Prognostic value of Monocarboxylate Transporter 1 overexpression in cancer: a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/86817 |
Resumo: | Energy production by cancer is driven by accelerated glycolysis, independently of oxygen levels, which results in increased lactate production. Lactate is shuttled to and from cancer cells via monocarboxylate transporters (MCTs). MCT1 works both as an importer and an extruder of lactate, being widely studied in recent years and generally associated with a cancer aggressiveness phenotype. The aim of this systematic review was to assess the prognostic value of MCT1 immunoexpression in different malignancies. Study collection was performed by searching nine different databases (PubMed, EMBASE, ScienceDirect, Scopus, Cochrane Library, Web of Science, OVID, TRIP and PsycINFO), using the keywords “cancer”, “Monocarboxylate transporter 1”, “SLC16A1” and “prognosis”. Results showed that MCT1 is an indicator of poor prognosis and decreased survival for cancer patients in sixteen types of malignancies; associations between the transporter’s overexpression and larger tumour sizes, higher disease stage/grade and metastasis occurrence were also frequently observed. Yet, MCT1 overexpression correlated with better outcomes in colorectal cancer, pancreatic ductal adenocarcinoma and non-small cell lung cancer patients. These results support the applicability of MCT1 as a biomarker of prognosis, although larger cohorts would be necessary to validate the overall role of MCT1 as an outcome predictor. |
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Prognostic value of Monocarboxylate Transporter 1 overexpression in cancer: a systematic reviewCancerWarburg effectMonocarboxylate transporter 1ImmunoexpressionPrognosisScience & TechnologyEnergy production by cancer is driven by accelerated glycolysis, independently of oxygen levels, which results in increased lactate production. Lactate is shuttled to and from cancer cells via monocarboxylate transporters (MCTs). MCT1 works both as an importer and an extruder of lactate, being widely studied in recent years and generally associated with a cancer aggressiveness phenotype. The aim of this systematic review was to assess the prognostic value of MCT1 immunoexpression in different malignancies. Study collection was performed by searching nine different databases (PubMed, EMBASE, ScienceDirect, Scopus, Cochrane Library, Web of Science, OVID, TRIP and PsycINFO), using the keywords “cancer”, “Monocarboxylate transporter 1”, “SLC16A1” and “prognosis”. Results showed that MCT1 is an indicator of poor prognosis and decreased survival for cancer patients in sixteen types of malignancies; associations between the transporter’s overexpression and larger tumour sizes, higher disease stage/grade and metastasis occurrence were also frequently observed. Yet, MCT1 overexpression correlated with better outcomes in colorectal cancer, pancreatic ductal adenocarcinoma and non-small cell lung cancer patients. These results support the applicability of MCT1 as a biomarker of prognosis, although larger cohorts would be necessary to validate the overall role of MCT1 as an outcome predictor.This work has been funded by National funds, through the Foundation for Science and Technology (FCT)-project UIDB/50026/2020 and UIDP/50026/2020 and by the project NORTE-01- 0145-FEDER-000055, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). A.S., M.C.C. and J.A. received fellowships from FCT, references 2022.11018.BD (A.S.), 2022.10233.BD (M.C.C.) and SFRH/BPD/116784/2016 (J.A.).Multidisciplinary Digital Publishing Institute (MDPI)Universidade do MinhoSilva, AnaCerqueira, Mónica CostaRosa, BeatrizSobral, CatarinaPinto-Ribeiro, FilipaCosta, Marta Sílvia FreitasBaltazar, FátimaAfonso, Julieta Alexandra Pereira2023-03-072023-03-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/86817engSilva, A.; Cerqueira, M.C.; Rosa, B.; Sobral, C.; Pinto-Ribeiro, F.; Costa, M.F.; Baltazar, F.; Afonso, J. Prognostic Value of Monocarboxylate Transporter 1 Overexpression in Cancer: A Systematic Review. Int. J. Mol. Sci. 2023, 24, 5141. https://doi.org/10.3390/ijms240651411661-65961422-006710.3390/ijms24065141369822175141https://www.mdpi.com/1422-0067/24/6/5141info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-14T01:20:40Zoai:repositorium.sdum.uminho.pt:1822/86817Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:35:26.289296Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Prognostic value of Monocarboxylate Transporter 1 overexpression in cancer: a systematic review |
