Ionogels Derived from Fluorinated Ionic Liquids to Enhance Aqueous Drug Solubility for Local Drug Administration
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/145846 |
Resumo: | Publisher Copyright: © 2022 by the authors. |
| id |
RCAP_4230e28776898f162afae7312e8b5575 |
|---|---|
| oai_identifier_str |
oai:run.unl.pt:10362/145846 |
| network_acronym_str |
RCAP |
| network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository_id_str |
7160 |
| spelling |
Ionogels Derived from Fluorinated Ionic Liquids to Enhance Aqueous Drug Solubility for Local Drug Administration1-ethyl-3-methylpyridinium perfluorobutanesulfonatedrug deliveryemulsionsgelatinBioengineeringBiomaterialsOrganic ChemistryPolymers and PlasticsPublisher Copyright: © 2022 by the authors.Gelatin is a popular biopolymer for biomedical applications due to its harmless impact with a negligible inflammatory response in the host organism. Gelatin interacts with soluble molecules in aqueous media as ionic counterparts such as ionic liquids (ILs) to be used as cosolvents to generate the so-called Ionogels. The perfluorinated IL (FIL), 1-ethyl-3-methylpyridinium perfluorobutanesulfonate, has been selected as co-hydrosolvent for fish gelatin due to its low cytotoxicity and hydrophobicity aprotic polar structure to improve the drug aqueous solubility. A series of FIL/water emulsions with different FIL content and their corresponding shark gelatin/FIL Ionogel has been designed to enhance the drug solubility whilst retaining the mechanical structure and their nanostructure was probed by simultaneous SAXS/WAXS, FTIR and Raman spectroscopy, DSC and rheological experiments. Likewise, the FIL assisted the solubility of the antitumoural Doxorubicin whilst retaining the performing mechanical properties of the drug delivery system network for the drug storage as well as the local administration by a syringe. In addition, the different controlled release mechanisms of two different antitumoral such as Doxorubicin and Mithramycin from two different Ionogels formulations were compared to previous gelatin hydrogels which proved the key structure correlation required to attain specific therapeutic dosages.LAQV@REQUIMTEDQ - Departamento de QuímicaRUNHermida-Merino, CarolinaCabaleiro, DavidGracia-Fernández, CarlosValcarcel, JesusVázquez, José AntonioSanz, NoeliaPérez-Rodríguez, MartínArenas-Moreira, MariaBanerjee, DipanjanLongo, AlessandroMoya-Lopez, CarmenLugo, LuisBourson, PatricePereiro, Ana B.Salloum-Abou-Jaoude, GeorgesBravo, IvánPiñeiro, Manuel M.Hermida-Merino, Daniel2022-11-28T22:14:23Z2022-092022-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article32application/pdfhttp://hdl.handle.net/10362/145846eng2310-2861PURE: 47179485https://doi.org/10.3390/gels8090594info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:26:31Zoai:run.unl.pt:10362/145846Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:52:17.630738Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Ionogels Derived from Fluorinated Ionic Liquids to Enhance Aqueous Drug Solubility for Local Drug Administration |
| title |
Ionogels Derived from Fluorinated Ionic Liquids to Enhance Aqueous Drug Solubility for Local Drug Administration |
| spellingShingle |
Ionogels Derived from Fluorinated Ionic Liquids to Enhance Aqueous Drug Solubility for Local Drug Administration Hermida-Merino, Carolina 1-ethyl-3-methylpyridinium perfluorobutanesulfonate drug delivery emulsions gelatin Bioengineering Biomaterials Organic Chemistry Polymers and Plastics |
| title_short |
Ionogels Derived from Fluorinated Ionic Liquids to Enhance Aqueous Drug Solubility for Local Drug Administration |
| title_full |
Ionogels Derived from Fluorinated Ionic Liquids to Enhance Aqueous Drug Solubility for Local Drug Administration |
| title_fullStr |
Ionogels Derived from Fluorinated Ionic Liquids to Enhance Aqueous Drug Solubility for Local Drug Administration |
| title_full_unstemmed |
Ionogels Derived from Fluorinated Ionic Liquids to Enhance Aqueous Drug Solubility for Local Drug Administration |
| title_sort |
Ionogels Derived from Fluorinated Ionic Liquids to Enhance Aqueous Drug Solubility for Local Drug Administration |
| author |
Hermida-Merino, Carolina |
| author_facet |
Hermida-Merino, Carolina Cabaleiro, David Gracia-Fernández, Carlos Valcarcel, Jesus Vázquez, José Antonio Sanz, Noelia Pérez-Rodríguez, Martín Arenas-Moreira, Maria Banerjee, Dipanjan Longo, Alessandro Moya-Lopez, Carmen Lugo, Luis Bourson, Patrice Pereiro, Ana B. Salloum-Abou-Jaoude, Georges Bravo, Iván Piñeiro, Manuel M. Hermida-Merino, Daniel |
| author_role |
author |
| author2 |
Cabaleiro, David Gracia-Fernández, Carlos Valcarcel, Jesus Vázquez, José Antonio Sanz, Noelia Pérez-Rodríguez, Martín Arenas-Moreira, Maria Banerjee, Dipanjan Longo, Alessandro Moya-Lopez, Carmen Lugo, Luis Bourson, Patrice Pereiro, Ana B. Salloum-Abou-Jaoude, Georges Bravo, Iván Piñeiro, Manuel M. Hermida-Merino, Daniel |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
LAQV@REQUIMTE DQ - Departamento de Química RUN |
| dc.contributor.author.fl_str_mv |
Hermida-Merino, Carolina Cabaleiro, David Gracia-Fernández, Carlos Valcarcel, Jesus Vázquez, José Antonio Sanz, Noelia Pérez-Rodríguez, Martín Arenas-Moreira, Maria Banerjee, Dipanjan Longo, Alessandro Moya-Lopez, Carmen Lugo, Luis Bourson, Patrice Pereiro, Ana B. Salloum-Abou-Jaoude, Georges Bravo, Iván Piñeiro, Manuel M. Hermida-Merino, Daniel |
| dc.subject.por.fl_str_mv |
1-ethyl-3-methylpyridinium perfluorobutanesulfonate drug delivery emulsions gelatin Bioengineering Biomaterials Organic Chemistry Polymers and Plastics |
| topic |
1-ethyl-3-methylpyridinium perfluorobutanesulfonate drug delivery emulsions gelatin Bioengineering Biomaterials Organic Chemistry Polymers and Plastics |
| description |
Publisher Copyright: © 2022 by the authors. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-11-28T22:14:23Z 2022-09 2022-09-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/145846 |
| url |
http://hdl.handle.net/10362/145846 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2310-2861 PURE: 47179485 https://doi.org/10.3390/gels8090594 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
32 application/pdf |
| dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
| instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| repository.mail.fl_str_mv |
|
| _version_ |
1799138114444197888 |