Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids

Detalhes bibliográficos
Autor(a) principal: Barreto, Maria do Carmo
Data de Publicação: 2003
Outros Autores: Pinto, Ruy Eugénio, Arrabaça, João Daniel, Pavão, Maria Leonor
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.3/2338
Resumo: Copyright © 2003 Elsevier Ireland Ltd. All rights reserved.
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spelling Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloidsProtoberberine AlkaloidsBenzophenanthridine AlkaloidsStructure–activity RelationshipMitochondrial RespirationNADH DehydrogenaseSuccinate DehydrogenaseCopyright © 2003 Elsevier Ireland Ltd. All rights reserved.The alkaloids from Chelidonium majus L. which had a significant inhibitory effect in mitochondrial respiration were those which contain a positive charge due to a quaternary nitrogen atom, i.e., chelerythrine, sanguinarine, berberine and coptisine, both with malate+glutamate or with succinate as substrates. When malate+glutamate was used as substrate, chelerythrine and berberine, which contain methoxy groups, were particularly more active, since they had a strong effect even at low concentrations. In submitochondrial particles, berberine and coptisine had a marked inhibitory effect on NADH dehydrogenase activity but practically no effect on succinate dehydrogenase activity, whereas chelerythrine and sanguinarine inhibited more strongly succinate dehydrogenase than NADH dehydrogenase, which is in agreement with the results found for mitochondrial respiration. Protopine and allocryptopine, which did not inhibit mitochondrial respiration, strongly inhibited NADH dehydrogenase in submitochondrial particles, but had no effect on succinate dehydrogenase activity.ElsevierRepositório da Universidade dos AçoresBarreto, Maria do CarmoPinto, Ruy EugénioArrabaça, João DanielPavão, Maria Leonor2013-10-24T12:50:33Z2003-122003-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.3/2338engBARRETO, M.C., PINTO, R.E., ARRABAÇA, J.D. & PAVÃO M.L. (2003). "Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids". «Toxicology Letters», 146(1), 37-47. [Article In Press].0378-4274 (Print)info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-12-20T14:30:08Zoai:repositorio.uac.pt:10400.3/2338Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:25:01.282648Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids
title Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids
spellingShingle Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids
Barreto, Maria do Carmo
Protoberberine Alkaloids
Benzophenanthridine Alkaloids
Structure–activity Relationship
Mitochondrial Respiration
NADH Dehydrogenase
Succinate Dehydrogenase
title_short Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids
title_full Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids
title_fullStr Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids
title_full_unstemmed Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids
title_sort Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids
author Barreto, Maria do Carmo
author_facet Barreto, Maria do Carmo
Pinto, Ruy Eugénio
Arrabaça, João Daniel
Pavão, Maria Leonor
author_role author
author2 Pinto, Ruy Eugénio
Arrabaça, João Daniel
Pavão, Maria Leonor
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade dos Açores
dc.contributor.author.fl_str_mv Barreto, Maria do Carmo
Pinto, Ruy Eugénio
Arrabaça, João Daniel
Pavão, Maria Leonor
dc.subject.por.fl_str_mv Protoberberine Alkaloids
Benzophenanthridine Alkaloids
Structure–activity Relationship
Mitochondrial Respiration
NADH Dehydrogenase
Succinate Dehydrogenase
topic Protoberberine Alkaloids
Benzophenanthridine Alkaloids
Structure–activity Relationship
Mitochondrial Respiration
NADH Dehydrogenase
Succinate Dehydrogenase
description Copyright © 2003 Elsevier Ireland Ltd. All rights reserved.
publishDate 2003
dc.date.none.fl_str_mv 2003-12
2003-12-01T00:00:00Z
2013-10-24T12:50:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.3/2338
url http://hdl.handle.net/10400.3/2338
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv BARRETO, M.C., PINTO, R.E., ARRABAÇA, J.D. & PAVÃO M.L. (2003). "Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids". «Toxicology Letters», 146(1), 37-47. [Article In Press].
0378-4274 (Print)
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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