Sustained remission from depressive-like behavior depends on hippocampal neurogenesis
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/24154 |
Resumo: | Impairment of hippocampal neurogenesis has been associated with the expression of depressive-like symptoms and some studies have suggested neurogenesis as a critical factor in the normalization of behavior by antidepressant (AD) drugs. This study provides robust evidence that ongoing neurogenesis is essential for the maintenance of behavioral homeostasis and that its pharmacological arrest precipitates symptoms commonly found in depressed patients. Further, the incorporation of newly born neurons and astrocytes into the preexisting hippocampal neurocircuitry is shown to be necessary for the spontaneous recovery from the adverse effects of stress and for long-term benefits of AD treatments. |
id |
RCAP_405e419672a6c4792912e4faa6f9b1f7 |
---|---|
oai_identifier_str |
oai:repositorium.sdum.uminho.pt:1822/24154 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Sustained remission from depressive-like behavior depends on hippocampal neurogenesisAntidepressantDepressionGliogenesisNeurogenesisStressScience & TechnologyImpairment of hippocampal neurogenesis has been associated with the expression of depressive-like symptoms and some studies have suggested neurogenesis as a critical factor in the normalization of behavior by antidepressant (AD) drugs. This study provides robust evidence that ongoing neurogenesis is essential for the maintenance of behavioral homeostasis and that its pharmacological arrest precipitates symptoms commonly found in depressed patients. Further, the incorporation of newly born neurons and astrocytes into the preexisting hippocampal neurocircuitry is shown to be necessary for the spontaneous recovery from the adverse effects of stress and for long-term benefits of AD treatments.We thank M Carneiro and L Martins for technical assistance. AM-P, LP, MM and SM received fellowships from the Portuguese Foundation for Science and Technology (FCT). This work was supported by FCT (PTDC/SAU-NEU/105180/2008) and the ICVS.Nature Publishing GroupUniversidade do MinhoPinheiro, António MateusPinto, LuísaBessa, J. M.Morais, MónicaAlves, N. D.Monteiro, S.Patrício, P.Almeida, O. F. X.Sousa, Nuno2013-012013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/24154engTranslational Psychiatry (2013) 3, e210; doi:10.1038/tp.2012.1412158-318810.1038/tp.2012.14123321807http://dx.doi.org/10.1038/tp.2012.141info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:16:14Zoai:repositorium.sdum.uminho.pt:1822/24154Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:08:45.109759Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Sustained remission from depressive-like behavior depends on hippocampal neurogenesis |
title |
Sustained remission from depressive-like behavior depends on hippocampal neurogenesis |
spellingShingle |
Sustained remission from depressive-like behavior depends on hippocampal neurogenesis Pinheiro, António Mateus Antidepressant Depression Gliogenesis Neurogenesis Stress Science & Technology |
title_short |
Sustained remission from depressive-like behavior depends on hippocampal neurogenesis |
title_full |
Sustained remission from depressive-like behavior depends on hippocampal neurogenesis |
title_fullStr |
Sustained remission from depressive-like behavior depends on hippocampal neurogenesis |
title_full_unstemmed |
Sustained remission from depressive-like behavior depends on hippocampal neurogenesis |
title_sort |
Sustained remission from depressive-like behavior depends on hippocampal neurogenesis |
author |
Pinheiro, António Mateus |
author_facet |
Pinheiro, António Mateus Pinto, Luísa Bessa, J. M. Morais, Mónica Alves, N. D. Monteiro, S. Patrício, P. Almeida, O. F. X. Sousa, Nuno |
author_role |
author |
author2 |
Pinto, Luísa Bessa, J. M. Morais, Mónica Alves, N. D. Monteiro, S. Patrício, P. Almeida, O. F. X. Sousa, Nuno |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Pinheiro, António Mateus Pinto, Luísa Bessa, J. M. Morais, Mónica Alves, N. D. Monteiro, S. Patrício, P. Almeida, O. F. X. Sousa, Nuno |
dc.subject.por.fl_str_mv |
Antidepressant Depression Gliogenesis Neurogenesis Stress Science & Technology |
topic |
Antidepressant Depression Gliogenesis Neurogenesis Stress Science & Technology |
description |
Impairment of hippocampal neurogenesis has been associated with the expression of depressive-like symptoms and some studies have suggested neurogenesis as a critical factor in the normalization of behavior by antidepressant (AD) drugs. This study provides robust evidence that ongoing neurogenesis is essential for the maintenance of behavioral homeostasis and that its pharmacological arrest precipitates symptoms commonly found in depressed patients. Further, the incorporation of newly born neurons and astrocytes into the preexisting hippocampal neurocircuitry is shown to be necessary for the spontaneous recovery from the adverse effects of stress and for long-term benefits of AD treatments. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-01 2013-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/24154 |
url |
http://hdl.handle.net/1822/24154 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Translational Psychiatry (2013) 3, e210; doi:10.1038/tp.2012.141 2158-3188 10.1038/tp.2012.141 23321807 http://dx.doi.org/10.1038/tp.2012.141 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799132510400020480 |