Collagen and microvascularization in placentas from young and older mares
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.5/24148 |
Resumo: | Research Areas: Veterinary Sciences |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
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Collagen and microvascularization in placentas from young and older maresCollagenFibrosisPlacentaAgeMareFoalMicrovascularizationGestationResearch Areas: Veterinary SciencesIn older mares, increasing collagen fibers (fibrosis) in the endometrium and oviduct predisposes to sub-fertility and infertility. In this study, (i) gene transcription of collagen (qPCR: COL1A1, COL1A2, COL3A1, COL5A1); (ii) total collagen protein (hydroxyproline); (iii) collagen distribution (Picrosirius red staining; polarized light microscopy); and (iv) microvascular density (Periodic acid-Schiff staining), were evaluated in mares’ placenta, and related to mares age, and placenta and neonate weights. Samples were collected from the gravid horn, non-gravid horn, and body of the placenta from younger (n = 7), and older mares (n = 9) of different breeds. Transcripts of COL1A1, COL3A1 and COL5A1, total collagen protein, chorionic plate connective tissue thickness, and microvascularization increased in the gravid horn of older mares’ placentas, compared to the youngest (P < 0.05). Although in other species placenta fibrosis may indicate placental insufficiency and reduced neonate weight, this was not observed here. It appears that older fertile mares, with more parities, may develop a heavier, more vascularized functional placenta with more collagen, throughout a longer gestation, which enables the delivery of heavier foals. Thus, these features might represent morphological and physiological adaptations of older fertile mares’ placentas to provide the appropriate nutrition to the equine fetus.Frontiers Media SARepositório da Universidade de LisboaSilva, Ana Catarina NetoCosta, Ana LuísaTeixeira, AnaAlpoim-moreira, JoanaFernandes, CarinaFradinho, M.J.Rebordão, Maria RosaSilva, ElisabeteFerreira da Silva, JoséBliebernicht, MiguelAlexandre-Pires, GraçaFerreira-Dias, Graça2022-04-23T00:08:46Z2022-01-042022-01-04T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/24148engNeto da Silva AC, Costa AL, Teixeira A, Alpoim-Moreira J, Fernandes C, Fradinho MJ, Rebordão MR, Silva E, Ferreira da Silva J, Bliebernicht M, Alexandre-Pires G and Ferreira-Dias G. 2022. Collagen and microvascularization in placentas from young and older mares. Frontiers in Veterinary Sciences, 8:772658. Doi: 10.3389/fvets.2021.77265810.3389/fvets.2021.7726582297-1769info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:53:48Zoai:www.repository.utl.pt:10400.5/24148Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:08:15.721250Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Collagen and microvascularization in placentas from young and older mares |
title |
Collagen and microvascularization in placentas from young and older mares |
spellingShingle |
Collagen and microvascularization in placentas from young and older mares Silva, Ana Catarina Neto Collagen Fibrosis Placenta Age Mare Foal Microvascularization Gestation |
title_short |
Collagen and microvascularization in placentas from young and older mares |
title_full |
Collagen and microvascularization in placentas from young and older mares |
title_fullStr |
Collagen and microvascularization in placentas from young and older mares |
title_full_unstemmed |
Collagen and microvascularization in placentas from young and older mares |
title_sort |
Collagen and microvascularization in placentas from young and older mares |
author |
Silva, Ana Catarina Neto |
author_facet |
Silva, Ana Catarina Neto Costa, Ana Luísa Teixeira, Ana Alpoim-moreira, Joana Fernandes, Carina Fradinho, M.J. Rebordão, Maria Rosa Silva, Elisabete Ferreira da Silva, José Bliebernicht, Miguel Alexandre-Pires, Graça Ferreira-Dias, Graça |
author_role |
author |
author2 |
Costa, Ana Luísa Teixeira, Ana Alpoim-moreira, Joana Fernandes, Carina Fradinho, M.J. Rebordão, Maria Rosa Silva, Elisabete Ferreira da Silva, José Bliebernicht, Miguel Alexandre-Pires, Graça Ferreira-Dias, Graça |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Silva, Ana Catarina Neto Costa, Ana Luísa Teixeira, Ana Alpoim-moreira, Joana Fernandes, Carina Fradinho, M.J. Rebordão, Maria Rosa Silva, Elisabete Ferreira da Silva, José Bliebernicht, Miguel Alexandre-Pires, Graça Ferreira-Dias, Graça |
dc.subject.por.fl_str_mv |
Collagen Fibrosis Placenta Age Mare Foal Microvascularization Gestation |
topic |
Collagen Fibrosis Placenta Age Mare Foal Microvascularization Gestation |
description |
Research Areas: Veterinary Sciences |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-23T00:08:46Z 2022-01-04 2022-01-04T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.5/24148 |
url |
http://hdl.handle.net/10400.5/24148 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Neto da Silva AC, Costa AL, Teixeira A, Alpoim-Moreira J, Fernandes C, Fradinho MJ, Rebordão MR, Silva E, Ferreira da Silva J, Bliebernicht M, Alexandre-Pires G and Ferreira-Dias G. 2022. Collagen and microvascularization in placentas from young and older mares. Frontiers in Veterinary Sciences, 8:772658. Doi: 10.3389/fvets.2021.772658 10.3389/fvets.2021.772658 2297-1769 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media SA |
publisher.none.fl_str_mv |
Frontiers Media SA |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1817550796988874752 |