Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammation
Autor(a) principal: | |
---|---|
Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/161759 |
Resumo: | CCVC8485 from Junta de Castilla y Leon, Spain. F.O.M., J.F.S. and M.G.A. are supported with CEEC contracts from the Portuguese Foundation for Science and Technology (CEECIND/04266/2017, CEEC IND/02428/2018 and 2021.03439.CEECIND, respectively). This work was also supported by Fundação para a Ciência e a Tecnologia”—FCT IBIMED (UIDP/04501/2020 and UIDB/04501/2020), UMIB (UIDB/00215/2020, and UIDP/00215/2020), ITR—Laboratory for Integrative and Translational Research in Population Health (LA/P/0064/2020), for the PhD student Patrícia C. Braga (UI/BD/150750/2020). Publisher Copyright: © 2023 by the authors. |
id |
RCAP_7e6f71b8828a4a6eeaf6ae5a788224f5 |
---|---|
oai_identifier_str |
oai:run.unl.pt:10362/161759 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammationchronic intermittent hypoxiainflammationinsulin resistancemetabolic disordersmitochondrial dysfunctionobstructive sleep apneaoxidative stressFood SciencePhysiologyBiochemistryMolecular BiologyClinical BiochemistryCell BiologyCCVC8485 from Junta de Castilla y Leon, Spain. F.O.M., J.F.S. and M.G.A. are supported with CEEC contracts from the Portuguese Foundation for Science and Technology (CEECIND/04266/2017, CEEC IND/02428/2018 and 2021.03439.CEECIND, respectively). This work was also supported by Fundação para a Ciência e a Tecnologia”—FCT IBIMED (UIDP/04501/2020 and UIDB/04501/2020), UMIB (UIDB/00215/2020, and UIDP/00215/2020), ITR—Laboratory for Integrative and Translational Research in Population Health (LA/P/0064/2020), for the PhD student Patrícia C. Braga (UI/BD/150750/2020). Publisher Copyright: © 2023 by the authors.The association between obstructive sleep apnea (OSA) and metabolic disorders is well-established; however, the underlying mechanisms that elucidate this relationship remain incompletely understood. Since the liver is a major organ in the maintenance of metabolic homeostasis, we hypothesize that liver dysfunction plays a crucial role in the pathogenesis of metabolic dysfunction associated with obstructive sleep apnea (OSA). Herein, we explored the underlying mechanisms of this association within the liver. Experiments were performed in male Wistar rats fed with a control or high fat (HF) diet (60% lipid-rich) for 12 weeks. Half of the groups were exposed to chronic intermittent hypoxia (CIH) (30 hypoxic (5% O2) cycles, 8 h/day) that mimics OSA, in the last 15 days. Insulin sensitivity and glucose tolerance were assessed. Liver samples were collected for evaluation of lipid deposition, insulin signaling, glucose homeostasis, hypoxia, oxidative stress, antioxidant defenses, mitochondrial biogenesis and inflammation. Both the CIH and HF diet induced dysmetabolism, a state not aggravated in animals submitted to HF plus CIH. CIH aggravates hepatic lipid deposition in obese animals. Hypoxia-inducible factors levels were altered by these stimuli. CIH decreased the levels of oxidative phosphorylation complexes in both groups and the levels of SOD-1. The HF diet reduced mitochondrial density and hepatic antioxidant capacity. The CIH and HF diet produced alterations in cysteine-related thiols and pro-inflammatory markers. The results obtained suggest that hepatic mitochondrial dysfunction and oxidative stress, leading to inflammation, may be significant factors contributing to the development of dysmetabolism associated with OSA.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)iNOVA4Health - pólo NMSRUNFernandes, Joana L.Martins, Fátima O.Olea, ElenaPrieto-Lloret, JesusBraga, Patrícia C.Sacramento, Joana F.Sequeira, Catarina O.Negrinho, Ana P.Pereira, Sofia A.Alves, Marco G.Rocher, AsunciónConde, Silvia V.2023-12-29T22:32:32Z2023-112023-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/161759eng2076-3921PURE: 78177086https://doi.org/10.3390/antiox12111910info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:44:38Zoai:run.unl.pt:10362/161759Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:58:38.677101Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammation |
title |
Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammation |
spellingShingle |
Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammation Fernandes, Joana L. chronic intermittent hypoxia inflammation insulin resistance metabolic disorders mitochondrial dysfunction obstructive sleep apnea oxidative stress Food Science Physiology Biochemistry Molecular Biology Clinical Biochemistry Cell Biology |
title_short |
Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammation |
title_full |
Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammation |
title_fullStr |
Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammation |
title_full_unstemmed |
Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammation |
title_sort |
Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammation |
author |
Fernandes, Joana L. |
author_facet |
Fernandes, Joana L. Martins, Fátima O. Olea, Elena Prieto-Lloret, Jesus Braga, Patrícia C. Sacramento, Joana F. Sequeira, Catarina O. Negrinho, Ana P. Pereira, Sofia A. Alves, Marco G. Rocher, Asunción Conde, Silvia V. |
author_role |
author |
author2 |
Martins, Fátima O. Olea, Elena Prieto-Lloret, Jesus Braga, Patrícia C. Sacramento, Joana F. Sequeira, Catarina O. Negrinho, Ana P. Pereira, Sofia A. Alves, Marco G. Rocher, Asunción Conde, Silvia V. |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) iNOVA4Health - pólo NMS RUN |
dc.contributor.author.fl_str_mv |
Fernandes, Joana L. Martins, Fátima O. Olea, Elena Prieto-Lloret, Jesus Braga, Patrícia C. Sacramento, Joana F. Sequeira, Catarina O. Negrinho, Ana P. Pereira, Sofia A. Alves, Marco G. Rocher, Asunción Conde, Silvia V. |
dc.subject.por.fl_str_mv |
chronic intermittent hypoxia inflammation insulin resistance metabolic disorders mitochondrial dysfunction obstructive sleep apnea oxidative stress Food Science Physiology Biochemistry Molecular Biology Clinical Biochemistry Cell Biology |
topic |
chronic intermittent hypoxia inflammation insulin resistance metabolic disorders mitochondrial dysfunction obstructive sleep apnea oxidative stress Food Science Physiology Biochemistry Molecular Biology Clinical Biochemistry Cell Biology |
description |
CCVC8485 from Junta de Castilla y Leon, Spain. F.O.M., J.F.S. and M.G.A. are supported with CEEC contracts from the Portuguese Foundation for Science and Technology (CEECIND/04266/2017, CEEC IND/02428/2018 and 2021.03439.CEECIND, respectively). This work was also supported by Fundação para a Ciência e a Tecnologia”—FCT IBIMED (UIDP/04501/2020 and UIDB/04501/2020), UMIB (UIDB/00215/2020, and UIDP/00215/2020), ITR—Laboratory for Integrative and Translational Research in Population Health (LA/P/0064/2020), for the PhD student Patrícia C. Braga (UI/BD/150750/2020). Publisher Copyright: © 2023 by the authors. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-12-29T22:32:32Z 2023-11 2023-11-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/161759 |
url |
http://hdl.handle.net/10362/161759 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2076-3921 PURE: 78177086 https://doi.org/10.3390/antiox12111910 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799138167375265792 |