Sustained remission from depressive-like behavior depends on hippocampal neurogenesis

Detalhes bibliográficos
Autor(a) principal: Pinheiro, António Mateus
Data de Publicação: 2013
Outros Autores: Pinto, Luísa, Bessa, J. M., Morais, Mónica, Alves, N. D., Monteiro, S., Patrício, P., Almeida, O. F. X., Sousa, Nuno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/24154
Resumo: Impairment of hippocampal neurogenesis has been associated with the expression of depressive-like symptoms and some studies have suggested neurogenesis as a critical factor in the normalization of behavior by antidepressant (AD) drugs. This study provides robust evidence that ongoing neurogenesis is essential for the maintenance of behavioral homeostasis and that its pharmacological arrest precipitates symptoms commonly found in depressed patients. Further, the incorporation of newly born neurons and astrocytes into the preexisting hippocampal neurocircuitry is shown to be necessary for the spontaneous recovery from the adverse effects of stress and for long-term benefits of AD treatments.
id RCAP_405e419672a6c4792912e4faa6f9b1f7
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/24154
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Sustained remission from depressive-like behavior depends on hippocampal neurogenesisAntidepressantDepressionGliogenesisNeurogenesisStressScience & TechnologyImpairment of hippocampal neurogenesis has been associated with the expression of depressive-like symptoms and some studies have suggested neurogenesis as a critical factor in the normalization of behavior by antidepressant (AD) drugs. This study provides robust evidence that ongoing neurogenesis is essential for the maintenance of behavioral homeostasis and that its pharmacological arrest precipitates symptoms commonly found in depressed patients. Further, the incorporation of newly born neurons and astrocytes into the preexisting hippocampal neurocircuitry is shown to be necessary for the spontaneous recovery from the adverse effects of stress and for long-term benefits of AD treatments.We thank M Carneiro and L Martins for technical assistance. AM-P, LP, MM and SM received fellowships from the Portuguese Foundation for Science and Technology (FCT). This work was supported by FCT (PTDC/SAU-NEU/105180/2008) and the ICVS.Nature Publishing GroupUniversidade do MinhoPinheiro, António MateusPinto, LuísaBessa, J. M.Morais, MónicaAlves, N. D.Monteiro, S.Patrício, P.Almeida, O. F. X.Sousa, Nuno2013-012013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/24154engTranslational Psychiatry (2013) 3, e210; doi:10.1038/tp.2012.1412158-318810.1038/tp.2012.14123321807http://dx.doi.org/10.1038/tp.2012.141info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:16:14Zoai:repositorium.sdum.uminho.pt:1822/24154Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:08:45.109759Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Sustained remission from depressive-like behavior depends on hippocampal neurogenesis
title Sustained remission from depressive-like behavior depends on hippocampal neurogenesis
spellingShingle Sustained remission from depressive-like behavior depends on hippocampal neurogenesis
Pinheiro, António Mateus
Antidepressant
Depression
Gliogenesis
Neurogenesis
Stress
Science & Technology
title_short Sustained remission from depressive-like behavior depends on hippocampal neurogenesis
title_full Sustained remission from depressive-like behavior depends on hippocampal neurogenesis
title_fullStr Sustained remission from depressive-like behavior depends on hippocampal neurogenesis
title_full_unstemmed Sustained remission from depressive-like behavior depends on hippocampal neurogenesis
title_sort Sustained remission from depressive-like behavior depends on hippocampal neurogenesis
author Pinheiro, António Mateus
author_facet Pinheiro, António Mateus
Pinto, Luísa
Bessa, J. M.
Morais, Mónica
Alves, N. D.
Monteiro, S.
Patrício, P.
Almeida, O. F. X.
Sousa, Nuno
author_role author
author2 Pinto, Luísa
Bessa, J. M.
Morais, Mónica
Alves, N. D.
Monteiro, S.
Patrício, P.
Almeida, O. F. X.
Sousa, Nuno
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Pinheiro, António Mateus
Pinto, Luísa
Bessa, J. M.
Morais, Mónica
Alves, N. D.
Monteiro, S.
Patrício, P.
Almeida, O. F. X.
Sousa, Nuno
dc.subject.por.fl_str_mv Antidepressant
Depression
Gliogenesis
Neurogenesis
Stress
Science & Technology
topic Antidepressant
Depression
Gliogenesis
Neurogenesis
Stress
Science & Technology
description Impairment of hippocampal neurogenesis has been associated with the expression of depressive-like symptoms and some studies have suggested neurogenesis as a critical factor in the normalization of behavior by antidepressant (AD) drugs. This study provides robust evidence that ongoing neurogenesis is essential for the maintenance of behavioral homeostasis and that its pharmacological arrest precipitates symptoms commonly found in depressed patients. Further, the incorporation of newly born neurons and astrocytes into the preexisting hippocampal neurocircuitry is shown to be necessary for the spontaneous recovery from the adverse effects of stress and for long-term benefits of AD treatments.
publishDate 2013
dc.date.none.fl_str_mv 2013-01
2013-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/24154
url http://hdl.handle.net/1822/24154
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Translational Psychiatry (2013) 3, e210; doi:10.1038/tp.2012.141
2158-3188
10.1038/tp.2012.141
23321807
http://dx.doi.org/10.1038/tp.2012.141
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132510400020480

Registros relacionados