohol drinking and gastric cancer risk. |
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Alcohol consumption and gastric cancer risk - A pooled analysis within the StoP Project ConsortiumAlcohol drinkingGastric cancerCase-control studiesPooled analysisRisk factorsAn association between heavy alcohol drinking and gastric cancer risk has been recently reported, but the issue is still open to discussion and quantification. We investigated the role of alcohol drinking on gastric cancer risk in the “Stomach cancer Pooling (StoP) Project,” a consortium of epidemiological studies. A total of 9,669 cases and 25,336 controls from 20 studies from Europe, Asia and North America were included. We estimated summary odds‐ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study‐specific ORs using random‐effects meta‐regression models. Compared with abstainers, drinkers of up to 4 drinks/day of alcohol had no increase in gastric cancer risk, while the ORs were 1.26 (95% CI, 1.08–1.48) for heavy (>4 to 6 drinks/day) and 1.48 (95% CI 1.29–1.70) for very heavy (>6 drinks/day) drinkers. The risk for drinkers of >4 drinks/day was higher in never smokers (OR 1.87, 95% CI 1.35–2.58) as compared with current smokers (OR 1.14, 95% CI 0.93–1.40). Somewhat stronger associations emerged with heavy drinking in cardia (OR 1.61, 95% CI 1.11–2.34) than in non‐cardia (OR 1.28, 95% CI 1.13–1.45) gastric cancers, and in intestinal‐type (OR 1.54, 95% CI 1.20–1.97) than in diffuse‐type (OR 1.29, 95% CI 1.05–1.58) cancers. The association was similar in strata of H. pylori infected (OR = 1.52, 95% CI 1.16–2.00) and noninfected subjects (OR = 1.69, 95% CI 0.95–3.01). Our collaborative pooled‐analysis provides definite, more precise quantitative evidence than previously available of an association between heavy alcohol drinking and gastric cancer risk.UICC20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10216/111527eng0020-713610.1002/ijc.30891Rota, MPelucchi, CBertuccio, PMatsuo, KZhang, ZFIto, HHu, JJohnson, KCPalli, DFerraroni, MYu, GPMuscat, JLunet, NPeleteiro, BYe, WSong, HZaridze, DMaximovitch, DGuevara, MFernández-Villa, TVioque, JNavarrete-Muñoz, EMWolk, AOrsini, NBellavia, AHåkansson, NMu, LPersiani, RKurtz, RCLagiou, ALagiou, PGaleone, CBonzi, RBoffetta, PBoccia, SNegri, Ela Vecchia, Cinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T12:47:24Zoai:repositorio-aberto.up.pt:10216/111527Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:26:45.723998Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Alcohol consumption and gastric cancer risk - A pooled analysis within the StoP Project Consortium |
title |
Alcohol consumption and gastric cancer risk - A pooled analysis within the StoP Project Consortium |
spellingShingle |
Alcohol consumption and gastric cancer risk - A pooled analysis within the StoP Project Consortium Rota, M Alcohol drinking Gastric cancer Case-control studies Pooled analysis Risk factors |
title_short |
Alcohol consumption and gastric cancer risk - A pooled analysis within the StoP Project Consortium |
title_full |
Alcohol consumption and gastric cancer risk - A pooled analysis within the StoP Project Consortium |
title_fullStr |
Alcohol consumption and gastric cancer risk - A pooled analysis within the StoP Project Consortium |
title_full_unstemmed |
Alcohol consumption and gastric cancer risk - A pooled analysis within the StoP Project Consortium |
title_sort |
Alcohol consumption and gastric cancer risk - A pooled analysis within the StoP Project Consortium |
author |
Rota, M |
author_facet |
Rota, M Pelucchi, C Bertuccio, P Matsuo, K Zhang, ZF Ito, H Hu, J Johnson, KC Palli, D Ferraroni, M Yu, GP Muscat, J Lunet, N Peleteiro, B Ye, W Song, H Zaridze, D Maximovitch, D Guevara, M Fernández-Villa, T Vioque, J Navarrete-Muñoz, EM Wolk, A Orsini, N Bellavia, A Håkansson, N Mu, L Persiani, R Kurtz, RC Lagiou, A Lagiou, P Galeone, C Bonzi, R Boffetta, P Boccia, S Negri, E la Vecchia, C |
author_role |
author |
author2 |
Pelucchi, C Bertuccio, P Matsuo, K Zhang, ZF Ito, H Hu, J Johnson, KC Palli, D Ferraroni, M Yu, GP Muscat, J Lunet, N Peleteiro, B Ye, W Song, H Zaridze, D Maximovitch, D Guevara, M Fernández-Villa, T Vioque, J Navarrete-Muñoz, EM Wolk, A Orsini, N Bellavia, A Håkansson, N Mu, L Persiani, R Kurtz, RC Lagiou, A Lagiou, P Galeone, C Bonzi, R Boffetta, P Boccia, S Negri, E la Vecchia, C |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Rota, M Pelucchi, C Bertuccio, P Matsuo, K Zhang, ZF Ito, H Hu, J Johnson, KC Palli, D Ferraroni, M Yu, GP Muscat, J Lunet, N Peleteiro, B Ye, W Song, H Zaridze, D Maximovitch, D Guevara, M Fernández-Villa, T Vioque, J Navarrete-Muñoz, EM Wolk, A Orsini, N Bellavia, A Håkansson, N Mu, L Persiani, R Kurtz, RC Lagiou, A Lagiou, P Galeone, C Bonzi, R Boffetta, P Boccia, S Negri, E la Vecchia, C |
dc.subject.por.fl_str_mv |
Alcohol drinking Gastric cancer Case-control studies Pooled analysis Risk factors |
topic |
Alcohol drinking Gastric cancer Case-control studies Pooled analysis Risk factors |
description |
An association between heavy alcohol drinking and gastric cancer risk has been recently reported, but the issue is still open to discussion and quantification. We investigated the role of alcohol drinking on gastric cancer risk in the “Stomach cancer Pooling (StoP) Project,” a consortium of epidemiological studies. A total of 9,669 cases and 25,336 controls from 20 studies from Europe, Asia and North America were included. We estimated summary odds‐ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study‐specific ORs using random‐effects meta‐regression models. Compared with abstainers, drinkers of up to 4 drinks/day of alcohol had no increase in gastric cancer risk, while the ORs were 1.26 (95% CI, 1.08–1.48) for heavy (>4 to 6 drinks/day) and 1.48 (95% CI 1.29–1.70) for very heavy (>6 drinks/day) drinkers. The risk for drinkers of >4 drinks/day was higher in never smokers (OR 1.87, 95% CI 1.35–2.58) as compared with current smokers (OR 1.14, 95% CI 0.93–1.40). Somewhat stronger associations emerged with heavy drinking in cardia (OR 1.61, 95% CI 1.11–2.34) than in non‐cardia (OR 1.28, 95% CI 1.13–1.45) gastric cancers, and in intestinal‐type (OR 1.54, 95% CI 1.20–1.97) than in diffuse‐type (OR 1.29, 95% CI 1.05–1.58) cancers. The association was similar in strata of H. pylori infected (OR = 1.52, 95% CI 1.16–2.00) and noninfected subjects (OR = 1.69, 95% CI 0.95–3.01). Our collaborative pooled‐analysis provides definite, more precise quantitative evidence than previously available of an association between heavy alcohol drinking and gastric cancer risk. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10216/111527 |
url |
http://hdl.handle.net/10216/111527 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0020-7136 10.1002/ijc.30891 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
UICC |
publisher.none.fl_str_mv |
UICC |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799135573898690560 |