Cell non-autonomous proteostasis regulation in aging and disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/143972 |
Resumo: | Funding: This study was supported by the “Programa Operacional Regional de Lisboa-FEDER/ Project 02/SAICT/2020/072552,” and iNOVA4Health – UIDB/04462/2020 and UIDP/04462/2020, and by the Associated Laboratory LS4FUTURE (LA/P/0087/2020), two programs financially supported by Fundação para a Ciência e Tecnologia / Ministério da Ciência, Tecnologia e Ensino Superior. |
| id |
RCAP_d5fa25b290b8149d7b377535b8a25ea2 |
|---|---|
| oai_identifier_str |
oai:run.unl.pt:10362/143972 |
| network_acronym_str |
RCAP |
| network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository_id_str |
7160 |
| spelling |
Cell non-autonomous proteostasis regulation in aging and diseasemisfoldingmolecular chaperonesproteostasisproteotoxicitytranscellularFunding: This study was supported by the “Programa Operacional Regional de Lisboa-FEDER/ Project 02/SAICT/2020/072552,” and iNOVA4Health – UIDB/04462/2020 and UIDP/04462/2020, and by the Associated Laboratory LS4FUTURE (LA/P/0087/2020), two programs financially supported by Fundação para a Ciência e Tecnologia / Ministério da Ciência, Tecnologia e Ensino Superior.Aging is a risk factor for a number of diseases, being the more notorious ones perhaps neurodegenerative diseases such as Alzheimer's and Parkinson's. These and other age-related pathologies are often associated with accumulation of proteotoxic material inside cells, as well as with the accumulation of protein deposits extracellularly. It is widely accepted that this accumulation of toxic proteins trails a progressive decline in the mechanisms that regulate protein homeostasis, or proteostasis, during aging. However, despite significant efforts, the progress in terms of novel or improved therapies targeting accumulation of proteotoxic material has been rather limited. For example, clinical trials for new drugs aimed at treating Alzheimer's disease, by preventing accumulation of toxic proteins, have notoriously failed. On the other hand, it is becoming increasingly apparent that regulation of proteostasis is not a cell autonomous process. In fact, cells rely on complex transcellular networks to maintain tissue and organ homeostasis involving endocrine and paracrine signaling pathways. In this review we will discuss the impact of cell non-autonomous proteostasis mechanisms and their impact in aging and disease. We will focus on how transcellular proteostasis networks can shed new light into stablished paradigms about the aging of organisms.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNFerreira, Joao Vascoda Rosa Soares, AnaPereira, Paulo2022-09-22T22:37:30Z2022-06-092022-06-09T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/143972eng1662-4548PURE: 46538098https://doi.org/10.3389/fnins.2022.878296info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:23:02Zoai:run.unl.pt:10362/143972Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:51:15.180181Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Cell non-autonomous proteostasis regulation in aging and disease |
| title |
Cell non-autonomous proteostasis regulation in aging and disease |
| spellingShingle |
Cell non-autonomous proteostasis regulation in aging and disease Ferreira, Joao Vasco misfolding molecular chaperones proteostasis proteotoxicity transcellular |
| title_short |
Cell non-autonomous proteostasis regulation in aging and disease |
| title_full |
Cell non-autonomous proteostasis regulation in aging and disease |
| title_fullStr |
Cell non-autonomous proteostasis regulation in aging and disease |
| title_full_unstemmed |
Cell non-autonomous proteostasis regulation in aging and disease |
| title_sort |
Cell non-autonomous proteostasis regulation in aging and disease |
| author |
Ferreira, Joao Vasco |
| author_facet |
Ferreira, Joao Vasco da Rosa Soares, Ana Pereira, Paulo |
| author_role |
author |
| author2 |
da Rosa Soares, Ana Pereira, Paulo |
| author2_role |
author author |
| dc.contributor.none.fl_str_mv |
Centro de Estudos de Doenças Crónicas (CEDOC) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Ferreira, Joao Vasco da Rosa Soares, Ana Pereira, Paulo |
| dc.subject.por.fl_str_mv |
misfolding molecular chaperones proteostasis proteotoxicity transcellular |
| topic |
misfolding molecular chaperones proteostasis proteotoxicity transcellular |
| description |
Funding: This study was supported by the “Programa Operacional Regional de Lisboa-FEDER/ Project 02/SAICT/2020/072552,” and iNOVA4Health – UIDB/04462/2020 and UIDP/04462/2020, and by the Associated Laboratory LS4FUTURE (LA/P/0087/2020), two programs financially supported by Fundação para a Ciência e Tecnologia / Ministério da Ciência, Tecnologia e Ensino Superior. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-09-22T22:37:30Z 2022-06-09 2022-06-09T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/143972 |
| url |
http://hdl.handle.net/10362/143972 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1662-4548 PURE: 46538098 https://doi.org/10.3389/fnins.2022.878296 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
| instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| repository.mail.fl_str_mv |
|
| _version_ |
1799138107343241216 |