Osteoblasts and bone formation

Detalhes bibliográficos
Autor(a) principal: Caetano-Lopes, Joana
Data de Publicação: 2007
Outros Autores: Canhao, Helena, Fonseca, João Eurico
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/46797
Resumo: © 2007 Sociedade Portuguesa de Reumatologia
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spelling Osteoblasts and bone formationOsteoblastsBone FormationWnt/β-catenin signallingLeptinCbfa1© 2007 Sociedade Portuguesa de ReumatologiaBone is constantly being remodelled in a dynamic process where osteoblasts are responsible for bone formation and osteoclasts for its resorption. Osteoblasts are specialized mesenchymal cells that undergo a process of maturation where genes like core-binding factor α1 (Cbfa1) and osterix (Osx) play a very important role. Moreover, it was found recently that the Wnt/β-catenin pathway plays a part on osteoblast differentiation and proliferation. In fact, mutations on some of the proteins involved in this pathway, like the low-density lipoprotein receptor related protein 5/6 (LRP5/6), lead to bone diseases. Osteoblasts have also a role in the regulation of bone resorption through receptor activator of nuclear factor-κB (RANK) ligand (RANKL), that links to its receptor, RANK, on the surface of pre-osteoclast cells, inducing their differentiation and fusion. On the other hand, osteoblasts secrete a soluble decoy receptor (osteoprotegerin, OPG) that blocks RANK/RANKL interaction by binding to RANKL and, thus, prevents osteoclast differentiation and activation. Therefore, the balance between RANKL and OPG determines the formation and activity of osteoclasts. Another factor that influences bone mass is leptin, a hormone produced by adipocytes that have a dual effect. It can act through the central nervous system and diminish osteoblasts activity, or can have an osteogenic effect by binding directly to its receptors on the surface of osteoblast cells.Sociedade Portuguesa de ReumatologiaRepositório da Universidade de LisboaCaetano-Lopes, JoanaCanhao, HelenaFonseca, João Eurico2021-03-11T16:24:12Z20072007-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46797engActa Reumatol Port. 2007 Apr-Jun;32(2):103-1100303-464Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:49:16Zoai:repositorio.ul.pt:10451/46797Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:58:52.711115Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Osteoblasts and bone formation
title Osteoblasts and bone formation
spellingShingle Osteoblasts and bone formation
Caetano-Lopes, Joana
Osteoblasts
Bone Formation
Wnt/β-catenin signalling
Leptin
Cbfa1
title_short Osteoblasts and bone formation
title_full Osteoblasts and bone formation
title_fullStr Osteoblasts and bone formation
title_full_unstemmed Osteoblasts and bone formation
title_sort Osteoblasts and bone formation
author Caetano-Lopes, Joana
author_facet Caetano-Lopes, Joana
Canhao, Helena
Fonseca, João Eurico
author_role author
author2 Canhao, Helena
Fonseca, João Eurico
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Caetano-Lopes, Joana
Canhao, Helena
Fonseca, João Eurico
dc.subject.por.fl_str_mv Osteoblasts
Bone Formation
Wnt/β-catenin signalling
Leptin
Cbfa1
topic Osteoblasts
Bone Formation
Wnt/β-catenin signalling
Leptin
Cbfa1
description © 2007 Sociedade Portuguesa de Reumatologia
publishDate 2007
dc.date.none.fl_str_mv 2007
2007-01-01T00:00:00Z
2021-03-11T16:24:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/46797
url http://hdl.handle.net/10451/46797
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Reumatol Port. 2007 Apr-Jun;32(2):103-110
0303-464X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Reumatologia
publisher.none.fl_str_mv Sociedade Portuguesa de Reumatologia
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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