CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region
| Autor(a) principal: | |
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| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/133120 |
Resumo: | Funding Information: We acknowledge the participants in the study, without whom this research could not have been done. For laboratorial support the authors wish to show their appreciation to Gabriel Barbosa de Abreu (in memorian). To Norman Ratcliffe for the English revision of this manuscript. Part of this work is described in a Master?s Dissertation by PS, conducted at the Applied Microbiology and Parasitology Post-graduation Program, Federal Fluminense University. Publisher Copyright: © Copyright © 2021 Salles, Perce-da-Silva, Rossi, Raposo, Ramirez Ramirez, Pereira Bastos, Pratt-Riccio, Cassiano, Baptista, Cardoso, Banic and Machado. |
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CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon RegionCYP2D6Genetic polymorphismpharmacogeneticsPlasmodium vivaxprimaquinerelapsesPharmacologyPharmacology (medical)SDG 3 - Good Health and Well-beingParasitologia MédicaFunding Information: We acknowledge the participants in the study, without whom this research could not have been done. For laboratorial support the authors wish to show their appreciation to Gabriel Barbosa de Abreu (in memorian). To Norman Ratcliffe for the English revision of this manuscript. Part of this work is described in a Master?s Dissertation by PS, conducted at the Applied Microbiology and Parasitology Post-graduation Program, Federal Fluminense University. Publisher Copyright: © Copyright © 2021 Salles, Perce-da-Silva, Rossi, Raposo, Ramirez Ramirez, Pereira Bastos, Pratt-Riccio, Cassiano, Baptista, Cardoso, Banic and Machado.Genetic variability was linked with individual responses to treatment and susceptibility to malaria by Plasmodium vivax. Polymorphisms in the CYP2D6 gene may modulate enzyme level and activity, thereby affecting individual responses to pharmacological treatment. The aim of the study was to investigate whether or not CYP2D6 single nucleotide polymorphisms rs1065852, rs38920-97, rs16947 and rs28371725 are unequally distributed in malaria by Plasmodium vivax individuals from the Brazilian Amazon region. The blood samples were collected from 220 unrelated Plasmodium vivax patients from five different endemic areas. Genotyping was performed using SNaPshot® and real-time polymerase chain reaction methods. In all five areas, the rs1065852 (CYP2D6*10, C.100C > T), rs3892097 (CYP2D6*4, 1846C > T) and rs16947 (CYP2D6*2, C.2850G > A), as a homozygous genotype, showed the lowest frequencies. The rs28371725 (CYP2D6*41, 2988G > A) homozygous genotype was not detected, while the allele A was found in a single patient from Macapá region. No deviations from Hardy-Weinberg equilibrium were found, although a borderline p-value was observed (p = 0.048) for the SNP rs3892097 in Goianésia do Pará, Pará state. No significant associations were detected in these frequencies among the five studied areas. For the SNP rs3892097, a higher frequency was observed for the C/T heterozygous genotype in the Plácido de Castro and Macapá, Acre and Amapá states, respectively. The distribution of the CYP2D6 alleles investigated in the different areas of the Brazilian Amazon is not homogeneous. Further investigations are necessary in order to determine which alleles might be informative to assure optimal drug dosing recommendations based on experimental pharmacogenetics.Vector borne diseases and pathogens (VBD)Global Health and Tropical Medicine (GHTM)Instituto de Higiene e Medicina Tropical (IHMT)RUNSalles, Paula FerreiraPerce-da-Silva, Daiana SouzaRossi, Atila DuqueRaposo, Luisa RiehlRamirez Ramirez, Aina DanaisaPereira Bastos, Otílio MachadoPratt-Riccio, Lilian RoseCassiano, Gustavo CapattiBaptista, Andrea Regina SouzaCardoso, Cynthia ChesterBanic, Dalma MariaMachado, Ricardo Luiz Dantas2022-02-17T23:18:43Z2021-07-232021-07-23T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/133120eng1663-9812PURE: 33793059https://doi.org/10.3389/fphar.2021.542342info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:11:47Zoai:run.unl.pt:10362/133120Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:47:42.235310Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region |
| title |
CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region |
| spellingShingle |
CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region Salles, Paula Ferreira CYP2D6 Genetic polymorphism pharmacogenetics Plasmodium vivax primaquine relapses Pharmacology Pharmacology (medical) SDG 3 - Good Health and Well-being Parasitologia Médica |
| title_short |
CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region |
| title_full |
CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region |
| title_fullStr |
CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region |
| title_full_unstemmed |
CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region |
| title_sort |
CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region |
| author |
Salles, Paula Ferreira |
| author_facet |
Salles, Paula Ferreira Perce-da-Silva, Daiana Souza Rossi, Atila Duque Raposo, Luisa Riehl Ramirez Ramirez, Aina Danaisa Pereira Bastos, Otílio Machado Pratt-Riccio, Lilian Rose Cassiano, Gustavo Capatti Baptista, Andrea Regina Souza Cardoso, Cynthia Chester Banic, Dalma Maria Machado, Ricardo Luiz Dantas |
| author_role |
author |
| author2 |
Perce-da-Silva, Daiana Souza Rossi, Atila Duque Raposo, Luisa Riehl Ramirez Ramirez, Aina Danaisa Pereira Bastos, Otílio Machado Pratt-Riccio, Lilian Rose Cassiano, Gustavo Capatti Baptista, Andrea Regina Souza Cardoso, Cynthia Chester Banic, Dalma Maria Machado, Ricardo Luiz Dantas |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Vector borne diseases and pathogens (VBD) Global Health and Tropical Medicine (GHTM) Instituto de Higiene e Medicina Tropical (IHMT) RUN |
| dc.contributor.author.fl_str_mv |
Salles, Paula Ferreira Perce-da-Silva, Daiana Souza Rossi, Atila Duque Raposo, Luisa Riehl Ramirez Ramirez, Aina Danaisa Pereira Bastos, Otílio Machado Pratt-Riccio, Lilian Rose Cassiano, Gustavo Capatti Baptista, Andrea Regina Souza Cardoso, Cynthia Chester Banic, Dalma Maria Machado, Ricardo Luiz Dantas |
| dc.subject.por.fl_str_mv |
CYP2D6 Genetic polymorphism pharmacogenetics Plasmodium vivax primaquine relapses Pharmacology Pharmacology (medical) SDG 3 - Good Health and Well-being Parasitologia Médica |
| topic |
CYP2D6 Genetic polymorphism pharmacogenetics Plasmodium vivax primaquine relapses Pharmacology Pharmacology (medical) SDG 3 - Good Health and Well-being Parasitologia Médica |
| description |
Funding Information: We acknowledge the participants in the study, without whom this research could not have been done. For laboratorial support the authors wish to show their appreciation to Gabriel Barbosa de Abreu (in memorian). To Norman Ratcliffe for the English revision of this manuscript. Part of this work is described in a Master?s Dissertation by PS, conducted at the Applied Microbiology and Parasitology Post-graduation Program, Federal Fluminense University. Publisher Copyright: © Copyright © 2021 Salles, Perce-da-Silva, Rossi, Raposo, Ramirez Ramirez, Pereira Bastos, Pratt-Riccio, Cassiano, Baptista, Cardoso, Banic and Machado. |
| publishDate |
2021 |
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2021-07-23 2021-07-23T00:00:00Z 2022-02-17T23:18:43Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/133120 |
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http://hdl.handle.net/10362/133120 |
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eng |
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eng |
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1663-9812 PURE: 33793059 https://doi.org/10.3389/fphar.2021.542342 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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