Deep brain stimulation of the anterior nucleus of the thalamus in drug-resistant epilepsy in the MORE multicenter patient registry
| Autor(a) principal: | |
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| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/57325 |
Resumo: | Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Deep brain stimulation of the anterior nucleus of the thalamus in drug-resistant epilepsy in the MORE multicenter patient registryCopyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Background and objectives: The efficacy of deep brain stimulation of the anterior nucleus of the thalamus (ANT DBS) in patients with drug-resistant epilepsy (DRE) was demonstrated in the double-blind Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy randomized controlled trial. The Medtronic Registry for Epilepsy (MORE) aims to understand the safety and longer-term effectiveness of ANT DBS therapy in routine clinical practice. Methods: MORE is an observational registry collecting prospective and retrospective clinical data. Participants were at least 18 years old, with focal DRE recruited across 25 centers from 13 countries. They were followed for at least 2 years in terms of seizure frequency (SF), responder rate (RR), health-related quality of life (Quality of Life in Epilepsy Inventory 31), depression, and safety outcomes. Results: Of the 191 patients recruited, 170 (mean [SD] age of 35.6 [10.7] years, 43% female) were implanted with DBS therapy and met all eligibility criteria. At baseline, 38% of patients reported cognitive impairment. The median monthly SF decreased by 33.1% from 15.8 at baseline to 8.8 at 2 years (p < 0.0001) with 32.3% RR. In the subgroup of 47 patients who completed 5 years of follow-up, the median monthly SF decreased by 55.1% from 16 at baseline to 7.9 at 5 years (p < 0.0001) with 53.2% RR. High-volume centers (>10 implantations) had 42.8% reduction in median monthly SF by 2 years in comparison with 25.8% in low-volume center. In patients with cognitive impairment, the reduction in median monthly SF was 26.0% by 2 years compared with 36.1% in patients without cognitive impairment. The most frequently reported adverse events were changes (e.g., increased frequency/severity) in seizure (16%), memory impairment (patient-reported complaint, 15%), depressive mood (patient-reported complaint, 13%), and epilepsy (12%). One definite sudden unexpected death in epilepsy case was reported. Discussion: The MORE registry supports the effectiveness and safety of ANT DBS therapy in a real-world setting in the 2 years following implantation. Classification of evidence: This study provides Class IV evidence that ANT DBS reduces the frequency of seizures in patients with drug-resistant focal epilepsy.The MORE registry was sponsored and funded by Medtronic, plc.American Academy of NeurologyRepositório da Universidade de LisboaPeltola, JukkaColon, Albert J.Pimentel, JoséCoenen, Volker A.Gil-Nagel, AntonioGonçalves Ferreira, AntónioLehtimäki, KaiRyvlin, PhilippeTaylor, Rod S.Ackermans, LindaArdesch, JacquelineBentes, CarlaBosak, MagdalenaBurneo, Jorge G.Chamadoira, ClaraElger, Christian E.Erőss, LorándFabo, DánielFaulkner, HowardGawlowicz, JacekGharabaghi, AlirezaIacoangeli, MaurizioJanszky, JozsefJärvenpää, SoilaKaufmann, ElisabethKho, Kuan H.Kumlien, EvaLaufs, HelmutLettieri, ChristianLinhares, PauloNoachtar, SoheylParrent, AndrewPataraia, EkaterinaPatel, Nikunj K.Peralta, AnaRácz, AttilaRainha Campos, AlexandreRego, RicardoRicciuti, Riccardo A.Rona, SabineRouhl, Rob P.W.Schulze-Bonhage, AndreasSchuurman, RickSprengers, MathieuSufianov, AlbertTemel, YasinTheys, TomVan Paesschen, WimVan Roost, DirkVaz, RuiVonck, KristlWagner, LouisZwemmer, JackAbouihia, AbdallahBrionne, Thomas C.Gielen, FransBoon, Paul A.J.M.2023-05-03T11:42:09Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/57325engNeurology. 2023 May 2;100(18):e1852-e18650028-387810.1212/WNL.00000000002068871526-632Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:05:27Zoai:repositorio.ul.pt:10451/57325Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:07:44.077335Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Deep brain stimulation of the anterior nucleus of the thalamus in drug-resistant epilepsy in the MORE multicenter patient registry |
| title |
Deep brain stimulation of the anterior nucleus of the thalamus in drug-resistant epilepsy in the MORE multicenter patient registry |
| spellingShingle |
Deep brain stimulation of the anterior nucleus of the thalamus in drug-resistant epilepsy in the MORE multicenter patient registry Peltola, Jukka |
