A systematic review of behavioral, physiological, and neurobiological cognitive regulation alterations in obsessive-compulsive disorder

Detalhes bibliográficos
Autor(a) principal: Ferreira, Sónia
Data de Publicação: 2020
Outros Autores: Pêgo, José M., Morgado, Pedro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/68715
Resumo: Obsessive-compulsive disorder (OCD) is characterized by cognitive regulation deficits. However, the current literature has focused on executive functioning and emotional response impairments in this disorder. Herein, we conducted a systematic review of studies assessing the behavioral, physiological, and neurobiological alterations in cognitive regulation in obsessive-compulsive patients using the PubMed database. Most of the studies included explored behavioral (distress, arousal, and frequency of intrusive thoughts) and neurobiological measures (brain activity and functional connectivity) using affective cognitive regulation paradigms. Our results pointed to the advantageous use of reappraisal and acceptance strategies in contrast to suppression to reduce distress and frequency of intrusive thoughts. Moreover, we observed alterations in frontoparietal network activity during cognitive regulation. Our conclusions are limited by the inclusion of underpowered studies with treated patients. Nonetheless, our findings support the OCD impairments in cognitive regulation of emotion and might help to improve current guidelines for cognitive therapy.
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spelling A systematic review of behavioral, physiological, and neurobiological cognitive regulation alterations in obsessive-compulsive disorderOCDobsessive-compulsiveemotionsuppressionreappraisalfMRICiências Médicas::Ciências da SaúdeScience & TechnologyObsessive-compulsive disorder (OCD) is characterized by cognitive regulation deficits. However, the current literature has focused on executive functioning and emotional response impairments in this disorder. Herein, we conducted a systematic review of studies assessing the behavioral, physiological, and neurobiological alterations in cognitive regulation in obsessive-compulsive patients using the PubMed database. Most of the studies included explored behavioral (distress, arousal, and frequency of intrusive thoughts) and neurobiological measures (brain activity and functional connectivity) using affective cognitive regulation paradigms. Our results pointed to the advantageous use of reappraisal and acceptance strategies in contrast to suppression to reduce distress and frequency of intrusive thoughts. Moreover, we observed alterations in frontoparietal network activity during cognitive regulation. Our conclusions are limited by the inclusion of underpowered studies with treated patients. Nonetheless, our findings support the OCD impairments in cognitive regulation of emotion and might help to improve current guidelines for cognitive therapy.This work has been funded by national funds, through the Foundation for Science and Technology (FCT)—project UIDB/50026/2020 and UIDP/50026/2020—and by the projects NORTE-01-0145-FEDER-000013 and NORTE-01-0145-FEDER-000023, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). S.F. was supported by a combined Ph.D. scholarship from the FCT and the company iCognitus4ALL—IT Solutions, Lda (grant number PD/BDE/127839/2016). The funding sources had not been involved in the study design, the collection, analysis, and interpretation of data, in the writing of the report, and in the decision to submit the article for publication.Multidisciplinary Digital Publishing InstituteUniversidade do MinhoFerreira, SóniaPêgo, José M.Morgado, Pedro2020-102020-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/68715engFerreira, S.; Pêgo, J.M.; Morgado, P. A Systematic Review of Behavioral, Physiological, and Neurobiological Cognitive Regulation Alterations in Obsessive-Compulsive Disorder. Brain Sci. 2020, 10, 797. DOI: 10.3390/brainsci101107972076-342510.3390/brainsci10110797https://www.mdpi.com/2076-3425/10/11/797info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:27:13Zoai:repositorium.sdum.uminho.pt:1822/68715Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:21:45.436998Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A systematic review of behavioral, physiological, and neurobiological cognitive regulation alterations in obsessive-compulsive disorder
title A systematic review of behavioral, physiological, and neurobiological cognitive regulation alterations in obsessive-compulsive disorder
spellingShingle A systematic review of behavioral, physiological, and neurobiological cognitive regulation alterations in obsessive-compulsive disorder
Ferreira, Sónia
OCD
obsessive-compulsive
emotion
suppression
reappraisal
fMRI
Ciências Médicas::Ciências da Saúde
Science & Technology
title_short A systematic review of behavioral, physiological, and neurobiological cognitive regulation alterations in obsessive-compulsive disorder
title_full A systematic review of behavioral, physiological, and neurobiological cognitive regulation alterations in obsessive-compulsive disorder
title_fullStr A systematic review of behavioral, physiological, and neurobiological cognitive regulation alterations in obsessive-compulsive disorder
title_full_unstemmed A systematic review of behavioral, physiological, and neurobiological cognitive regulation alterations in obsessive-compulsive disorder
title_sort A systematic review of behavioral, physiological, and neurobiological cognitive regulation alterations in obsessive-compulsive disorder
author Ferreira, Sónia
author_facet Ferreira, Sónia
Pêgo, José M.
Morgado, Pedro
author_role author
author2 Pêgo, José M.
Morgado, Pedro
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Ferreira, Sónia
Pêgo, José M.
Morgado, Pedro
dc.subject.por.fl_str_mv OCD
obsessive-compulsive
emotion
suppression
reappraisal
fMRI
Ciências Médicas::Ciências da Saúde
Science & Technology
topic OCD
obsessive-compulsive
emotion
suppression
reappraisal
fMRI
Ciências Médicas::Ciências da Saúde
Science & Technology
description Obsessive-compulsive disorder (OCD) is characterized by cognitive regulation deficits. However, the current literature has focused on executive functioning and emotional response impairments in this disorder. Herein, we conducted a systematic review of studies assessing the behavioral, physiological, and neurobiological alterations in cognitive regulation in obsessive-compulsive patients using the PubMed database. Most of the studies included explored behavioral (distress, arousal, and frequency of intrusive thoughts) and neurobiological measures (brain activity and functional connectivity) using affective cognitive regulation paradigms. Our results pointed to the advantageous use of reappraisal and acceptance strategies in contrast to suppression to reduce distress and frequency of intrusive thoughts. Moreover, we observed alterations in frontoparietal network activity during cognitive regulation. Our conclusions are limited by the inclusion of underpowered studies with treated patients. Nonetheless, our findings support the OCD impairments in cognitive regulation of emotion and might help to improve current guidelines for cognitive therapy.
publishDate 2020
dc.date.none.fl_str_mv 2020-10
2020-10-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/68715
url http://hdl.handle.net/1822/68715
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ferreira, S.; Pêgo, J.M.; Morgado, P. A Systematic Review of Behavioral, Physiological, and Neurobiological Cognitive Regulation Alterations in Obsessive-Compulsive Disorder. Brain Sci. 2020, 10, 797. DOI: 10.3390/brainsci10110797
2076-3425
10.3390/brainsci10110797
https://www.mdpi.com/2076-3425/10/11/797
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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