Determination of clonixin in plasma and urine by reversed-phase high-performance liquid chromatography

Detalhes bibliográficos
Autor(a) principal: Bica, A
Data de Publicação: 2000
Outros Autores: Farinha, A, Blume, H, Barbosa, CM
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://repositorio-aberto.up.pt/handle/10216/81245
Resumo: A reversed-phase high-performance liquid chromatographic method that enables the determination of clonixin in human plasma and urine samples is described. Recovery of the drug was over 87.6 and 80.7% for plasma and urine, respectively. The limit of quantitation of the method was established as 10 ng/ml in plasma and 20 ng/ml in urine samples, with RSDs of less than 11.1%. The applicability of the method was further assessed by determining the plasma concentrations time course of clonixin in six healthy volunteers after single oral dose administration of 150 and 300 mg of clonixin and Clonix,
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spelling Determination of clonixin in plasma and urine by reversed-phase high-performance liquid chromatographyQuímicaChemical sciencesA reversed-phase high-performance liquid chromatographic method that enables the determination of clonixin in human plasma and urine samples is described. Recovery of the drug was over 87.6 and 80.7% for plasma and urine, respectively. The limit of quantitation of the method was established as 10 ng/ml in plasma and 20 ng/ml in urine samples, with RSDs of less than 11.1%. The applicability of the method was further assessed by determining the plasma concentrations time course of clonixin in six healthy volunteers after single oral dose administration of 150 and 300 mg of clonixin and Clonix,20002000-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://repositorio-aberto.up.pt/handle/10216/81245eng0021-967310.1016/s0021-9673(00)00348-4Bica, AFarinha, ABlume, HBarbosa, CMinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T15:31:15Zoai:repositorio-aberto.up.pt:10216/81245Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:25:32.942843Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Determination of clonixin in plasma and urine by reversed-phase high-performance liquid chromatography
title Determination of clonixin in plasma and urine by reversed-phase high-performance liquid chromatography
spellingShingle Determination of clonixin in plasma and urine by reversed-phase high-performance liquid chromatography
Bica, A
Química
Chemical sciences
title_short Determination of clonixin in plasma and urine by reversed-phase high-performance liquid chromatography
title_full Determination of clonixin in plasma and urine by reversed-phase high-performance liquid chromatography
title_fullStr Determination of clonixin in plasma and urine by reversed-phase high-performance liquid chromatography
title_full_unstemmed Determination of clonixin in plasma and urine by reversed-phase high-performance liquid chromatography
title_sort Determination of clonixin in plasma and urine by reversed-phase high-performance liquid chromatography
author Bica, A
author_facet Bica, A
Farinha, A
Blume, H
Barbosa, CM
author_role author
author2 Farinha, A
Blume, H
Barbosa, CM
author2_role author
author
author
dc.contributor.author.fl_str_mv Bica, A
Farinha, A
Blume, H
Barbosa, CM
dc.subject.por.fl_str_mv Química
Chemical sciences
topic Química
Chemical sciences
description A reversed-phase high-performance liquid chromatographic method that enables the determination of clonixin in human plasma and urine samples is described. Recovery of the drug was over 87.6 and 80.7% for plasma and urine, respectively. The limit of quantitation of the method was established as 10 ng/ml in plasma and 20 ng/ml in urine samples, with RSDs of less than 11.1%. The applicability of the method was further assessed by determining the plasma concentrations time course of clonixin in six healthy volunteers after single oral dose administration of 150 and 300 mg of clonixin and Clonix,
publishDate 2000
dc.date.none.fl_str_mv 2000
2000-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio-aberto.up.pt/handle/10216/81245
url https://repositorio-aberto.up.pt/handle/10216/81245
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0021-9673
10.1016/s0021-9673(00)00348-4
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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