Circulating (Poly)phenol Metabolites
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/131480 |
Resumo: | Funding Information: This work was supported by European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program under grant agreement No. 804229; iNOVA4Health – UIDB/04462/2020 and UIDP/04462/2020, a program financially supported by Fundação para a Ciência e Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES), through national funds. FCT/MCTES, through the project PTDC/BTM‐ORG/29580/2017. Authors would like to acknowledge FCT for financial support of R.C. (PD/BD/135492/2018) and J.G.‐P. (SFRH/BD/145522/2019). M.L. was supported by the Land‐BW (NAM‐ACCEPT) and funding by the European Union's Horizon 2020 research and innovation program under grant agreements No. 964537 (RISK‐HUNT3R), No. 964518 (ToxFree), and No. 825759 (ENDpoiNTs). Publisher Copyright: © 2022 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH |
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Circulating (Poly)phenol MetabolitesNeuroprotection in a 3D Cell Model of Parkinson's DiseaseBiotechnologyFood ScienceSDG 3 - Good Health and Well-beingFunding Information: This work was supported by European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program under grant agreement No. 804229; iNOVA4Health – UIDB/04462/2020 and UIDP/04462/2020, a program financially supported by Fundação para a Ciência e Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES), through national funds. FCT/MCTES, through the project PTDC/BTM‐ORG/29580/2017. Authors would like to acknowledge FCT for financial support of R.C. (PD/BD/135492/2018) and J.G.‐P. (SFRH/BD/145522/2019). M.L. was supported by the Land‐BW (NAM‐ACCEPT) and funding by the European Union's Horizon 2020 research and innovation program under grant agreements No. 964537 (RISK‐HUNT3R), No. 964518 (ToxFree), and No. 825759 (ENDpoiNTs). Publisher Copyright: © 2022 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbHScope: Diets rich in (poly)phenols have been associated with positive effects on neurodegenerative disorders, such as Parkinson's disease (PD). Several low-molecular weight (poly)phenol metabolites (LMWPM) are found in the plasma after consumption of (poly)phenol-rich food. It is expected that LMWPM, upon reaching the brain, may have beneficial effects against both oxidative stress and neuroinflammation, and possibly attenuate cell death mechanisms relate to the loss of dopaminergic neurons in PD. Methods and Results: This study investigates the neuroprotective potential of two blood-brain barrier permeant LMWPM, catechol-O-sulfate (cat-sulf), and pyrogallol-O-sulfate (pyr-sulf), in a human 3D cell model of PD. Neurospheroids were generated from LUHMES neuronal precursor cells and challenged by 1-methyl-4-phenylpyridinium (MPP+) to induce neuronal stress. LMWPM pretreatments were differently neuroprotective towards MPP+ insult, presenting distinct effects on the neuronal transcriptome. Particularly, cat-sulf pretreatment appeared to boost counter-regulatory defense mechanisms (preconditioning). When MPP+ is applied, both LMWPM positively modulated glutathione metabolism and heat-shock response, as also favorably shifting the balance of pro/anti-apoptotic proteins. Conclusions: Our findings point to the potential of LMWPM to trigger molecular mechanisms that help dopaminergic neurons to cope with a subsequent toxic insult. They are promising molecules to be further explored in the context of preventing and attenuating parkinsonian neurodegeneration.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Instituto de Tecnologia Química e Biológica António Xavier (ITQB)Centro de Estudos de Doenças Crónicas (CEDOC)RUNCarecho, RafaelFigueira, InêsTerrasso, Ana PaulaGodinho-Pereira, Joanade Oliveira Sequeira, CatarinaPereira, Sofia AzeredoMilenkovic, DraganLeist, MarcelBrito, CatarinaNunes dos Santos, Cláudia2022-01-25T03:30:23Z2022-01-082022-01-08T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/131480eng1613-4125PURE: 36283854https://doi.org/10.1002/mnfr.202100959info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:10:03Zoai:run.unl.pt:10362/131480Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:47:04.855617Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Circulating (Poly)phenol Metabolites Neuroprotection in a 3D Cell Model of Parkinson's Disease |
| title |
Circulating (Poly)phenol Metabolites |
| spellingShingle |
Circulating (Poly)phenol Metabolites Carecho, Rafael Biotechnology Food Science SDG 3 - Good Health and Well-being |
| title_short |
Circulating (Poly)phenol Metabolites |
| title_full |
Circulating (Poly)phenol Metabolites |
| title_fullStr |
Circulating (Poly)phenol Metabolites |
| title_full_unstemmed |
Circulating (Poly)phenol Metabolites |
| title_sort |
Circulating (Poly)phenol Metabolites |
| author |
Carecho, Rafael |
| author_facet |
Carecho, Rafael Figueira, Inês Terrasso, Ana Paula Godinho-Pereira, Joana de Oliveira Sequeira, Catarina Pereira, Sofia Azeredo Milenkovic, Dragan Leist, Marcel Brito, Catarina Nunes dos Santos, Cláudia |
| author_role |
author |
| author2 |
Figueira, Inês Terrasso, Ana Paula Godinho-Pereira, Joana de Oliveira Sequeira, Catarina Pereira, Sofia Azeredo Milenkovic, Dragan Leist, Marcel Brito, Catarina Nunes dos Santos, Cláudia |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Instituto de Tecnologia Química e Biológica António Xavier (ITQB) Centro de Estudos de Doenças Crónicas (CEDOC) RUN |
| dc.contributor.author.fl_str_mv |
Carecho, Rafael Figueira, Inês Terrasso, Ana Paula Godinho-Pereira, Joana de Oliveira Sequeira, Catarina Pereira, Sofia Azeredo Milenkovic, Dragan Leist, Marcel Brito, Catarina Nunes dos Santos, Cláudia |
| dc.subject.por.fl_str_mv |
Biotechnology Food Science SDG 3 - Good Health and Well-being |
| topic |
Biotechnology Food Science SDG 3 - Good Health and Well-being |
| description |
Funding Information: This work was supported by European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program under grant agreement No. 804229; iNOVA4Health – UIDB/04462/2020 and UIDP/04462/2020, a program financially supported by Fundação para a Ciência e Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES), through national funds. FCT/MCTES, through the project PTDC/BTM‐ORG/29580/2017. Authors would like to acknowledge FCT for financial support of R.C. (PD/BD/135492/2018) and J.G.‐P. (SFRH/BD/145522/2019). M.L. was supported by the Land‐BW (NAM‐ACCEPT) and funding by the European Union's Horizon 2020 research and innovation program under grant agreements No. 964537 (RISK‐HUNT3R), No. 964518 (ToxFree), and No. 825759 (ENDpoiNTs). Publisher Copyright: © 2022 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-01-25T03:30:23Z 2022-01-08 2022-01-08T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/131480 |
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http://hdl.handle.net/10362/131480 |
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eng |
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eng |
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1613-4125 PURE: 36283854 https://doi.org/10.1002/mnfr.202100959 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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