The (Poly)phenol-Carbohydrate Combination for Diabetes

Detalhes bibliográficos
Autor(a) principal: de Matos, Ana Marta
Data de Publicação: 2023
Outros Autores: Menezes, Regina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/150626
Resumo: Funding: Centro de Química Estrutural is a Research Unit funded by Fundação para a Ciência e Tecnologia through projects UIDB/00100/2020 and UIDP/00100/2020. Institute of Molecular Sciences is an Associate Laboratory funded by FCT through project LA/P/0056/2020. A.M. Matos thanks FCT, CQE, and Faculdade de Ciências da Universidade de Lisboa for her CEECInst Junior Researcher Contract, and FCT for funding through the Individual Call for Scientific Employment Stimulus (2022.07037.CEECIND). CBIOS—Universidade Lusófona’s Research Center for Biosciences & Health Technologies is a Research Unit funded by Fundação para a Ciência e Tecnologia through projects grants UIDB/04567/2020 and UIDP/04567/2020 to CBIOS. R.M. also thanks FCT and CBIOS for her CEECInst Assistant Researcher Contract (CEEC/04567/CBIOS/2020) and COFAC/ILIND—Cooperativa De Formação e Animação Cultural CRL/Instituto Lusófono de Investigação e Desenvolvimento (grant COFAC/ILIND/CBIOS/2/2021).
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spelling The (Poly)phenol-Carbohydrate Combination for DiabetesWhere Do We Stand?Pan-Assay Interference Compoundsinvalid metabolic panaceasfunctional nutrientsnatural product-based drug discoveryC-glucosylationSDG 3 - Good Health and Well-beingFunding: Centro de Química Estrutural is a Research Unit funded by Fundação para a Ciência e Tecnologia through projects UIDB/00100/2020 and UIDP/00100/2020. Institute of Molecular Sciences is an Associate Laboratory funded by FCT through project LA/P/0056/2020. A.M. Matos thanks FCT, CQE, and Faculdade de Ciências da Universidade de Lisboa for her CEECInst Junior Researcher Contract, and FCT for funding through the Individual Call for Scientific Employment Stimulus (2022.07037.CEECIND). CBIOS—Universidade Lusófona’s Research Center for Biosciences & Health Technologies is a Research Unit funded by Fundação para a Ciência e Tecnologia through projects grants UIDB/04567/2020 and UIDP/04567/2020 to CBIOS. R.M. also thanks FCT and CBIOS for her CEECInst Assistant Researcher Contract (CEEC/04567/CBIOS/2020) and COFAC/ILIND—Cooperativa De Formação e Animação Cultural CRL/Instituto Lusófono de Investigação e Desenvolvimento (grant COFAC/ILIND/CBIOS/2/2021).The type 2 diabetes epidemic is real and hardly coming to an end in the upcoming years. The efforts of the scientific community to develop safer and more effective compounds for type 2 diabetes based on the structure of natural (poly)phenols are remarkable and have indeed proven worthwhile after the introduction of gliflozins in clinical practice. However, low-quality reports on the antidiabetic potential of plant-derived lipophilic (poly)phenols continue to pile up in the literature. Many of these compounds continue to be published as promising functional nutrients and antidiabetic pharmaceutical leads without consideration of their Pan-Assay Interference Compounds (PAINS) profile. This evidence-based opinion article conveys the authors' perspectives on the natural (poly)phenol artillery as a valuable and reliable source of bioactive compounds for diabetes. Ultimately, in light of the already established membrane-perturbing behavior of lipophilic (poly)phenols, together with the multiple benefits that may come with the introduction of a C-glucosyl moiety in bioactive compounds, we aim to raise awareness of the importance of contemplating the shift to (poly)phenol-carbohydrate combinations in the development of functional nutrients, as well as in the early stages of antidiabetic drug discovery.iNOVA4Health - pólo NMSNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNde Matos, Ana MartaMenezes, Regina2023-03-15T22:29:20Z2023-02-162023-02-16T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/150626eng1422-8599PURE: 54518446https://doi.org/10.3390/nu15040996info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:32:40Zoai:run.unl.pt:10362/150626Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:54:13.009419Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The (Poly)phenol-Carbohydrate Combination for Diabetes
Where Do We Stand?
title The (Poly)phenol-Carbohydrate Combination for Diabetes
spellingShingle The (Poly)phenol-Carbohydrate Combination for Diabetes
de Matos, Ana Marta
Pan-Assay Interference Compounds
invalid metabolic panaceas
functional nutrients
natural product-based drug discovery
C-glucosylation
SDG 3 - Good Health and Well-being
title_short The (Poly)phenol-Carbohydrate Combination for Diabetes
title_full The (Poly)phenol-Carbohydrate Combination for Diabetes
title_fullStr The (Poly)phenol-Carbohydrate Combination for Diabetes
title_full_unstemmed The (Poly)phenol-Carbohydrate Combination for Diabetes
title_sort The (Poly)phenol-Carbohydrate Combination for Diabetes
author de Matos, Ana Marta
author_facet de Matos, Ana Marta
Menezes, Regina
author_role author
author2 Menezes, Regina
author2_role author
dc.contributor.none.fl_str_mv iNOVA4Health - pólo NMS
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv de Matos, Ana Marta
Menezes, Regina
dc.subject.por.fl_str_mv Pan-Assay Interference Compounds
invalid metabolic panaceas
functional nutrients
natural product-based drug discovery
C-glucosylation
SDG 3 - Good Health and Well-being
topic Pan-Assay Interference Compounds
invalid metabolic panaceas
functional nutrients
natural product-based drug discovery
C-glucosylation
SDG 3 - Good Health and Well-being
description Funding: Centro de Química Estrutural is a Research Unit funded by Fundação para a Ciência e Tecnologia through projects UIDB/00100/2020 and UIDP/00100/2020. Institute of Molecular Sciences is an Associate Laboratory funded by FCT through project LA/P/0056/2020. A.M. Matos thanks FCT, CQE, and Faculdade de Ciências da Universidade de Lisboa for her CEECInst Junior Researcher Contract, and FCT for funding through the Individual Call for Scientific Employment Stimulus (2022.07037.CEECIND). CBIOS—Universidade Lusófona’s Research Center for Biosciences & Health Technologies is a Research Unit funded by Fundação para a Ciência e Tecnologia through projects grants UIDB/04567/2020 and UIDP/04567/2020 to CBIOS. R.M. also thanks FCT and CBIOS for her CEECInst Assistant Researcher Contract (CEEC/04567/CBIOS/2020) and COFAC/ILIND—Cooperativa De Formação e Animação Cultural CRL/Instituto Lusófono de Investigação e Desenvolvimento (grant COFAC/ILIND/CBIOS/2/2021).
publishDate 2023
dc.date.none.fl_str_mv 2023-03-15T22:29:20Z
2023-02-16
2023-02-16T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/150626
url http://hdl.handle.net/10362/150626
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1422-8599
PURE: 54518446
https://doi.org/10.3390/nu15040996
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eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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