title |
Prognostic value of Monocarboxylate Transporter 1 overexpression in cancer: a systematic review |
spellingShingle |
Prognostic value of Monocarboxylate Transporter 1 overexpression in cancer: a systematic review Silva, Ana Cancer Warburg effect Monocarboxylate transporter 1 Immunoexpression Prognosis Science & Technology |
title_short |
Prognostic value of Monocarboxylate Transporter 1 overexpression in cancer: a systematic review |
title_full |
Prognostic value of Monocarboxylate Transporter 1 overexpression in cancer: a systematic review |
title_fullStr |
Prognostic value of Monocarboxylate Transporter 1 overexpression in cancer: a systematic review |
title_full_unstemmed |
Prognostic value of Monocarboxylate Transporter 1 overexpression in cancer: a systematic review |
title_sort |
Prognostic value of Monocarboxylate Transporter 1 overexpression in cancer: a systematic review |
author |
Silva, Ana |
author_facet |
Silva, Ana Cerqueira, Mónica Costa Rosa, Beatriz Sobral, Catarina Pinto-Ribeiro, Filipa Costa, Marta Sílvia Freitas Baltazar, Fátima Afonso, Julieta Alexandra Pereira |
author_role |
author |
author2 |
Cerqueira, Mónica Costa Rosa, Beatriz Sobral, Catarina Pinto-Ribeiro, Filipa Costa, Marta Sílvia Freitas Baltazar, Fátima Afonso, Julieta Alexandra Pereira |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Silva, Ana Cerqueira, Mónica Costa Rosa, Beatriz Sobral, Catarina Pinto-Ribeiro, Filipa Costa, Marta Sílvia Freitas Baltazar, Fátima Afonso, Julieta Alexandra Pereira |
dc.subject.por.fl_str_mv |
Cancer Warburg effect Monocarboxylate transporter 1 Immunoexpression Prognosis Science & Technology |
topic |
Cancer Warburg effect Monocarboxylate transporter 1 Immunoexpression Prognosis Science & Technology |
description |
Energy production by cancer is driven by accelerated glycolysis, independently of oxygen levels, which results in increased lactate production. Lactate is shuttled to and from cancer cells via monocarboxylate transporters (MCTs). MCT1 works both as an importer and an extruder of lactate, being widely studied in recent years and generally associated with a cancer aggressiveness phenotype. The aim of this systematic review was to assess the prognostic value of MCT1 immunoexpression in different malignancies. Study collection was performed by searching nine different databases (PubMed, EMBASE, ScienceDirect, Scopus, Cochrane Library, Web of Science, OVID, TRIP and PsycINFO), using the keywords “cancer”, “Monocarboxylate transporter 1”, “SLC16A1” and “prognosis”. Results showed that MCT1 is an indicator of poor prognosis and decreased survival for cancer patients in sixteen types of malignancies; associations between the transporter’s overexpression and larger tumour sizes, higher disease stage/grade and metastasis occurrence were also frequently observed. Yet, MCT1 overexpression correlated with better outcomes in colorectal cancer, pancreatic ductal adenocarcinoma and non-small cell lung cancer patients. These results support the applicability of MCT1 as a biomarker of prognosis, although larger cohorts would be necessary to validate the overall role of MCT1 as an outcome predictor. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-03-07 2023-03-07T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/86817 |
url |
https://hdl.handle.net/1822/86817 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Silva, A.; Cerqueira, M.C.; Rosa, B.; Sobral, C.; Pinto-Ribeiro, F.; Costa, M.F.; Baltazar, F.; Afonso, J. Prognostic Value of Monocarboxylate Transporter 1 Overexpression in Cancer: A Systematic Review. Int. J. Mol. Sci. 2023, 24, 5141. https://doi.org/10.3390/ijms24065141 1661-6596 1422-0067 10.3390/ijms24065141 36982217 5141 https://www.mdpi.com/1422-0067/24/6/5141 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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