CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.3389/fphar.2021.542342 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/50845 |
Resumo: | Universidade Federal Fluminense. Centro de Investigação de Microrganismos. Niterói, RJ, Brasil. |
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Salles, Paula FerreiraSilva, Daiana Souza Perce daRossi, Atila DuqueRaposo, Luisa RiehlRamirez, Aina Danaisa RamirezBastos, Otílio Machado PereiraPratt-Riccio, Lilian RoseCassiano, Gustavo CapattiBaptista, Andrea Regina SouzaCardoso, Cynthia ChesterBanic, Dalma MariaMachado, Ricardo Luiz Dantas2022-01-21T14:37:02Z2022-01-21T14:37:02Z2021SALLES, Paula Ferreira et al. CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region. Frontiers in Pharmacology, v. 12, Article 542342, p. 1 - 8, July 2021.1663-9812https://www.arca.fiocruz.br/handle/icict/5084510.3389/fphar.2021.542342engFrontiers MediaCYP2D6FarmacogenéticaPrimaquinaPlasmodium vivaxPolimorfismo genéticoRecaídasAmazônia brasileiraÁreas endêmicasPharmacogeneticsCYP2D6PrimaquinePlasmodium vivaxGenetic polymorphismRelapsesBrazilian Amazon regionEndemic AreasCYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Regioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal Fluminense. Centro de Investigação de Microrganismos. Niterói, RJ, Brasil.Faculdade de Medicina de Petrópolis. Petrópolis, RJ, Brasil.Universidade Federal do Rio de Janeiro. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Centro de Investigação de Microrganismos. Niterói, RJ, Brasil.Universidade Federal Fluminense. Centro de Investigação de Microrganismos. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Malária. Rio de Janeiro, RJ, Brasil.Universidade de Lisboa. Instituto de Higiene e Medicina Tropical. Saúde Global e Medicina Tropical. Lisboa, Portugal.Universidade Federal Fluminense. Centro de Investigação de Microrganismos. Niterói, RJ, Brasil.Universidade Federal do Rio de Janeiro. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Centro de Investigação de Microrganismos. Niterói, RJ, Brasil.Genetic variability was linked with individual responses to treatment and susceptibility to malaria by Plasmodium vivax. Polymorphisms in the CYP2D6 gene may modulate enzyme level and activity, thereby affecting individual responses to pharmacological treatment. The aim of the study was to investigate whether or not CYP2D6 single nucleotide polymorphisms rs1065852, rs38920-97, rs16947 and rs28371725 are unequally distributed in malaria by Plasmodium vivax individuals from the Brazilian Amazon region. The blood samples were collected from 220 unrelated Plasmodium vivax patients from five different endemic areas. Genotyping was performed using SNaPshot® and real-time polymerase chain reaction methods. In all five areas, the rs1065852 (CYP2D6*10, C.100C > T), rs3892097 (CYP2D6*4, 1846C > T) and rs16947 (CYP2D6*2, C.2850G > A), as a homozygous genotype, showed the lowest frequencies. The rs28371725 (CYP2D6*41, 2988G > A) homozygous genotype was not detected, while the allele A was found in a single patient fromMacapá region. No deviations from Hardy-Weinberg equilibrium were found, although a borderline p-value was observed (p 0.048) for the SNP rs3892097 in Goianésia do Pará, Pará state. No significant associations were detected in these frequencies among the five studied areas. For the SNP rs3892097, a higher frequency was observed for the C/T heterozygous genotype in the Plácido de Castro and Macapá, Acre and Amapá states, respectively. The distribution of the CYP2D6 alleles investigated in the different areas of the Brazilian Amazon is not homogeneous. Further investigations are necessary in order to determine which alleles might be informative to assure optimal drug dosing recommendations based on experimental pharmacogenetics.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/50845/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLilianRiccio_DalmaBanic_etal_IOC_2021.pdfLilianRiccio_DalmaBanic_etal_IOC_2021.pdfapplication/pdf796124https://www.arca.fiocruz.br/bitstream/icict/50845/2/LilianRiccio_DalmaBanic_etal_IOC_2021.pdf21635244485a66631164cd94628d610eMD52icict/508452022-01-21 11:37:02.133oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-01-21T14:37:02Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region |
| title |
CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region |
| spellingShingle |
CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region Salles, Paula Ferreira CYP2D6 Farmacogenética Primaquina Plasmodium vivax Polimorfismo genético Recaídas Amazônia brasileira Áreas endêmicas Pharmacogenetics CYP2D6 Primaquine Plasmodium vivax Genetic polymorphism Relapses Brazilian Amazon region Endemic Areas |
| title_short |
CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region |
| title_full |
CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region |
| title_fullStr |
CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region |
| title_full_unstemmed |
CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region |
| title_sort |
CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region |
| author |
Salles, Paula Ferreira |
| author_facet |
Salles, Paula Ferreira Silva, Daiana Souza Perce da Rossi, Atila Duque Raposo, Luisa Riehl Ramirez, Aina Danaisa Ramirez Bastos, Otílio Machado Pereira Pratt-Riccio, Lilian Rose Cassiano, Gustavo Capatti Baptista, Andrea Regina Souza Cardoso, Cynthia Chester Banic, Dalma Maria Machado, Ricardo Luiz Dantas |
| author_role |
author |
| author2 |
Silva, Daiana Souza Perce da Rossi, Atila Duque Raposo, Luisa Riehl Ramirez, Aina Danaisa Ramirez Bastos, Otílio Machado Pereira Pratt-Riccio, Lilian Rose Cassiano, Gustavo Capatti Baptista, Andrea Regina Souza Cardoso, Cynthia Chester Banic, Dalma Maria Machado, Ricardo Luiz Dantas |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Salles, Paula Ferreira Silva, Daiana Souza Perce da Rossi, Atila Duque Raposo, Luisa Riehl Ramirez, Aina Danaisa Ramirez Bastos, Otílio Machado Pereira Pratt-Riccio, Lilian Rose Cassiano, Gustavo Capatti Baptista, Andrea Regina Souza Cardoso, Cynthia Chester Banic, Dalma Maria Machado, Ricardo Luiz Dantas |
| dc.subject.other.pt_BR.fl_str_mv |
CYP2D6 Farmacogenética Primaquina Plasmodium vivax Polimorfismo genético Recaídas Amazônia brasileira Áreas endêmicas |
| topic |
CYP2D6 Farmacogenética Primaquina Plasmodium vivax Polimorfismo genético Recaídas Amazônia brasileira Áreas endêmicas Pharmacogenetics CYP2D6 Primaquine Plasmodium vivax Genetic polymorphism Relapses Brazilian Amazon region Endemic Areas |
| dc.subject.en.pt_BR.fl_str_mv |
Pharmacogenetics CYP2D6 Primaquine Plasmodium vivax Genetic polymorphism Relapses Brazilian Amazon region Endemic Areas |
| description |
Universidade Federal Fluminense. Centro de Investigação de Microrganismos. Niterói, RJ, Brasil. |
| publishDate |
2021 |
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2021 |
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2022-01-21T14:37:02Z |
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2022-01-21T14:37:02Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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SALLES, Paula Ferreira et al. CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region. Frontiers in Pharmacology, v. 12, Article 542342, p. 1 - 8, July 2021. |
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https://www.arca.fiocruz.br/handle/icict/50845 |
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1663-9812 |
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10.3389/fphar.2021.542342 |
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SALLES, Paula Ferreira et al. CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region. Frontiers in Pharmacology, v. 12, Article 542342, p. 1 - 8, July 2021. 1663-9812 10.3389/fphar.2021.542342 |
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