| title_short |
Deep brain stimulation of the anterior nucleus of the thalamus in drug-resistant epilepsy in the MORE multicenter patient registry |
| title_full |
Deep brain stimulation of the anterior nucleus of the thalamus in drug-resistant epilepsy in the MORE multicenter patient registry |
| title_fullStr |
Deep brain stimulation of the anterior nucleus of the thalamus in drug-resistant epilepsy in the MORE multicenter patient registry |
| title_full_unstemmed |
Deep brain stimulation of the anterior nucleus of the thalamus in drug-resistant epilepsy in the MORE multicenter patient registry |
| title_sort |
Deep brain stimulation of the anterior nucleus of the thalamus in drug-resistant epilepsy in the MORE multicenter patient registry |
| author |
Peltola, Jukka |
| author_facet |
Peltola, Jukka Colon, Albert J. Pimentel, José Coenen, Volker A. Gil-Nagel, Antonio Gonçalves Ferreira, António Lehtimäki, Kai Ryvlin, Philippe Taylor, Rod S. Ackermans, Linda Ardesch, Jacqueline Bentes, Carla Bosak, Magdalena Burneo, Jorge G. Chamadoira, Clara Elger, Christian E. Erőss, Loránd Fabo, Dániel Faulkner, Howard Gawlowicz, Jacek Gharabaghi, Alireza Iacoangeli, Maurizio Janszky, Jozsef Järvenpää, Soila Kaufmann, Elisabeth Kho, Kuan H. Kumlien, Eva Laufs, Helmut Lettieri, Christian Linhares, Paulo Noachtar, Soheyl Parrent, Andrew Pataraia, Ekaterina Patel, Nikunj K. Peralta, Ana Rácz, Attila Rainha Campos, Alexandre Rego, Ricardo Ricciuti, Riccardo A. Rona, Sabine Rouhl, Rob P.W. Schulze-Bonhage, Andreas Schuurman, Rick Sprengers, Mathieu Sufianov, Albert Temel, Yasin Theys, Tom Van Paesschen, Wim Van Roost, Dirk Vaz, Rui Vonck, Kristl Wagner, Louis Zwemmer, Jack Abouihia, Abdallah Brionne, Thomas C. Gielen, Frans Boon, Paul A.J.M. |
| author_role |
author |
| author2 |
Colon, Albert J. Pimentel, José Coenen, Volker A. Gil-Nagel, Antonio Gonçalves Ferreira, António Lehtimäki, Kai Ryvlin, Philippe Taylor, Rod S. Ackermans, Linda Ardesch, Jacqueline Bentes, Carla Bosak, Magdalena Burneo, Jorge G. Chamadoira, Clara Elger, Christian E. Erőss, Loránd Fabo, Dániel Faulkner, Howard Gawlowicz, Jacek Gharabaghi, Alireza Iacoangeli, Maurizio Janszky, Jozsef Järvenpää, Soila Kaufmann, Elisabeth Kho, Kuan H. Kumlien, Eva Laufs, Helmut Lettieri, Christian Linhares, Paulo Noachtar, Soheyl Parrent, Andrew Pataraia, Ekaterina Patel, Nikunj K. Peralta, Ana Rácz, Attila Rainha Campos, Alexandre Rego, Ricardo Ricciuti, Riccardo A. Rona, Sabine Rouhl, Rob P.W. Schulze-Bonhage, Andreas Schuurman, Rick Sprengers, Mathieu Sufianov, Albert Temel, Yasin Theys, Tom Van Paesschen, Wim Van Roost, Dirk Vaz, Rui Vonck, Kristl Wagner, Louis Zwemmer, Jack Abouihia, Abdallah Brionne, Thomas C. Gielen, Frans Boon, Paul A.J.M. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Peltola, Jukka Colon, Albert J. Pimentel, José Coenen, Volker A. Gil-Nagel, Antonio Gonçalves Ferreira, António Lehtimäki, Kai Ryvlin, Philippe Taylor, Rod S. Ackermans, Linda Ardesch, Jacqueline Bentes, Carla Bosak, Magdalena Burneo, Jorge G. Chamadoira, Clara Elger, Christian E. Erőss, Loránd Fabo, Dániel Faulkner, Howard Gawlowicz, Jacek Gharabaghi, Alireza Iacoangeli, Maurizio Janszky, Jozsef Järvenpää, Soila Kaufmann, Elisabeth Kho, Kuan H. Kumlien, Eva Laufs, Helmut Lettieri, Christian Linhares, Paulo Noachtar, Soheyl Parrent, Andrew Pataraia, Ekaterina Patel, Nikunj K. Peralta, Ana Rácz, Attila Rainha Campos, Alexandre Rego, Ricardo Ricciuti, Riccardo A. Rona, Sabine Rouhl, Rob P.W. Schulze-Bonhage, Andreas Schuurman, Rick Sprengers, Mathieu Sufianov, Albert Temel, Yasin Theys, Tom Van Paesschen, Wim Van Roost, Dirk Vaz, Rui Vonck, Kristl Wagner, Louis Zwemmer, Jack Abouihia, Abdallah Brionne, Thomas C. Gielen, Frans Boon, Paul A.J.M. |
| description |
Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| publishDate |
2023 |
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2023-05-03T11:42:09Z 2023 2023-01-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/57325 |
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http://hdl.handle.net/10451/57325 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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Neurology. 2023 May 2;100(18):e1852-e1865 0028-3878 10.1212/WNL.0000000000206887 1526-632X |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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American Academy of Neurology |
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American Academy of Neurology |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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