Collagen and microvascularization in placentas from young and older mares

Detalhes bibliográficos
Autor(a) principal: Silva, Ana Catarina Neto
Data de Publicação: 2022
Outros Autores: Costa, Ana Luísa, Teixeira, Ana, Alpoim-moreira, Joana, Fernandes, Carina, Fradinho, M.J., Rebordão, Maria Rosa, Silva, Elisabete, Ferreira da Silva, José, Bliebernicht, Miguel, Alexandre-Pires, Graça, Ferreira-Dias, Graça
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/24148
Resumo: Research Areas: Veterinary Sciences
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spelling Collagen and microvascularization in placentas from young and older maresCollagenFibrosisPlacentaAgeMareFoalMicrovascularizationGestationResearch Areas: Veterinary SciencesIn older mares, increasing collagen fibers (fibrosis) in the endometrium and oviduct predisposes to sub-fertility and infertility. In this study, (i) gene transcription of collagen (qPCR: COL1A1, COL1A2, COL3A1, COL5A1); (ii) total collagen protein (hydroxyproline); (iii) collagen distribution (Picrosirius red staining; polarized light microscopy); and (iv) microvascular density (Periodic acid-Schiff staining), were evaluated in mares’ placenta, and related to mares age, and placenta and neonate weights. Samples were collected from the gravid horn, non-gravid horn, and body of the placenta from younger (n = 7), and older mares (n = 9) of different breeds. Transcripts of COL1A1, COL3A1 and COL5A1, total collagen protein, chorionic plate connective tissue thickness, and microvascularization increased in the gravid horn of older mares’ placentas, compared to the youngest (P < 0.05). Although in other species placenta fibrosis may indicate placental insufficiency and reduced neonate weight, this was not observed here. It appears that older fertile mares, with more parities, may develop a heavier, more vascularized functional placenta with more collagen, throughout a longer gestation, which enables the delivery of heavier foals. Thus, these features might represent morphological and physiological adaptations of older fertile mares’ placentas to provide the appropriate nutrition to the equine fetus.Frontiers Media SARepositório da Universidade de LisboaSilva, Ana Catarina NetoCosta, Ana LuísaTeixeira, AnaAlpoim-moreira, JoanaFernandes, CarinaFradinho, M.J.Rebordão, Maria RosaSilva, ElisabeteFerreira da Silva, JoséBliebernicht, MiguelAlexandre-Pires, GraçaFerreira-Dias, Graça2022-04-23T00:08:46Z2022-01-042022-01-04T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/24148engNeto da Silva AC, Costa AL, Teixeira A, Alpoim-Moreira J, Fernandes C, Fradinho MJ, Rebordão MR, Silva E, Ferreira da Silva J, Bliebernicht M, Alexandre-Pires G and Ferreira-Dias G. 2022. Collagen and microvascularization in placentas from young and older mares. Frontiers in Veterinary Sciences, 8:772658. Doi: 10.3389/fvets.2021.77265810.3389/fvets.2021.7726582297-1769info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:53:48Zoai:www.repository.utl.pt:10400.5/24148Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:08:15.721250Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Collagen and microvascularization in placentas from young and older mares
title Collagen and microvascularization in placentas from young and older mares
spellingShingle Collagen and microvascularization in placentas from young and older mares
Silva, Ana Catarina Neto
Collagen
Fibrosis
Placenta
Age
Mare
Foal
Microvascularization
Gestation
title_short Collagen and microvascularization in placentas from young and older mares
title_full Collagen and microvascularization in placentas from young and older mares
title_fullStr Collagen and microvascularization in placentas from young and older mares
title_full_unstemmed Collagen and microvascularization in placentas from young and older mares
title_sort Collagen and microvascularization in placentas from young and older mares
author Silva, Ana Catarina Neto
author_facet Silva, Ana Catarina Neto
Costa, Ana Luísa
Teixeira, Ana
Alpoim-moreira, Joana
Fernandes, Carina
Fradinho, M.J.
Rebordão, Maria Rosa
Silva, Elisabete
Ferreira da Silva, José
Bliebernicht, Miguel
Alexandre-Pires, Graça
Ferreira-Dias, Graça
author_role author
author2 Costa, Ana Luísa
Teixeira, Ana
Alpoim-moreira, Joana
Fernandes, Carina
Fradinho, M.J.
Rebordão, Maria Rosa
Silva, Elisabete
Ferreira da Silva, José
Bliebernicht, Miguel
Alexandre-Pires, Graça
Ferreira-Dias, Graça
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Silva, Ana Catarina Neto
Costa, Ana Luísa
Teixeira, Ana
Alpoim-moreira, Joana
Fernandes, Carina
Fradinho, M.J.
Rebordão, Maria Rosa
Silva, Elisabete
Ferreira da Silva, José
Bliebernicht, Miguel
Alexandre-Pires, Graça
Ferreira-Dias, Graça
dc.subject.por.fl_str_mv Collagen
Fibrosis
Placenta
Age
Mare
Foal
Microvascularization
Gestation
topic Collagen
Fibrosis
Placenta
Age
Mare
Foal
Microvascularization
Gestation
description Research Areas: Veterinary Sciences
publishDate 2022
dc.date.none.fl_str_mv 2022-04-23T00:08:46Z
2022-01-04
2022-01-04T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/24148
url http://hdl.handle.net/10400.5/24148
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Neto da Silva AC, Costa AL, Teixeira A, Alpoim-Moreira J, Fernandes C, Fradinho MJ, Rebordão MR, Silva E, Ferreira da Silva J, Bliebernicht M, Alexandre-Pires G and Ferreira-Dias G. 2022. Collagen and microvascularization in placentas from young and older mares. Frontiers in Veterinary Sciences, 8:772658. Doi: 10.3389/fvets.2021.772658
10.3389/fvets.2021.772658
2297-1769
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media SA
publisher.none.fl_str_mv Frontiers Media SA
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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